Altered mRNA transport and local translation in iNeurons with RNA binding protein knockdown Article Swipe

View

Rachael Dargan , Alla Mikheenko , Nicholas L. Johnson , Benjamin Packer , Ziyi Li , Emma J. Craig , Stephanie L. Sarbanes , Colleen Bereda , Puja R. Mehta , Matthew J. Keuss , Mike A. Nalls , Yue Qi , Cory A. Weller , Pietro Fratta , Veronica H. Ryan ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.1101/2024.09.26.615153

Neurons rely on mRNA transport and local translation to facilitate rapid protein synthesis in processes far from the cell body. These processes allow precise spatial and temporal control of translation and are mediated by RNA binding proteins (RBPs), including those known to be associated with neurodegenerative diseases. Here, we use proteomics, transcriptomics, and microscopy to investigate the impact of RBP knockdown on mRNA transport and local translation in iPSC-derived neurons. We find thousands of transcripts enriched in neurites and that many of these transcripts are locally translated, possibly due to the shorter length of transcripts in neurites. Loss of frontotemporal dementia/amyotrophic lateral sclerosis (FTD/ALS)-associated RBPs TDP- 43 and hnRNPA1 lead to distinct alterations in the neuritic proteome and transcriptome. TDP-43 knockdown (KD) leads to increased neuritic mRNA and translation. In contrast, hnRNPA1 leads to increased neuritic mRNA, but not translation, and more moderate effects on local mRNA profiles, possibly due to compensation by hnRNPA3. These results highlight the crucial role of FTD/ALS-associated RBPs in mRNA transport and local translation in neurons and the importance of these processes in neuron health and disease.

Related Topics

Concepts

Gene knockdown Messenger RNA Translation (biology) RNA-binding protein Cell biology RNA Chemistry Molecular biology Biology Biochemistry Gene

Metadata

Type: preprint
Language: en
Landing Page: https://doi.org/10.1101/2024.09.26.615153
OA Status: green
Cited By: 3
References: 64
Related Works: 10
OpenAlex ID: https://openalex.org/W4402908119

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4402908119

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1101/2024.09.26.615153

Digital Object Identifier
Title: Altered mRNA transport and local translation in iNeurons with RNA binding protein knockdown

Work title
Type: preprint

OpenAlex work type
Language: en

Primary language
Publication year: 2024

Year of publication
Publication date: 2024-09-27

Full publication date if available
Authors: Rachael Dargan, Alla Mikheenko, Nicholas L. Johnson, Benjamin Packer, Ziyi Li, Emma J. Craig, Stephanie L. Sarbanes, Colleen Bereda, Puja R. Mehta, Matthew J. Keuss, Mike A. Nalls, Yue Qi, Cory A. Weller, Pietro Fratta, Veronica H. Ryan

List of authors in order
Landing page: https://doi.org/10.1101/2024.09.26.615153

Publisher landing page
Open access: Yes

Whether a free full text is available
OA status: green

Open access status per OpenAlex
OA URL: https://doi.org/10.1101/2024.09.26.615153

Direct OA link when available
Concepts: Gene knockdown, Messenger RNA, Translation (biology), RNA-binding protein, Cell biology, RNA, Chemistry, Molecular biology, Biology, Biochemistry, Gene

