“NoTaMe”: Workflow for Non-Targeted LC-MS Metabolic Profiling Article Swipe
Marietta Kokla
,
Anton Klåvus
,
Stefania Noerman
,
Ville Koistinen
,
Marjo Tuomainen
,
Iman Zarei
,
Topi Meuronen
,
Merja R. Häkkinen
,
Soile Rummukainen
,
Ambrin Farizah Babu
,
Taisa Sallinen
,
Olli Kärkkäinen
,
Jussi Paananen
,
David Broadhurst
,
Carl Brunius
,
Kati Hanhineva
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.20944/preprints202002.0019.v1
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.20944/preprints202002.0019.v1
Metabolomics analysis generates vast arrays of data, necessitating comprehensive workflows involving expertise in analytics, biochemistry and bioinformatics, in order to provide coherent and high-quality data that enables discovery of robust and biologically significant metabolic findings. In this protocol article, we introduce NoTaMe, an analytical workflow for non-targeted metabolic profiling approaches utilizing liquid chromatography–mass spectrometry analysis. We provide an overview of lab protocols and statistical methods that we commonly practice for the analysis of nutritional metabolomics data. The paper is divided into three main sections: the first and second sections introducing the background and the study designs available for metabolomics research, and the third section describing in detail the steps of the main methods and protocols used to produce, preprocess and statistically analyze metabolomics data, and finally to identify and interpret the compounds that have emerged as interesting.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.20944/preprints202002.0019.v1
- https://www.preprints.org/manuscript/202002.0019/v1/download
- OA Status
- green
- Cited By
- 1
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3125008616
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3125008616Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.20944/preprints202002.0019.v1Digital Object Identifier
- Title
-
“NoTaMe”: Workflow for Non-Targeted LC-MS Metabolic ProfilingWork title
- Type
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preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2020Year of publication
- Publication date
-
2020-02-03Full publication date if available
- Authors
-
Marietta Kokla, Anton Klåvus, Stefania Noerman, Ville Koistinen, Marjo Tuomainen, Iman Zarei, Topi Meuronen, Merja R. Häkkinen, Soile Rummukainen, Ambrin Farizah Babu, Taisa Sallinen, Olli Kärkkäinen, Jussi Paananen, David Broadhurst, Carl Brunius, Kati HanhinevaList of authors in order
- Landing page
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https://doi.org/10.20944/preprints202002.0019.v1Publisher landing page
- PDF URL
-
https://www.preprints.org/manuscript/202002.0019/v1/downloadDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.preprints.org/manuscript/202002.0019/v1/downloadDirect OA link when available
- Concepts
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Workflow, Metabolomics, Profiling (computer programming), Computer science, Analytics, Data analysis, Data mining, Data science, Protocol (science), Computational biology, Bioinformatics, Database, Biology, Medicine, Operating system, Alternative medicine, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
- Citations by year (recent)
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2020: 1Per-year citation counts (last 5 years)
- References (count)
-
52Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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