Altered Lipid Profiles and Vaccine Induced-Humoral Responses in Children Living With HIV on Antiretroviral Therapy in Tanzania Article Swipe
Wilbert Mbuya
,
Issakwisa Habakkuk Mwakyula
,
Willyelimina Olomi
,
Peter Agrea
,
Francesco Nicoli
,
Cecilia Ngatunga
,
Leodegard Mujwahuzi
,
Paul J. Mwanyika
,
Mkunde Chachage
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fcimb.2021.721747
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fcimb.2021.721747
People living with HIV, even under therapy, have a high burden of age-related co-morbidities including an increased risk of dyslipidemia (which often predisposes to cardiovascular diseases) and immune-aging. In this study, lipid profiles and antibody responses to measles and pertussis toxin vaccines were compared between ART experienced HIV+ children (n=64) aged 5-10 years, and their age- and sex-matched HIV- controls (n=47). Prevalence of high-density lipoprotein cholesterol (HDL-c) and triglyceride-driven dyslipidemia was higher among treated HIV+ children than in controls (51.6% vs 27.7% respectively, p < 0.019). In a multivariate Poisson regression model adjusted for age, sex and BMI, the association between low HDL-c, hypertriglyceridemia and HIV remained significantly high (for HDL-c: ARR: 0.89, 95% CI: 0.82 – 0.96, p = 0.003; for triglycerides: ARR: 1.54, 95% CI: 1.31 – 1.81, p < 0.001). Among HIV+ children, the use of lopinavir/ritonavir, a protease-based antiretroviral therapy was also associated elevation of triglyceride levels (p = 0.032). Also, HIV+ children had a 2.8-fold reduction of anti-measles IgG titers and 17.1-fold reduction of anti-pertussis toxin IgG levels when compared to HIV- children. Our findings suggest that dyslipidemia and inadequate vaccine-induced antibody responses observed in this population of young African HIV+ children might increase their risk for premature onset of cardiovascular illnesses and acquisition of preventable diseases.
Related Topics
Concepts
Medicine
Dyslipidemia
Immunology
Ritonavir
Lopinavir
Internal medicine
Measles
Population
Hypertriglyceridemia
Vaccination
Cholesterol
Triglyceride
Viral load
Antiretroviral therapy
Human immunodeficiency virus (HIV)
Disease
Environmental health
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fcimb.2021.721747
- OA Status
- gold
- Cited By
- 2
- References
- 54
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3213362073
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3213362073Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fcimb.2021.721747Digital Object Identifier
- Title
-
Altered Lipid Profiles and Vaccine Induced-Humoral Responses in Children Living With HIV on Antiretroviral Therapy in TanzaniaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-11-09Full publication date if available
- Authors
-
Wilbert Mbuya, Issakwisa Habakkuk Mwakyula, Willyelimina Olomi, Peter Agrea, Francesco Nicoli, Cecilia Ngatunga, Leodegard Mujwahuzi, Paul J. Mwanyika, Mkunde ChachageList of authors in order
- Landing page
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https://doi.org/10.3389/fcimb.2021.721747Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3389/fcimb.2021.721747Direct OA link when available
- Concepts
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Medicine, Dyslipidemia, Immunology, Ritonavir, Lopinavir, Internal medicine, Measles, Population, Hypertriglyceridemia, Vaccination, Cholesterol, Triglyceride, Viral load, Antiretroviral therapy, Human immunodeficiency virus (HIV), Disease, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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54Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.age- | 55 |
| abstract_inverted_index.aged | 50 |
| abstract_inverted_index.also | 145 |
| abstract_inverted_index.even | 4 |
| abstract_inverted_index.have | 7 |
| abstract_inverted_index.high | 9, 108 |
| abstract_inverted_index.risk | 17, 200 |
| abstract_inverted_index.than | 76 |
| abstract_inverted_index.that | 181 |
| abstract_inverted_index.this | 29, 190 |
| abstract_inverted_index.were | 42 |
| abstract_inverted_index.when | 173 |
| abstract_inverted_index.with | 2 |
| abstract_inverted_index.0.89, | 112 |
| abstract_inverted_index.0.96, | 117 |
| abstract_inverted_index.1.54, | 124 |
| abstract_inverted_index.1.81, | 129 |
| abstract_inverted_index.27.7% | 81 |
| abstract_inverted_index.Also, | 154 |
| abstract_inverted_index.Among | 133 |
| abstract_inverted_index.among | 72 |
| abstract_inverted_index.lipid | 31 |