Top concepts (fields/topics) attached by OpenAlex
Cited by: 3

Total citation count in OpenAlex
Citations by year (recent): 2025: 3

Per-year citation counts (last 5 years)
References (count): 64

Number of works referenced by this work
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W4402908119
doi	https://doi.org/10.1101/2024.09.26.615153
ids.doi	https://doi.org/10.1101/2024.09.26.615153
ids.pmid	https://pubmed.ncbi.nlm.nih.gov/39386562
ids.openalex	https://openalex.org/W4402908119
fwci	1.44074168
type	preprint
title	Altered mRNA transport and local translation in iNeurons with RNA binding protein knockdown
biblio.issue
biblio.volume
biblio.last_page
biblio.first_page
topics[0].id	https://openalex.org/T10604
topics[0].field.id	https://openalex.org/fields/13
topics[0].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[0].score	0.9998999834060669
topics[0].domain.id	https://openalex.org/domains/1
topics[0].domain.display_name	Life Sciences
topics[0].subfield.id	https://openalex.org/subfields/1312
topics[0].subfield.display_name	Molecular Biology
topics[0].display_name	RNA Research and Splicing
topics[1].id	https://openalex.org/T11482
topics[1].field.id	https://openalex.org/fields/13
topics[1].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[1].score	0.9987000226974487
topics[1].domain.id	https://openalex.org/domains/1
topics[1].domain.display_name	Life Sciences
topics[1].subfield.id	https://openalex.org/subfields/1312
topics[1].subfield.display_name	Molecular Biology
topics[1].display_name	RNA modifications and cancer
topics[2].id	https://openalex.org/T10521
topics[2].field.id	https://openalex.org/fields/13
topics[2].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[2].score	0.998199999332428
topics[2].domain.id	https://openalex.org/domains/1
topics[2].domain.display_name	Life Sciences
topics[2].subfield.id	https://openalex.org/subfields/1312
topics[2].subfield.display_name	Molecular Biology
topics[2].display_name	RNA and protein synthesis mechanisms
is_xpac	False
apc_list
apc_paid
concepts[0].id	https://openalex.org/C173396325
concepts[0].level	3
concepts[0].score	0.8545211553573608
concepts[0].wikidata	https://www.wikidata.org/wiki/Q1501275
concepts[0].display_name	Gene knockdown
concepts[1].id	https://openalex.org/C105580179
concepts[1].level	3
concepts[1].score	0.7211646437644958
concepts[1].wikidata	https://www.wikidata.org/wiki/Q188928
concepts[1].display_name	Messenger RNA
concepts[2].id	https://openalex.org/C149364088
concepts[2].level	4
concepts[2].score	0.6755867600440979
concepts[2].wikidata	https://www.wikidata.org/wiki/Q185917
concepts[2].display_name	Translation (biology)
concepts[3].id	https://openalex.org/C41282012
concepts[3].level	4
concepts[3].score	0.5696557760238647
concepts[3].wikidata	https://www.wikidata.org/wiki/Q3928341
concepts[3].display_name	RNA-binding protein
concepts[4].id	https://openalex.org/C95444343
concepts[4].level	1
concepts[4].score	0.4764944911003113
concepts[4].wikidata	https://www.wikidata.org/wiki/Q7141
concepts[4].display_name	Cell biology
concepts[5].id	https://openalex.org/C67705224
concepts[5].level	3
concepts[5].score	0.4598373770713806
concepts[5].wikidata	https://www.wikidata.org/wiki/Q11053
concepts[5].display_name	RNA
concepts[6].id	https://openalex.org/C185592680
concepts[6].level	0
concepts[6].score	0.44405949115753174
concepts[6].wikidata	https://www.wikidata.org/wiki/Q2329
concepts[6].display_name	Chemistry
concepts[7].id	https://openalex.org/C153911025
concepts[7].level	1
concepts[7].score	0.3699154853820801
concepts[7].wikidata	https://www.wikidata.org/wiki/Q7202
concepts[7].display_name	Molecular biology
concepts[8].id	https://openalex.org/C86803240
concepts[8].level	0
concepts[8].score	0.25590455532073975
concepts[8].wikidata	https://www.wikidata.org/wiki/Q420
concepts[8].display_name	Biology
