An accurate standardization protocol for heating efficiency determination of 3D printed magnetic bone scaffolds Article Swipe
Antonios Makridis
,
Konstantina Kazeli
,
Pavlos Kyriazopoulos
,
Νikolaos Μaniotis
,
Theodoros Samaras
,
M. Angelakeris
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1088/1361-6463/ac85c8
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1088/1361-6463/ac85c8
Last decade, three-dimensional (3D) printing technology has emerged as a useful tool for meticulously fabricated scaffolds with high precision and accuracy, resulting in intricately detailed biomimetic 3D structures. To this end, nowadays, magnetic scaffolds are becoming increasingly attractive in tissue engineering, due to their ability not only to promote bone tissue formation, bone repair, and regeneration, but at the same time allow for nanoscale drug delivery. Although there has been a lot of research effort on the fabrication of bone scaffolds in the last few years, their perspectives as multifunctional magnetic hyperthermia agents remain an open issue. This emerging, uninvestigated research field requires a carefully designed framework to produce reliable results. This work focuses on establishing such a framework by proposing a standardization protocol with certain experimental steps for an accurate evaluation of the heating efficiency of the 3D printed magnetic scaffolds bone phantoms. The specific indexes of specific absorption rate and specific loss power are carefully determined and calculated here to enhance the differences in the heating experimental approaches that have been followed until now between magnetic nanoparticles and magnetic bone scaffolds. Meanwhile, the heating evaluation cases that one can find in magnetic hyperthermia are separately defined and analyzed with their suited experimental protocols. Firstly, 3D printed magnetic scaffolds are designed and fabricated. Secondly, they are evaluated as heating carriers. Agarose is exploited here not only as a tissue mimicking phantom, but also as a heat diffusion medium through the scaffold’s pores. A reliable estimation sequence of the heating efficiency, i.e. the specific absorption rate of the magnetic scaffolds, is introduced, analyzed and discussed in conjunction with the specific loss power, which is the respective quantitative index for evaluating the magnetic nanoparticles’ heating efficacy. Finally, this work proposes how the fabrication procedure of the 3D printed scaffolds can be guided by the magnetic particle hyperthermia literature results, as to increase the scaffolds heating efficiency through printing parameters. Consequently, this work deals with the methodology to create a reproducible and accurate protocol for assessing the heating efficiency of magnetic scaffolds serving as bone implants for deep-seated hyperthermia tumor treatment.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1088/1361-6463/ac85c8
- https://iopscience.iop.org/article/10.1088/1361-6463/ac85c8/pdf
- OA Status
- hybrid
- Cited By
- 15
- References
- 33
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4289295480
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4289295480Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1088/1361-6463/ac85c8Digital Object Identifier
- Title
-
An accurate standardization protocol for heating efficiency determination of 3D printed magnetic bone scaffoldsWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2022Year of publication
- Publication date
-
2022-08-01Full publication date if available
- Authors
-
Antonios Makridis, Konstantina Kazeli, Pavlos Kyriazopoulos, Νikolaos Μaniotis, Theodoros Samaras, M. AngelakerisList of authors in order
- Landing page
-
https://doi.org/10.1088/1361-6463/ac85c8Publisher landing page
- PDF URL
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https://iopscience.iop.org/article/10.1088/1361-6463/ac85c8/pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
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https://iopscience.iop.org/article/10.1088/1361-6463/ac85c8/pdfDirect OA link when available
- Concepts
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Materials science, Biomedical engineering, Scaffold, Heat generation, Magnetic nanoparticles, Nanotechnology, 3d printed, Agarose, Magnetic hyperthermia, Computer science, Nanoparticle, Chemistry, Engineering, Thermodynamics, Physics, ChromatographyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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15Total citation count in OpenAlex
- Citations by year (recent)
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2025: 6, 2024: 3, 2023: 5, 2022: 1Per-year citation counts (last 5 years)
- References (count)
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33Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| publication_date | 2022-08-01 |
| publication_year | 2022 |
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