An AIE‐active probe for efficient detection and high‐throughput identification of outer membrane vesicles Article Swipe
Fei Wang
,
Po‐Yu Ho
,
Chuen Kam
,
Quanzhi Yang
,
Jinzhao Liu
,
Weiping Wang
,
Engui Zhao
,
Sijie Chen
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/agt2.312
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/agt2.312
Rapid detection and quantification of outer membrane vesicle (OMV) are of both scientific value and clinical implications. However, limited tools are available for investigations of OMVs. Herein, we report a novel fluorescent probe with aggregation‐induced emission (AIE) characteristics, namely, OEO‐TPE‐MEM (OTM), for OMV detection. OTM emits faintly in an aqueous medium, but its fluorescence could be effectively turned on upon interacting with bacteria bodies and OMVs produced by Gram‐negative bacteria. Notably, OTM could provide quantitative information on bacterial membrane remodeling and OMV secretion and be applied to high‐throughput screening of OMV‐inducing agents. This study presents a powerful AIE probe for imaging and quantitative analysis of bacteria envelop and derived OMVs, which might be applied for evaluating research and clinical antimicrobial materials in future studies.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/agt2.312
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/agt2.312
- OA Status
- gold
- Cited By
- 24
- References
- 47
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4319838906
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4319838906Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/agt2.312Digital Object Identifier
- Title
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An AIE‐active probe for efficient detection and high‐throughput identification of outer membrane vesiclesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-01-10Full publication date if available
- Authors
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Fei Wang, Po‐Yu Ho, Chuen Kam, Quanzhi Yang, Jinzhao Liu, Weiping Wang, Engui Zhao, Sijie ChenList of authors in order
- Landing page
-
https://doi.org/10.1002/agt2.312Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/agt2.312Direct link to full text PDF
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/agt2.312Direct OA link when available
- Concepts
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Bacteria, Vesicle, Membrane, Fluorescence, Chemistry, Bacterial outer membrane, Biophysics, High-throughput screening, Nanotechnology, Secretion, Biology, Biochemistry, Materials science, Physics, Quantum mechanics, Escherichia coli, Genetics, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
24Total citation count in OpenAlex
- Citations by year (recent)
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2025: 8, 2024: 13, 2023: 3Per-year citation counts (last 5 years)
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47Number of works referenced by this work
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-
10Other works algorithmically related by OpenAlex
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