concepts[9].id	https://openalex.org/C55493867
concepts[9].level	1
concepts[9].score	0.16494843363761902
concepts[9].wikidata	https://www.wikidata.org/wiki/Q7094
concepts[9].display_name	Biochemistry
concepts[10].id	https://openalex.org/C104317684
concepts[10].level	2
concepts[10].score	0.133622944355011
concepts[10].wikidata	https://www.wikidata.org/wiki/Q7187
concepts[10].display_name	Gene
keywords[0].id	https://openalex.org/keywords/gene-knockdown
keywords[0].score	0.8545211553573608
keywords[0].display_name	Gene knockdown
keywords[1].id	https://openalex.org/keywords/messenger-rna
keywords[1].score	0.7211646437644958
keywords[1].display_name	Messenger RNA
keywords[2].id	https://openalex.org/keywords/translation
keywords[2].score	0.6755867600440979
keywords[2].display_name	Translation (biology)
keywords[3].id	https://openalex.org/keywords/rna-binding-protein
keywords[3].score	0.5696557760238647
keywords[3].display_name	RNA-binding protein
keywords[4].id	https://openalex.org/keywords/cell-biology
keywords[4].score	0.4764944911003113
keywords[4].display_name	Cell biology
keywords[5].id	https://openalex.org/keywords/rna
keywords[5].score	0.4598373770713806
keywords[5].display_name	RNA
keywords[6].id	https://openalex.org/keywords/chemistry
keywords[6].score	0.44405949115753174
keywords[6].display_name	Chemistry
keywords[7].id	https://openalex.org/keywords/molecular-biology
keywords[7].score	0.3699154853820801
keywords[7].display_name	Molecular biology
keywords[8].id	https://openalex.org/keywords/biology
keywords[8].score	0.25590455532073975
keywords[8].display_name	Biology
keywords[9].id	https://openalex.org/keywords/biochemistry
keywords[9].score	0.16494843363761902
keywords[9].display_name	Biochemistry
keywords[10].id	https://openalex.org/keywords/gene
keywords[10].score	0.133622944355011
keywords[10].display_name	Gene
language	en
locations[0].id	doi:10.1101/2024.09.26.615153
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S4306402567
locations[0].source.issn
locations[0].source.type	repository
locations[0].source.is_oa	False
locations[0].source.issn_l
locations[0].source.is_core	False
locations[0].source.is_in_doaj	False
locations[0].source.display_name	bioRxiv (Cold Spring Harbor Laboratory)
locations[0].source.host_organization	https://openalex.org/I2750212522
locations[0].source.host_organization_name	Cold Spring Harbor Laboratory
locations[0].source.host_organization_lineage	https://openalex.org/I2750212522
locations[0].license	public-domain
locations[0].pdf_url
locations[0].version	acceptedVersion
locations[0].raw_type	posted-content
locations[0].license_id	https://openalex.org/licenses/public-domain
locations[0].is_accepted	True
locations[0].is_published	False
locations[0].raw_source_name
locations[0].landing_page_url	https://doi.org/10.1101/2024.09.26.615153
locations[1].id	pmid:39386562
locations[1].is_oa	False
locations[1].source.id	https://openalex.org/S4306525036
locations[1].source.issn
locations[1].source.type	repository
locations[1].source.is_oa	False
locations[1].source.issn_l
locations[1].source.is_core	False
locations[1].source.is_in_doaj	False
locations[1].source.display_name	PubMed
locations[1].source.host_organization	https://openalex.org/I1299303238
locations[1].source.host_organization_name	National Institutes of Health
locations[1].source.host_organization_lineage	https://openalex.org/I1299303238
locations[1].license
locations[1].pdf_url
locations[1].version	publishedVersion
locations[1].raw_type
locations[1].license_id
locations[1].is_accepted	True
locations[1].is_published	True
locations[1].raw_source_name	bioRxiv : the preprint server for biology
locations[1].landing_page_url	https://pubmed.ncbi.nlm.nih.gov/39386562
locations[2].id	pmh:oai:pubmedcentral.nih.gov:11463369
locations[2].is_oa	True
locations[2].source.id	https://openalex.org/S2764455111
