Ameliorative Effect of Green synthesized Zinc Oxide Nanoparticles of Malvastrum coromandelianum Linn. on CCl 4 Induced Oxidative Stress in Sprague Dawley Rats Liver Article Swipe

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Sana Naseer , Abeel Naseer , Mehreen Fatima , Javed Iqbal , Sobia Kanwal , Banzeer Ahsan Abbasi , Mohsin Kazi , Mahboobeh Mahmoodi , Tariq Mahmood ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.21203/rs.3.rs-4442228/v1

Background: Malvastrum coromandelianum is an important medicinal plant enriched with active secondary metabolites. Leaves of plant have anti-inflammatory, antibacterial and hypoglycemic properties. Results: This study is based on hepato-protective properties of zinc-oxide nanoparticles synthesized using Malvastrum coromandelianum (MCZNPs) against inflammation and toxicity caused by CCl₄ in Sprague-Dawley rats. Nanoparticle’s formation was confirmed using UV visible spectroscopy by showing peak at 363nm. Shape (hexagonal) and size (23nm) was estimated using XRD and further confirmed by SEM (32.06 nm). MCZNPs possess antioxidant abilities, DPPH (44.3±0.6 µg/mL), superoxide scavenging activity (27.6±0.9 µg/mL), TAC (52.3±0.9 AAE mg/g) and TRP (47.5±0.9 GAE mg/g) values were comparable with standards. Initial treatment of female rats with MCZNPs revealed that MCZNPs were non-toxic. Anti-inflammatory potential was evaluated on forty two (1:1 male: female) rats divided into seven groups; I-control group (saline water-0.9%), II-treated with CCl₄ 1ml/kg bw, III-positive control group; CCl₄(1ml/kg bw)+silymarin (200mg/kg bw), IV and V-injected with 1ml/kg bw CCl₄and 150ml/kg bw and 300mg/kg bw of MCZNP, VI and VII-administered with 150ml/kg bw and 300mg/kg bw of MCZNP alone. Serum and antioxidant enzyme markers were found in normal range on co-administration of MCZNPs+CCl₄. MCZNPs significantly lowered CCl₄induced elevations in serum markers and restored antioxidant enzymes (SOD, POD, CAT, GSH) levels. However, gene expression analysis revealed that CCl₄ elevated oxidative stress and upregulated inflammatory markers (P<0.05). Whereas, MCZNPs suppressed oxidative stress markers. Hepatocyte morphology was examined by histopathological investigation. Conclusion: Nanoparticles synthesized using Malvastrum coromandelianum exhibited exceptional anti-inflammatory and antioxidant potential. Clinical trials of MCZNPs and investigation of underlying mechanisms would lead to the development of FDA approved drug.

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Oxidative stress Zinc Chemistry Nanoparticle Pharmacology Nuclear chemistry Traditional medicine Biochemistry Nanotechnology Materials science Medicine Organic chemistry

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Type: preprint
Language: en
Landing Page: https://doi.org/10.21203/rs.3.rs-4442228/v1
PDF: https://www.researchsquare.com/article/rs-4442228/latest.pdf
OA Status: gold
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DOI: https://doi.org/10.21203/rs.3.rs-4442228/v1

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Title: Ameliorative Effect of Green synthesized Zinc Oxide Nanoparticles of Malvastrum coromandelianum Linn. on CCl 4 Induced Oxidative Stress in Sprague Dawley Rats Liver

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Publication year: 2024

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Authors: Sana Naseer, Abeel Naseer, Mehreen Fatima, Javed Iqbal, Sobia Kanwal, Banzeer Ahsan Abbasi, Mohsin Kazi, Mahboobeh Mahmoodi, Tariq Mahmood

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Concepts: Oxidative stress, Zinc, Chemistry, Nanoparticle, Pharmacology, Nuclear chemistry, Traditional medicine, Biochemistry, Nanotechnology, Materials science, Medicine, Organic chemistry

