An easy assay to detect autoantibodies neutralizing cytokines in subjects with critical infections Article Swipe
Nicola Donadel
,
Alessandra Tesser
,
Erica Valencic
,
Eleonora De Martino
,
Valentina Boz
,
Alessia Pin
,
Francesca Zorat
,
Gabriele Pozzato
,
Alberto Tommasini
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.jim.2024.113696
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.jim.2024.113696
Autoantibodies against type I interferon (IFN) are associated with a worse outcome in COVID-19. The measurement of cytokine-neutralizing autoantibodies has been limited, hindering understanding of their role in clinical practice. We showed that an easy and reliable assay can be reproduced and validated to measure the neutralizing potency of autoantibodies directed to type I or type II IFN. Identifying of anti-cytokine autoantibodies might reflect on early treatments for subsequent infections, such as with antivirals or virus-neutralizing monoclonal antibodies.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.jim.2024.113696
- OA Status
- hybrid
- Cited By
- 1
- References
- 14
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4398784991Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.jim.2024.113696Digital Object Identifier
- Title
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An easy assay to detect autoantibodies neutralizing cytokines in subjects with critical infectionsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-05-24Full publication date if available
- Authors
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Nicola Donadel, Alessandra Tesser, Erica Valencic, Eleonora De Martino, Valentina Boz, Alessia Pin, Francesca Zorat, Gabriele Pozzato, Alberto TommasiniList of authors in order
- Landing page
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https://doi.org/10.1016/j.jim.2024.113696Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1016/j.jim.2024.113696Direct OA link when available
- Concepts
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Autoantibody, Immunology, Monoclonal antibody, Cytokine, Neutralizing antibody, Medicine, Antibody, Virology, MonoclonalTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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14Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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