locations[2].source.issn
locations[2].source.type	repository
locations[2].source.is_oa	False
locations[2].source.issn_l
locations[2].source.is_core	False
locations[2].source.is_in_doaj	False
locations[2].source.display_name	PubMed Central
locations[2].source.host_organization	https://openalex.org/I1299303238
locations[2].source.host_organization_name	National Institutes of Health
locations[2].source.host_organization_lineage	https://openalex.org/I1299303238
locations[2].license	public-domain
locations[2].pdf_url
locations[2].version	submittedVersion
locations[2].raw_type	Text
locations[2].license_id	https://openalex.org/licenses/public-domain
locations[2].is_accepted	False
locations[2].is_published	False
locations[2].raw_source_name	bioRxiv
locations[2].landing_page_url	https://www.ncbi.nlm.nih.gov/pmc/articles/11463369
indexed_in	crossref, pubmed
authorships[0].author.id	https://openalex.org/A5107647865
authorships[0].author.orcid
authorships[0].author.display_name	Rachael Dargan
authorships[0].author_position	first
authorships[0].raw_author_name	Rachael Dargan
authorships[0].is_corresponding	False
authorships[1].author.id	https://openalex.org/A5066700628
authorships[1].author.orcid	https://orcid.org/0000-0003-3400-9719
authorships[1].author.display_name	Alla Mikheenko
authorships[1].author_position	middle
authorships[1].raw_author_name	Alla Mikheenko
authorships[1].is_corresponding	False
authorships[2].author.id	https://openalex.org/A5034881251
authorships[2].author.orcid	https://orcid.org/0009-0004-1464-5050
authorships[2].author.display_name	Nicholas L. Johnson
authorships[2].author_position	middle
authorships[2].raw_author_name	Nicholas L. Johnson
authorships[2].is_corresponding	False
authorships[3].author.id	https://openalex.org/A5114235184
authorships[3].author.orcid
authorships[3].author.display_name	Benjamin Packer
authorships[3].author_position	middle
authorships[3].raw_author_name	Benjamin Packer
authorships[3].is_corresponding	False
authorships[4].author.id	https://openalex.org/A5100389137
authorships[4].author.orcid	https://orcid.org/0000-0002-5165-8772
authorships[4].author.display_name	Ziyi Li
authorships[4].author_position	middle
authorships[4].raw_author_name	Ziyi Li
authorships[4].is_corresponding	False
authorships[5].author.id	https://openalex.org/A5113405014
authorships[5].author.orcid
authorships[5].author.display_name	Emma J. Craig
authorships[5].author_position	middle
authorships[5].raw_author_name	Emma J. Craig
authorships[5].is_corresponding	False
authorships[6].author.id	https://openalex.org/A5018253905
authorships[6].author.orcid	https://orcid.org/0000-0003-0051-8523
authorships[6].author.display_name	Stephanie L. Sarbanes
authorships[6].author_position	middle
authorships[6].raw_author_name	Stephanie L. Sarbanes
authorships[6].is_corresponding	False
authorships[7].author.id	https://openalex.org/A5031501920
authorships[7].author.orcid	https://orcid.org/0000-0002-9435-6141
authorships[7].author.display_name	Colleen Bereda
authorships[7].author_position	middle
authorships[7].raw_author_name	Colleen Bereda
authorships[7].is_corresponding	False
authorships[8].author.id	https://openalex.org/A5000564787
authorships[8].author.orcid	https://orcid.org/0000-0002-0255-407X
authorships[8].author.display_name	Puja R. Mehta
authorships[8].author_position	middle
authorships[8].raw_author_name	Puja R. Mehta
authorships[8].is_corresponding	False
authorships[9].author.id	https://openalex.org/A5070293807
authorships[9].author.orcid	https://orcid.org/0000-0002-2628-4115
authorships[9].author.display_name	Matthew J. Keuss
authorships[9].author_position	middle
authorships[9].raw_author_name	Matthew Keuss
authorships[9].is_corresponding	False
authorships[10].author.id	https://openalex.org/A5113839983
authorships[10].author.orcid
