Alzheimer Disease Associated Loci: APOE Single Nucleotide Polymorphisms in Marmara Region Article Swipe
Aya Badeea Ismail
,
Mehmet Sait Dündar
,
Cemre Ornek Erguzeloglu
,
Mahmut Çerkez Ergören
,
Adem Alemdar
,
Şebnem Özemri Sağ
,
Şehime Gülsün Temel
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/biomedicines12050968
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/biomedicines12050968
Alzheimer’s disease (AD) is a major global health challenge, especially among individuals aged 65 or older. According to population health studies, Turkey has the highest AD prevalence in the Middle East and Europe. To accurately determine the frequencies of common and rare APOE single nucleotide polymorphisms (SNPs) in the Turkish population residing in the Marmara Region, we conducted a retrospective study analyzing APOE variants in 588 individuals referred to the Bursa Uludag University Genetic Diseases Evaluation Center. Molecular genotyping, clinical exome sequencing, bioinformatics analysis, and statistical evaluation were employed to identify APOE polymorphisms and assess their distribution. The study revealed the frequencies of APOE alleles as follows: ε4 at 9.94%, ε2 at 9.18%, and ε3 at 80.68%. The gender-based analysis in our study uncovered a tendency for females to exhibit a higher prevalence of mutant genotypes across various SNPs. The most prevalent haplotype observed was ε3/ε3, while rare APOE SNPs were also identified. These findings align with global observations, underscoring the significance of genetic diversity and gender-specific characteristics in comprehending health disparities and formulating preventive strategies.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/biomedicines12050968
- https://www.mdpi.com/2227-9059/12/5/968/pdf?version=1714201512
- OA Status
- gold
- Cited By
- 1
- References
- 39
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4396592898
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- DOI
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https://doi.org/10.3390/biomedicines12050968Digital Object Identifier
- Title
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Alzheimer Disease Associated Loci: APOE Single Nucleotide Polymorphisms in Marmara RegionWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-04-27Full publication date if available
- Authors
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Aya Badeea Ismail, Mehmet Sait Dündar, Cemre Ornek Erguzeloglu, Mahmut Çerkez Ergören, Adem Alemdar, Şebnem Özemri Sağ, Şehime Gülsün TemelList of authors in order
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https://doi.org/10.3390/biomedicines12050968Publisher landing page
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https://www.mdpi.com/2227-9059/12/5/968/pdf?version=1714201512Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2227-9059/12/5/968/pdf?version=1714201512Direct OA link when available
- Concepts
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Apolipoprotein E, Single-nucleotide polymorphism, Genetics, Disease, Biology, Medicine, Genotype, Gene, PathologyTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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