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publication_date	2024-06-05
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referenced_works	https://openalex.org/W3009140821, https://openalex.org/W2511244056, https://openalex.org/W3030834164, https://openalex.org/W2070938379, https://openalex.org/W1735969114, https://openalex.org/W2768499679, https://openalex.org/W2953204393, https://openalex.org/W2791617524, https://openalex.org/W2236085244, https://openalex.org/W3198278986, https://openalex.org/W3004355005, https://openalex.org/W2171529323, https://openalex.org/W3028543080, https://openalex.org/W4206780758, https://openalex.org/W203960743, https://openalex.org/W2223403454, https://openalex.org/W1990244207, https://openalex.org/W3049317096, https://openalex.org/W3212878858, https://openalex.org/W2937188981, https://openalex.org/W2980958977, https://openalex.org/W3049457192, https://openalex.org/W3003173114, https://openalex.org/W2937630830, https://openalex.org/W2058759044, https://openalex.org/W2014803783, https://openalex.org/W2914523197, https://openalex.org/W3216366140, https://openalex.org/W2885347205, https://openalex.org/W2580941851, https://openalex.org/W1978468065, https://openalex.org/W2995983504, https://openalex.org/W257342135, https://openalex.org/W2765843462, https://openalex.org/W2039362531, https://openalex.org/W2762109701, https://openalex.org/W2290323636
referenced_works_count	37
abstract_inverted_index.IV	148
abstract_inverted_index.UV	54
abstract_inverted_index.VI	163
abstract_inverted_index.an	5
abstract_inverted_index.at	60
abstract_inverted_index.bw	153, 157, 160, 168, 171
abstract_inverted_index.by	44, 57, 74, 232
abstract_inverted_index.in	46, 182, 195
abstract_inverted_index.is	26
abstract_inverted_index.of	15, 31, 106, 161, 172, 187, 249, 253, 261
abstract_inverted_index.on	28, 120, 185
abstract_inverted_index.to	258
abstract_inverted_index.AAE	92
abstract_inverted_index.FDA	262
abstract_inverted_index.GAE	97
abstract_inverted_index.SEM	75
abstract_inverted_index.TAC	90
abstract_inverted_index.TRP	95
abstract_inverted_index.XRD	70
abstract_inverted_index.and	20, 41, 64, 71, 94, 149, 158, 164, 169, 176, 198, 217, 244, 251
abstract_inverted_index.bw,	139
abstract_inverted_index.the	259
abstract_inverted_index.two	122
abstract_inverted_index.was	51, 67, 118, 230
abstract_inverted_index.(1:1	123
abstract_inverted_index.CAT,	204
abstract_inverted_index.DPPH	82
abstract_inverted_index.GSH)	205
abstract_inverted_index.POD,	203
abstract_inverted_index.bw),	147
abstract_inverted_index.gene	208
abstract_inverted_index.have	17
abstract_inverted_index.into	128
abstract_inverted_index.lead	257
abstract_inverted_index.nm).	77
abstract_inverted_index.peak	59
abstract_inverted_index.rats	108, 126
abstract_inverted_index.size	65
abstract_inverted_index.that	112, 212
abstract_inverted_index.were	100, 114, 180
abstract_inverted_index.with	10, 102, 109, 136, 151, 166
abstract_inverted_index.(SOD,	202
abstract_inverted_index.MCZNP	173
abstract_inverted_index.Serum	175
abstract_inverted_index.Shape	62
abstract_inverted_index.based	27
abstract_inverted_index.drug.	264
abstract_inverted_index.forty	121
abstract_inverted_index.found	181
abstract_inverted_index.group	132
abstract_inverted_index.male:	124
abstract_inverted_index.mg/g)	93, 98
abstract_inverted_index.plant	8, 16
abstract_inverted_index.range	184
abstract_inverted_index.rats.	48
abstract_inverted_index.serum	196
abstract_inverted_index.seven	129
abstract_inverted_index.study	25
abstract_inverted_index.using	35, 53, 69, 238
abstract_inverted_index.would	256
abstract_inverted_index.(23nm)	66
abstract_inverted_index.(32.06	76
abstract_inverted_index.1ml/kg	138, 152
abstract_inverted_index.363nm.	61
abstract_inverted_index.Leaves	14
abstract_inverted_index.MCZNP,	162
abstract_inverted_index.MCZNPs	78, 110, 113, 189, 223, 250
abstract_inverted_index.active	11
abstract_inverted_index.alone.	174
abstract_inverted_index.caused	43
abstract_inverted_index.enzyme	178
abstract_inverted_index.female	107
abstract_inverted_index.group;	142
abstract_inverted_index.normal	183
abstract_inverted_index.stress	216, 226
abstract_inverted_index.trials	248
abstract_inverted_index.values	99
abstract_inverted_index.(saline	133
abstract_inverted_index.Initial	104
abstract_inverted_index.against	39
abstract_inverted_index.control	141
abstract_inverted_index.divided	127
abstract_inverted_index.enzymes	201
abstract_inverted_index.female)	125
abstract_inverted_index.further	72