authorships[10].author.display_name	Mike A. Nalls
authorships[10].author_position	middle
authorships[10].raw_author_name	Mike A. Nalls
authorships[10].is_corresponding	False
authorships[11].author.id	https://openalex.org/A5039117237
authorships[11].author.orcid	https://orcid.org/0000-0003-1914-8710
authorships[11].author.display_name	Yue Qi
authorships[11].author_position	middle
authorships[11].raw_author_name	Yue A. Qi
authorships[11].is_corresponding	False
authorships[12].author.id	https://openalex.org/A5077123205
authorships[12].author.orcid	https://orcid.org/0000-0001-6965-5599
authorships[12].author.display_name	Cory A. Weller
authorships[12].author_position	middle
authorships[12].raw_author_name	Cory A. Weller
authorships[12].is_corresponding	False
authorships[13].author.id	https://openalex.org/A5057035079
authorships[13].author.orcid
authorships[13].author.display_name	Pietro Fratta
authorships[13].author_position	middle
authorships[13].raw_author_name	Pietro Fratta
authorships[13].is_corresponding	False
authorships[14].author.id	https://openalex.org/A5003043392
authorships[14].author.orcid	https://orcid.org/0000-0001-5121-4672
authorships[14].author.display_name	Veronica H. Ryan
authorships[14].author_position	last
authorships[14].raw_author_name	Veronica H. Ryan
authorships[14].is_corresponding	False
has_content.pdf	False
has_content.grobid_xml	False
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://doi.org/10.1101/2024.09.26.615153
open_access.oa_status	green
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	Altered mRNA transport and local translation in iNeurons with RNA binding protein knockdown
has_fulltext	False
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T10604
primary_topic.field.id	https://openalex.org/fields/13
primary_topic.field.display_name	Biochemistry, Genetics and Molecular Biology
primary_topic.score	0.9998999834060669
primary_topic.domain.id	https://openalex.org/domains/1
primary_topic.domain.display_name	Life Sciences
primary_topic.subfield.id	https://openalex.org/subfields/1312
primary_topic.subfield.display_name	Molecular Biology
primary_topic.display_name	RNA Research and Splicing
related_works	https://openalex.org/W4386799875, https://openalex.org/W4213065871, https://openalex.org/W4361818220, https://openalex.org/W4361818978, https://openalex.org/W4361818627, https://openalex.org/W3157667906, https://openalex.org/W2800322456, https://openalex.org/W2931234257, https://openalex.org/W4322719908, https://openalex.org/W3174925618
cited_by_count	3
counts_by_year[0].year	2025
counts_by_year[0].cited_by_count	3
locations_count	3
best_oa_location.id	doi:10.1101/2024.09.26.615153
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S4306402567
best_oa_location.source.issn
best_oa_location.source.type	repository
best_oa_location.source.is_oa	False
best_oa_location.source.issn_l
best_oa_location.source.is_core	False
best_oa_location.source.is_in_doaj	False
best_oa_location.source.display_name	bioRxiv (Cold Spring Harbor Laboratory)
best_oa_location.source.host_organization	https://openalex.org/I2750212522
best_oa_location.source.host_organization_name	Cold Spring Harbor Laboratory
best_oa_location.source.host_organization_lineage	https://openalex.org/I2750212522
best_oa_location.license	public-domain
best_oa_location.pdf_url
best_oa_location.version	acceptedVersion
best_oa_location.raw_type	posted-content
best_oa_location.license_id	https://openalex.org/licenses/public-domain
best_oa_location.is_accepted	True
best_oa_location.is_published	False
best_oa_location.raw_source_name
best_oa_location.landing_page_url	https://doi.org/10.1101/2024.09.26.615153
primary_location.id	doi:10.1101/2024.09.26.615153
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S4306402567
primary_location.source.issn
primary_location.source.type	repository
