An Anatomically Realistic Simulation Framework for 3D Ultrasound Localization Microscopy Article Swipe
Hatim Belgharbi
,
Jonathan Porée
,
Rafat Damseh
,
Vincent Perrot
,
Léo Milecki
,
Patrick Delafontaine-Martel
,
Frédéric Lesage
,
Jean Provost
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1109/ojuffc.2023.3235766
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1109/ojuffc.2023.3235766
The resolution of 3D Ultrasound Localization Microscopy (ULM) is determined by acquisition parameters such as frequency and transducer geometry but also by microbubble (MB) concentration, which is linked to the total acquisition time needed to sample the vascular tree at different scales. In this study, we introduce a novel 3D anatomically-realistic ULM simulation framework based on two-photon microscopy (2PM) and in-vivo MB perfusion dynamics. As a proof of concept, using metrics such as MB localization error, MB count and network filling, we quantify the effect of MB concentration and PSF volume by varying probe transmit frequency (3-15 MHz). We found that while low frequencies can achieve sub-wavelength resolution as predicted by theory, they are also associated with prolonged acquisition times to map smaller vessels, thus limiting effective resolution (i.e., the smallest vessel that can be reconstructed). A linear relationship was found between the maximal MB concentration and the inverse of the point spread function (PSF) volume. Since inverse PSF volume roughly scales cubically with frequency, the reconstruction of the equivalent of 10 minutes at 15 MHz would require hours at 3 MHz. We expect that these findings can be leveraged to achieve effective reconstruction and serve as a guide for choosing optimal MB concentrations in ULM.
Related Topics
Concepts
Point spread function
Microscopy
Resolution (logic)
Transducer
Image resolution
Volume (thermodynamics)
Materials science
Inverse
Ultrasound
Inverse problem
Wavelength
Biomedical engineering
Optics
Computer science
Physics
Acoustics
Mathematics
Artificial intelligence
Geometry
Mathematical analysis
Medicine
Quantum mechanics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1109/ojuffc.2023.3235766
- https://ieeexplore.ieee.org/ielx7/9292640/10031625/10013486.pdf
- OA Status
- hybrid
- Cited By
- 21
- References
- 57
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4315489566
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4315489566Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1109/ojuffc.2023.3235766Digital Object Identifier
- Title
-
An Anatomically Realistic Simulation Framework for 3D Ultrasound Localization MicroscopyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-01-01Full publication date if available
- Authors
-
Hatim Belgharbi, Jonathan Porée, Rafat Damseh, Vincent Perrot, Léo Milecki, Patrick Delafontaine-Martel, Frédéric Lesage, Jean ProvostList of authors in order
- Landing page
-
https://doi.org/10.1109/ojuffc.2023.3235766Publisher landing page
- PDF URL
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https://ieeexplore.ieee.org/ielx7/9292640/10031625/10013486.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
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https://ieeexplore.ieee.org/ielx7/9292640/10031625/10013486.pdfDirect OA link when available
- Concepts
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Point spread function, Microscopy, Resolution (logic), Transducer, Image resolution, Volume (thermodynamics), Materials science, Inverse, Ultrasound, Inverse problem, Wavelength, Biomedical engineering, Optics, Computer science, Physics, Acoustics, Mathematics, Artificial intelligence, Geometry, Mathematical analysis, Medicine, Quantum mechanicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
21Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 7, 2024: 12, 2023: 2Per-year citation counts (last 5 years)
- References (count)
-
57Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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