An Energy Efficient Thermally Regulated Optical Spectroscopy Cell for Lab-on-Chip Devices: Applied to Nitrate Detection Article Swipe
Benjamin Murphy
,
Edward Luy
,
Katerina L. Panzica
,
G. Johnson
,
Vincent J. Sieben
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/mi12080861
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/mi12080861
Reagent-based colorimetric analyzers often heat the fluid under analysis for improved reaction kinetics, whilst also aiming to minimize energy use per measurement. Here, a novel method of conserving heat energy on such microfluidic systems is presented. Our design reduces heat transfer to the environment by surrounding the heated optical cell on four sides with integral air pockets, thereby realizing an insulated and suspended bridge structure. Our design was simulated in COMSOL Multiphysics and verified in a polymethyl methacrylate (PMMA) device. We evaluate the effectiveness of the insulated design by comparing it to a non-insulated cell. For temperatures up to 55 °C, the average power consumption was reduced by 49.3% in the simulation and 40.2% in the experiment. The designs were then characterized with the vanadium and Griess reagent assay for nitrate at 35 °C. Nitrate concentrations from 0.25 µM to 50 µM were tested and yielded the expected linear relationship with a limit of detection of 20 nM. We show a reduction in energy consumption from 195 J to 119 J per 10 min measurement using only 4 µL of fluid. Efficient heating on-chip will have broad applicability to numerous colorimetric assays.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/mi12080861
- https://www.mdpi.com/2072-666X/12/8/861/pdf?version=1626958958
- OA Status
- gold
- Cited By
- 7
- References
- 46
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3184288797
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3184288797Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/mi12080861Digital Object Identifier
- Title
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An Energy Efficient Thermally Regulated Optical Spectroscopy Cell for Lab-on-Chip Devices: Applied to Nitrate DetectionWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-07-22Full publication date if available
- Authors
-
Benjamin Murphy, Edward Luy, Katerina L. Panzica, G. Johnson, Vincent J. SiebenList of authors in order
- Landing page
-
https://doi.org/10.3390/mi12080861Publisher landing page
- PDF URL
-
https://www.mdpi.com/2072-666X/12/8/861/pdf?version=1626958958Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2072-666X/12/8/861/pdf?version=1626958958Direct OA link when available
- Concepts
-
Multiphysics, Reagent, Lab-on-a-chip, Materials science, Microfluidics, Analytical Chemistry (journal), Energy consumption, Chip, Detection limit, Chemistry, Process engineering, Nanotechnology, Chromatography, Thermodynamics, Electrical engineering, Engineering, Physical chemistry, Finite element method, PhysicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
7Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2023: 1, 2022: 3, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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46Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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