primary_location.source.is_oa	False
primary_location.source.issn_l
primary_location.source.is_core	False
primary_location.source.is_in_doaj	False
primary_location.source.display_name	bioRxiv (Cold Spring Harbor Laboratory)
primary_location.source.host_organization	https://openalex.org/I2750212522
primary_location.source.host_organization_name	Cold Spring Harbor Laboratory
primary_location.source.host_organization_lineage	https://openalex.org/I2750212522
primary_location.license	public-domain
primary_location.pdf_url
primary_location.version	acceptedVersion
primary_location.raw_type	posted-content
primary_location.license_id	https://openalex.org/licenses/public-domain
primary_location.is_accepted	True
primary_location.is_published	False
primary_location.raw_source_name
primary_location.landing_page_url	https://doi.org/10.1101/2024.09.26.615153
publication_date	2024-09-27
publication_year	2024
referenced_works	https://openalex.org/W4393315783, https://openalex.org/W4390669392, https://openalex.org/W4394579804, https://openalex.org/W4372332501, https://openalex.org/W2130410032, https://openalex.org/W4399123405, https://openalex.org/W3208691473, https://openalex.org/W2127753171, https://openalex.org/W2073073462, https://openalex.org/W2149000887, https://openalex.org/W2120728136, https://openalex.org/W2195925510, https://openalex.org/W2035618305, https://openalex.org/W3049616059, https://openalex.org/W2132166526, https://openalex.org/W2755967204, https://openalex.org/W2074393382, https://openalex.org/W2010457001, https://openalex.org/W2154923417, https://openalex.org/W4297627084, https://openalex.org/W4391258663, https://openalex.org/W3092338105, https://openalex.org/W1965286266, https://openalex.org/W2179438025, https://openalex.org/W2803819386, https://openalex.org/W2760524820, https://openalex.org/W2795614118, https://openalex.org/W2159713770, https://openalex.org/W3158711214, https://openalex.org/W3024189181, https://openalex.org/W2067132969, https://openalex.org/W3004751996, https://openalex.org/W2079226464, https://openalex.org/W4389704443, https://openalex.org/W4287577957, https://openalex.org/W2995312562, https://openalex.org/W2914447702, https://openalex.org/W2107554012, https://openalex.org/W2949324846, https://openalex.org/W2991106430, https://openalex.org/W1853546723, https://openalex.org/W2951257711, https://openalex.org/W4386865771, https://openalex.org/W2138207763, https://openalex.org/W2169456326, https://openalex.org/W2592811885, https://openalex.org/W2785329615, https://openalex.org/W3131055609, https://openalex.org/W4317797127, https://openalex.org/W2077610405, https://openalex.org/W3080570440, https://openalex.org/W4327681881, https://openalex.org/W3138498421, https://openalex.org/W2513030033, https://openalex.org/W4323048959, https://openalex.org/W3096676253, https://openalex.org/W53544134, https://openalex.org/W2967789674, https://openalex.org/W2103017472, https://openalex.org/W4388946825, https://openalex.org/W2102883851, https://openalex.org/W3131024606, https://openalex.org/W1969701330, https://openalex.org/W3159204943
referenced_works_count	64
abstract_inverted_index.43	107
abstract_inverted_index.In	130
abstract_inverted_index.We	71
abstract_inverted_index.be	43
abstract_inverted_index.by	34, 153
abstract_inverted_index.in	14, 68, 77, 96, 114, 164, 170, 178
abstract_inverted_index.of	29, 59, 74, 82, 94, 99, 161, 175
abstract_inverted_index.on	3, 62, 145
abstract_inverted_index.to	9, 42, 55, 90, 111, 124, 134, 151
abstract_inverted_index.we	49
abstract_inverted_index.RBP	60
abstract_inverted_index.RNA	35
abstract_inverted_index.and	6, 26, 31, 53, 65, 79, 108, 118, 128, 141, 167, 172, 181
abstract_inverted_index.are	32, 85
abstract_inverted_index.but	138
abstract_inverted_index.due	89, 150
abstract_inverted_index.far	16
abstract_inverted_index.not	139