abstract_inverted_index.groups;	130
abstract_inverted_index.levels.	206
abstract_inverted_index.lowered	191
abstract_inverted_index.markers	179, 197, 220
abstract_inverted_index.possess	79
abstract_inverted_index.showing	58
abstract_inverted_index.visible	55
abstract_inverted_index.150ml/kg	156, 167
abstract_inverted_index.300mg/kg	159, 170
abstract_inverted_index.Clinical	247
abstract_inverted_index.However,	207
abstract_inverted_index.Whereas,	222
abstract_inverted_index.activity	87
abstract_inverted_index.analysis	210
abstract_inverted_index.approved	263
abstract_inverted_index.elevated	214
abstract_inverted_index.enriched	9
abstract_inverted_index.examined	231
abstract_inverted_index.markers.	227
abstract_inverted_index.restored	199
abstract_inverted_index.revealed	111, 211
abstract_inverted_index.toxicity	42
abstract_inverted_index.µg/mL),	84
abstract_inverted_index.(200mg/kg	146
abstract_inverted_index.</sub>and	155
abstract_inverted_index.CCl<sub>4	143, 154, 192
abstract_inverted_index.I-control	131
abstract_inverted_index.confirmed	52, 73
abstract_inverted_index.estimated	68
abstract_inverted_index.evaluated	119
abstract_inverted_index.exhibited	241
abstract_inverted_index.formation	50
abstract_inverted_index.important	6
abstract_inverted_index.medicinal	7
abstract_inverted_index.oxidative	215, 225
abstract_inverted_index.potential	117
abstract_inverted_index.secondary	12
abstract_inverted_index.treatment	105
abstract_inverted_index.(44.3±0.6	83
abstract_inverted_index.(47.5±0.9	96
abstract_inverted_index.(52.3±0.9	91
abstract_inverted_index.Hepatocyte	228
abstract_inverted_index.II-treated	135
abstract_inverted_index.V-injected	150
abstract_inverted_index.abilities,	81
abstract_inverted_index.comparable	101
abstract_inverted_index.elevations	194
abstract_inverted_index.expression	209
abstract_inverted_index.mechanisms	255
abstract_inverted_index.morphology	229
abstract_inverted_index.non-toxic.	115
abstract_inverted_index.potential.	246
abstract_inverted_index.properties	30
abstract_inverted_index.scavenging	86
abstract_inverted_index.standards.	103
abstract_inverted_index.superoxide	85
abstract_inverted_index.suppressed	224
abstract_inverted_index.underlying	254
abstract_inverted_index.zinc-oxide	32
abstract_inverted_index.(hexagonal)	63
abstract_inverted_index.</bold>This	24
abstract_inverted_index.</italic>is	4
abstract_inverted_index.antioxidant	80, 177, 200, 245
abstract_inverted_index.development	260
abstract_inverted_index.exceptional	242
abstract_inverted_index.properties.	22
abstract_inverted_index.synthesized	34, 237
abstract_inverted_index.upregulated	218
abstract_inverted_index.(P<0.05).	221
abstract_inverted_index.III-positive	140
abstract_inverted_index.hypoglycemic	21
abstract_inverted_index.inflammation	40
abstract_inverted_index.inflammatory	219
abstract_inverted_index.metabolites.	13
abstract_inverted_index.spectroscopy	56
abstract_inverted_index.water-0.9%),	134
abstract_inverted_index.</sub>(1ml/kg	144
abstract_inverted_index.</sub>induced	193
abstract_inverted_index.antibacterial	19
abstract_inverted_index.bw)+silymarin	145
abstract_inverted_index.investigation	252
abstract_inverted_index.nanoparticles	33
abstract_inverted_index.significantly	190
abstract_inverted_index.<bold>Results:	23
abstract_inverted_index.Sprague-Dawley	47
abstract_inverted_index.investigation.	234
abstract_inverted_index.</bold>µg/mL),	89
abstract_inverted_index.CCl<sub>4</sub>	45, 137, 213
abstract_inverted_index.coromandelianum	3, 37
abstract_inverted_index.(27.6±0.9<bold>	88
abstract_inverted_index.Nanoparticle’s	49
abstract_inverted_index.VII-administered	165
abstract_inverted_index.</italic>(MCZNPs)	38
abstract_inverted_index.<bold>Background:	1
abstract_inverted_index.<bold>Conclusion:	235
abstract_inverted_index.Anti-inflammatory	116
abstract_inverted_index.anti-inflammatory	243
abstract_inverted_index.co-administration	186
abstract_inverted_index.hepato-protective	29
abstract_inverted_index.histopathological	233
abstract_inverted_index.<italic>Malvastrum	36, 239
abstract_inverted_index.anti-inflammatory,	18
abstract_inverted_index.</bold>Nanoparticles	236
abstract_inverted_index.<title>Abstract</title>	0
abstract_inverted_index.MCZNPs+CCl<sub>4</sub>.	188
abstract_inverted_index.coromandelianum</italic>	240
abstract_inverted_index.</bold><italic>Malvastrum	2
cited_by_percentile_year
countries_distinct_count	3
institutions_distinct_count	9
citation_normalized_percentile.value	0.05565746
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False