| abstract_inverted_index.might | 197 |
| abstract_inverted_index.model | 91 |
| abstract_inverted_index.often | 21 |
| abstract_inverted_index.onset | 203 |
| abstract_inverted_index.their | 54, 199 |
| abstract_inverted_index.toxin | 40, 170 |
| abstract_inverted_index.under | 5 |
| abstract_inverted_index.young | 193 |
| abstract_inverted_index.(51.6% | 79 |
| abstract_inverted_index.(n=64) | 49 |
| abstract_inverted_index.(which | 20 |
| abstract_inverted_index.0.003; | 120 |
| abstract_inverted_index.HDL-c, | 102 |
| abstract_inverted_index.HDL-c: | 110 |
| abstract_inverted_index.People | 0 |
| abstract_inverted_index.burden | 10 |
| abstract_inverted_index.higher | 71 |
| abstract_inverted_index.levels | 150, 172 |
| abstract_inverted_index.living | 1 |
| abstract_inverted_index.study, | 30 |
| abstract_inverted_index.titers | 164 |
| abstract_inverted_index.years, | 52 |
| abstract_inverted_index.(HDL-c) | 66 |
| abstract_inverted_index.(n=47). | 60 |
| abstract_inverted_index.0.001). | 132 |
| abstract_inverted_index.0.019). | 85 |
| abstract_inverted_index.0.032). | 153 |
| abstract_inverted_index.African | 194 |
| abstract_inverted_index.Poisson | 89 |
| abstract_inverted_index.between | 44, 100 |
| abstract_inverted_index.measles | 37 |
| abstract_inverted_index.suggest | 180 |
| abstract_inverted_index.therapy | 143 |
| abstract_inverted_index.treated | 73 |
| abstract_inverted_index.&lt; | 84, 131 |
| abstract_inverted_index.2.8-fold | 159 |
| abstract_inverted_index.adjusted | 92 |
| abstract_inverted_index.antibody | 34, 186 |
| abstract_inverted_index.children | 48, 75, 156, 196 |
| abstract_inverted_index.compared | 43, 174 |
| abstract_inverted_index.controls | 59, 78 |
| abstract_inverted_index.findings | 179 |
| abstract_inverted_index.increase | 198 |
| abstract_inverted_index.observed | 188 |
| abstract_inverted_index.profiles | 32 |
| abstract_inverted_index.remained | 106 |
| abstract_inverted_index.therapy, | 6 |
| abstract_inverted_index.vaccines | 41 |
| abstract_inverted_index.17.1-fold | 166 |
| abstract_inverted_index.children, | 135 |
| abstract_inverted_index.children. | 177 |
| abstract_inverted_index.diseases) | 25 |
| abstract_inverted_index.diseases. | 211 |
| abstract_inverted_index.elevation | 147 |
| abstract_inverted_index.illnesses | 206 |
| abstract_inverted_index.including | 14 |
| abstract_inverted_index.increased | 16 |
| abstract_inverted_index.pertussis | 39 |
| abstract_inverted_index.premature | 202 |
| abstract_inverted_index.reduction | 160, 167 |
| abstract_inverted_index.responses | 35, 187 |
| abstract_inverted_index.Prevalence | 61 |
| abstract_inverted_index.associated | 146 |
| abstract_inverted_index.inadequate | 184 |
| abstract_inverted_index.population | 191 |
| abstract_inverted_index.regression | 90 |
| abstract_inverted_index.acquisition | 208 |
| abstract_inverted_index.age-related | 12 |
| abstract_inverted_index.association | 99 |
| abstract_inverted_index.cholesterol | 65 |
| abstract_inverted_index.experienced | 46 |
| abstract_inverted_index.lipoprotein | 64 |
| abstract_inverted_index.predisposes | 22 |
| abstract_inverted_index.preventable | 210 |
| abstract_inverted_index.sex-matched | 57 |
| abstract_inverted_index.anti-measles | 162 |
| abstract_inverted_index.dyslipidemia | 19, 69, 182 |
| abstract_inverted_index.high-density | 63 |
| abstract_inverted_index.multivariate | 88 |
| abstract_inverted_index.triglyceride | 149 |
| abstract_inverted_index.immune-aging. | 27 |
| abstract_inverted_index.respectively, | 82 |
| abstract_inverted_index.significantly | 107 |
| abstract_inverted_index.anti-pertussis | 169 |
| abstract_inverted_index.antiretroviral | 142 |
| abstract_inverted_index.cardiovascular | 24, 205 |
| abstract_inverted_index.co-morbidities | 13 |
| abstract_inverted_index.protease-based | 141 |
| abstract_inverted_index.triglycerides: | 122 |
| abstract_inverted_index.vaccine-induced | 185 |
| abstract_inverted_index.triglyceride-driven | 68 |
| abstract_inverted_index.hypertriglyceridemia | 103 |
| abstract_inverted_index.lopinavir/ritonavir, | 139 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5000953405, https://openalex.org/A5007911180 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I182078086, https://openalex.org/I3129830433, https://openalex.org/I4210164902 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8399999737739563 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.60178447 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |