An Activity‐Based Nanosensor for Minimally‐Invasive Measurement of Protease Activity in Traumatic Brain Injury Article Swipe
Julia A. Kudryashev
,
Marianne I. Madias
,
Rebecca M. Kandell
,
Queenie X. Lin
,
Ester J. Kwon
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/adfm.202300218
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/adfm.202300218
Current screening and diagnostic tools for traumatic brain injury (TBI) have limitations in sensitivity and prognostication. Aberrant protease activity is a central process that drives disease progression in TBI and is associated with worsened prognosis, thus direct measurements of protease activity can provide more diagnostic information. In this study, a nanosensor is engineered to release a measurable signal into the blood and urine in response to activity from the TBI‐associated protease calpain. Readouts from the nanosensor are designed to be compatible with ELISA and lateral flow assays, clinically‐relevant assay modalities. In a mouse model of TBI, the nanosensor sensitivity is enhanced when ligands that target hyaluronic acid are added. In evaluation of mice with mild or severe injuries, the nanosensor identifies mild TBI with a higher sensitivity than the biomarker glial fibrillary acidic protein (GFAP). This nanosensor technology allows for measurement of TBI‐associated proteases without the need to directly access brain tissue and has the potential to complement existing TBI diagnostic tools.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/adfm.202300218
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adfm.202300218
- OA Status
- hybrid
- Cited By
- 14
- References
- 72
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4365509583
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4365509583Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/adfm.202300218Digital Object Identifier
- Title
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An Activity‐Based Nanosensor for Minimally‐Invasive Measurement of Protease Activity in Traumatic Brain InjuryWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-04-14Full publication date if available
- Authors
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Julia A. Kudryashev, Marianne I. Madias, Rebecca M. Kandell, Queenie X. Lin, Ester J. KwonList of authors in order
- Landing page
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https://doi.org/10.1002/adfm.202300218Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adfm.202300218Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adfm.202300218Direct OA link when available
- Concepts
-
Nanosensor, Traumatic brain injury, Materials science, Protease, Nanotechnology, Biomedical engineering, Biology, Medicine, Biochemistry, Psychiatry, EnzymeTop concepts (fields/topics) attached by OpenAlex
- Cited by
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14Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4, 2024: 8, 2023: 2Per-year citation counts (last 5 years)
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72Number of works referenced by this work
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-
10Other works algorithmically related by OpenAlex
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