abstract_inverted_index.the	18, 57, 91, 115, 158, 173
abstract_inverted_index.use	50
abstract_inverted_index.(KD)	122
abstract_inverted_index.Loss	98
abstract_inverted_index.RBPs	105, 163
abstract_inverted_index.TDP-	106
abstract_inverted_index.cell	19
abstract_inverted_index.find	72
abstract_inverted_index.from	17
abstract_inverted_index.lead	110
abstract_inverted_index.mRNA	4, 63, 127, 147, 165
abstract_inverted_index.many	81
abstract_inverted_index.more	142
abstract_inverted_index.rely	2
abstract_inverted_index.role	160
abstract_inverted_index.that	80
abstract_inverted_index.with	45
abstract_inverted_index.Here,	48
abstract_inverted_index.These	21, 155
abstract_inverted_index.allow	23
abstract_inverted_index.body.	20
abstract_inverted_index.known	41
abstract_inverted_index.leads	123, 133
abstract_inverted_index.local	7, 66, 146, 168
abstract_inverted_index.mRNA,	137
abstract_inverted_index.rapid	11
abstract_inverted_index.these	83, 176
abstract_inverted_index.those	40
abstract_inverted_index.TDP-43	120
abstract_inverted_index.health	180
abstract_inverted_index.impact	58
abstract_inverted_index.length	93
abstract_inverted_index.neuron	179
abstract_inverted_index.(RBPs),	38
abstract_inverted_index.Neurons	1
abstract_inverted_index.binding	36
abstract_inverted_index.control	28
abstract_inverted_index.crucial	159
abstract_inverted_index.effects	144
abstract_inverted_index.hnRNPA1	109, 132
abstract_inverted_index.lateral	102
abstract_inverted_index.locally	86
abstract_inverted_index.neurons	171
abstract_inverted_index.precise	24
abstract_inverted_index.protein	12
abstract_inverted_index.results	156
abstract_inverted_index.shorter	92
abstract_inverted_index.spatial	25
abstract_inverted_index.Abstract	0
abstract_inverted_index.disease.	182
abstract_inverted_index.distinct	112
abstract_inverted_index.enriched	76
abstract_inverted_index.hnRNPA3.	154
abstract_inverted_index.mediated	33
abstract_inverted_index.moderate	143
abstract_inverted_index.neurites	78
abstract_inverted_index.neuritic	116, 126, 136
abstract_inverted_index.neurons.	70
abstract_inverted_index.possibly	88, 149
abstract_inverted_index.proteins	37
abstract_inverted_index.proteome	117
abstract_inverted_index.temporal	27
abstract_inverted_index.contrast,	131
abstract_inverted_index.diseases.	47
abstract_inverted_index.highlight	157
abstract_inverted_index.including	39
abstract_inverted_index.increased	125, 135
abstract_inverted_index.knockdown	61, 121
abstract_inverted_index.neurites.	97
abstract_inverted_index.processes	15, 22, 177
abstract_inverted_index.profiles,	148
abstract_inverted_index.sclerosis	103
abstract_inverted_index.synthesis	13
abstract_inverted_index.thousands	73
abstract_inverted_index.transport	5, 64, 166
abstract_inverted_index.associated	44
abstract_inverted_index.facilitate	10
abstract_inverted_index.importance	174
abstract_inverted_index.microscopy	54
abstract_inverted_index.alterations	113
abstract_inverted_index.investigate	56
abstract_inverted_index.proteomics,	51
abstract_inverted_index.transcripts	75, 84, 95
abstract_inverted_index.translated,	87
abstract_inverted_index.translation	8, 30, 67, 169
abstract_inverted_index.compensation	152
abstract_inverted_index.iPSC-derived	69
abstract_inverted_index.translation,	140
abstract_inverted_index.translation.	129
abstract_inverted_index.frontotemporal	100
abstract_inverted_index.transcriptome.	119
abstract_inverted_index.transcriptomics,	52
abstract_inverted_index.neurodegenerative	46
abstract_inverted_index.FTD/ALS-associated	162
abstract_inverted_index.(FTD/ALS)-associated	104
abstract_inverted_index.dementia/amyotrophic	101
cited_by_percentile_year.max	97
cited_by_percentile_year.min	96
countries_distinct_count	0
institutions_distinct_count	15
citation_normalized_percentile.value	0.75814697
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False