Amelioration of cognitive impairment using epigallocatechin-3-gallate in ovariectomized mice fed a high-fat diet involves remodeling with Prevotella and Bifidobacteriales Article Swipe
Yang Qu
,
Yan Wu
,
Wei Cheng
,
Dongyang Wang
,
Lu Zeng
,
Yanru Wang
,
Tingting Li
,
Liye Zhang
,
Jinan Yang
,
Liyang Sun
,
Jing Ai
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fphar.2022.1079313
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fphar.2022.1079313
Background: Estrogen deficiency and a high-fat diet (HFD) are both risk factors for Alzheimer’s disease (AD). HFD can accelerate cognitive impairment in estrogen-deficient patients, but there is currently no effective treatment. Epigallocatechin-3-galate (EGCG) is widely studied for its anti-inflammatory, anti-cancer, and anti-neurodegeneration effects. Nevertheless, whether EGCG can ameliorate cognitive impairment in HFD-fed estrogen-deficient mice has not been studied. Methods and Results: Ovariectomized (OVX) mice fed an HFD (HFOVX) for 8 weeks experienced impaired object recognition and spatial memory, but this damage was significantly attenuated by the administration of EGCG at a dose of 45 mg/kg. Through 16S rRNA gene sequencing, we found that HFOVX changed the diversity and structure of the gut microbiota in mice, which could be restored with EGCG. Further analysis showed that HFOVX exposure not only resulted in a decrease of Alloprevotella in Bacteroidetes, Lactobacillaceae in Firmicutes, and Prevotella in Bacteroidetes but also in an increase of Bifidobacteriales in Actinobacteria. EGCG effectively reversed the decrease of Prevotella and inhibited the increase of Bifidobacteriales but had no effect on the decrease of Alloprevotella or Lactobacillaceae or on the increase of Enterorhabdus in HFOVX mice. Additionally, using Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, we found that EGCG significantly reversed the five functional gut microbiota genes elevated by HFOVX, including iron complex transport system substrate-binding protein, iron complex transport system permease protein, 3-oxoacyl- [acyl-carrier protein] reductase, transketolase, and 8-oxo-dGTP diphosphatase. Conclusions: We concluded that EGCG improved cognitive impairment in mice with estrogen deficiency exacerbated by an HFD involved a rebuilding of the disrupted gut microbiota composition.
Related Topics
Concepts
Prevotella
Ovariectomized rat
Estrogen
Endocrinology
Cognitive decline
KEGG
Gut flora
Internal medicine
Biology
Medicine
Biochemistry
Disease
Gene
Gene ontology
Genetics
Bacteria
Gene expression
Dementia
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fphar.2022.1079313
- https://www.frontiersin.org/articles/10.3389/fphar.2022.1079313/pdf
- OA Status
- gold
- Cited By
- 14
- References
- 65
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4313585844
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4313585844Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fphar.2022.1079313Digital Object Identifier
- Title
-
Amelioration of cognitive impairment using epigallocatechin-3-gallate in ovariectomized mice fed a high-fat diet involves remodeling with Prevotella and BifidobacterialesWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-01-04Full publication date if available
- Authors
-
Yang Qu, Yan Wu, Wei Cheng, Dongyang Wang, Lu Zeng, Yanru Wang, Tingting Li, Liye Zhang, Jinan Yang, Liyang Sun, Jing AiList of authors in order
- Landing page
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https://doi.org/10.3389/fphar.2022.1079313Publisher landing page
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https://www.frontiersin.org/articles/10.3389/fphar.2022.1079313/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fphar.2022.1079313/pdfDirect OA link when available
- Concepts
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Prevotella, Ovariectomized rat, Estrogen, Endocrinology, Cognitive decline, KEGG, Gut flora, Internal medicine, Biology, Medicine, Biochemistry, Disease, Gene, Gene ontology, Genetics, Bacteria, Gene expression, DementiaTop concepts (fields/topics) attached by OpenAlex
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14Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 5, 2023: 6Per-year citation counts (last 5 years)
- References (count)
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65Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.transketolase, | 229 |
| abstract_inverted_index.Actinobacteria. | 152 |
| abstract_inverted_index.Lactobacillaceae | 137, 176 |
| abstract_inverted_index.Bifidobacteriales | 150, 165 |
| abstract_inverted_index.substrate-binding | 217 |
| abstract_inverted_index.anti-inflammatory, | 38 |
| abstract_inverted_index.estrogen-deficient | 22, 52 |
| abstract_inverted_index.anti-neurodegeneration | 41 |
| abstract_inverted_index.Epigallocatechin-3-galate | 31 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 97 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 11 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7200000286102295 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.89355373 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |