An Association of Takotsubo Cardiomyopathy with Guillain-Barré Syndrome Article Swipe
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· 2022
· Open Access
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Taylor A Huhta,1 Lydia Ran,1 Craig W Cooper,1 Michael J Davis,1 Joshua Kornbluth,2 Deeb N Salem1 1Department of Medicine, Tufts Medical Center, Boston, MA, USA; 2Department of Neurology, Tufts Medical Center, Boston, MA, USACorrespondence: Taylor A Huhta, Tufts Medical Center, Department of Medicine, 800 Washington Street, Boston, MA, 02111, USA, Tel +1 508 237 6242, Email [email protected]: The association between Guillain-Barré syndrome (GBS) and Takotsubo cardiomyopathy (TC) has been appreciated for over two decades, while the physiological mechanisms between the two conditions are less so. In the time since, the progress in understanding molecular mechanisms and the accumulation of reported cases in the literature together have provided the beginnings for a deeper understanding of the disease pathways connecting these two conditions.Methods: Case report.Results: We report a 75-year-old woman with a history of prior TC who presented with symmetric bilateral paresthesias and weakness all preceded by symptoms concerning for an upper respiratory infection. The patient required intubation shortly after arrival due to respiratory failure, and routine electrocardiogram found evidence of ST-elevation myocardial infarction in multiple leads. Subsequent echocardiogram revealed findings consistent with TC, and electromyographic evaluation confirmed GBS. The patient clinically improved with plasmapheresis and had returned to her cardiac and neurologic baselines on outpatient follow-up.Conclusion: GBS contributes directly to the pathogenesis of TC, both through direct action on cardiac nerves and an increase in resting sympathetic tone. While the stress of intubation likely contributes to a sympathogenic state within GBS, it is unlikely the principal factor predicting the development of TC within this unique subset of patients. TC should be considered in any patient with an acute neuropathy whenever signs of progressive dysautonomia are present.Keywords: Takotsubo cardiomyopathy, myocardial stunning, Guillain-Barré syndrome, dysautonomia
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doaj.org/article/634205375b124423a98bdb2e7225bf8d
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- green
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- 10
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https://openalex.org/W4387000442Canonical identifier for this work in OpenAlex
- Title
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An Association of Takotsubo Cardiomyopathy with Guillain-Barré SyndromeWork title
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-04-01Full publication date if available
- Authors
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Huhta TA, Ran L, Cooper Cw, Davis Mj, Joshua Kornbluth, Salem DnList of authors in order
- Landing page
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https://doaj.org/article/634205375b124423a98bdb2e7225bf8dPublisher landing page
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
- OA URL
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https://doaj.org/article/634205375b124423a98bdb2e7225bf8dDirect OA link when available
- Concepts
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Cardiomyopathy, Guillain-Barre syndrome, Takotsubo syndrome, Association (psychology), Medicine, Cardiology, Internal medicine, Psychology, Psychiatry, Heart failure, PsychotherapistTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.Washington | 44 |
| abstract_inverted_index.beginnings | 108 |
| abstract_inverted_index.clinically | 189 |
| abstract_inverted_index.concerning | 146 |
| abstract_inverted_index.conditions | 81 |
| abstract_inverted_index.connecting | 117 |
| abstract_inverted_index.considered | 260 |
| abstract_inverted_index.consistent | 179 |
| abstract_inverted_index.evaluation | 184 |
| abstract_inverted_index.infarction | 171 |
| abstract_inverted_index.infection. | 151 |
| abstract_inverted_index.intubation | 155, 231 |
| abstract_inverted_index.literature | 103 |
| abstract_inverted_index.mechanisms | 77, 94 |
| abstract_inverted_index.myocardial | 170, 277 |
| abstract_inverted_index.neurologic | 200 |
| abstract_inverted_index.neuropathy | 267 |
| abstract_inverted_index.outpatient | 203 |
| abstract_inverted_index.predicting | 246 |
| abstract_inverted_index.1Department | 16 |
| abstract_inverted_index.2Department | 25 |
| abstract_inverted_index.75-year-old | 126 |
| abstract_inverted_index.Kornbluth,2 | 12 |
| abstract_inverted_index.appreciated | 69 |
| abstract_inverted_index.association | 58 |
| abstract_inverted_index.contributes | 206, 233 |
| abstract_inverted_index.development | 248 |
| abstract_inverted_index.progressive | 271 |
| abstract_inverted_index.respiratory | 150, 161 |
| abstract_inverted_index.sympathetic | 225 |
| abstract_inverted_index.ST-elevation | 169 |
| abstract_inverted_index.accumulation | 97 |
| abstract_inverted_index.dysautonomia | 272, 281 |
| abstract_inverted_index.paresthesias | 139 |
| abstract_inverted_index.pathogenesis | 210 |
| abstract_inverted_index.physiological | 76 |
| abstract_inverted_index.sympathogenic | 236 |
| abstract_inverted_index.understanding | 92, 112 |
| abstract_inverted_index.cardiomyopathy | 65 |
| abstract_inverted_index.echocardiogram | 176 |
| abstract_inverted_index.plasmapheresis | 192 |
| abstract_inverted_index.Guillain-Barré | 60, 279 |
| abstract_inverted_index.cardiomyopathy, | 276 |
| abstract_inverted_index.report.Results: | 122 |
| abstract_inverted_index.electrocardiogram | 165 |
| abstract_inverted_index.electromyographic | 183 |
| abstract_inverted_index.present.Keywords: | 274 |
| abstract_inverted_index.USACorrespondence: | 33 |
| abstract_inverted_index.conditions.Methods: | 120 |
| abstract_inverted_index.follow-up.Conclusion: | 204 |
| [email protected]: | 56 |
| cited_by_percentile_year | |
| countries_distinct_count | 0 |
| institutions_distinct_count | 6 |
| citation_normalized_percentile.value | 0.37053457 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |