An estimate of the longitudinal pace of aging from a single brain scan predicts dementia conversion, morbidity, and mortality Article Swipe
Ethan T. Whitman
,
Maxwell L. Elliott
,
Annchen R. Knodt
,
Wickliffe C. Abraham
,
Tim Anderson
,
Nick Cutfield
,
Sean Hogan
,
David Ireland
,
Tracy R. Melzer
,
Sandhya Ramrakha
,
Karen Sugden
,
Reremoana Theodore
,
Benjamin Williams
,
Avshalom Caspi
,
Terrie E. Moffitt
,
Ahmad R. Hariri
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.08.19.608305
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.08.19.608305
To understand how aging affects functional decline and increases disease risk, it is necessary to develop accurate and reliable measures of how fast a person is aging. Epigenetic clocks measure aging but require DNA methylation data, which many studies lack. Using data from the Dunedin Study, we introduce an accurate and reliable measure for the rate of longitudinal aging derived from cross-sectional brain MRI: the Dunedin Pace of Aging Calculated from NeuroImaging or DunedinPACNI. Exporting this measure to the Alzheimer’s Disease Neuroimaging Initiative and UK Biobank datasets revealed that faster DunedinPACNI predicted participants’ cognitive impairment, accelerated brain atrophy, and conversion to diagnosed dementia. Underscoring close links between longitudinal aging of the body and brain, faster DunedinPACNI also predicted physical frailty, poor health, future chronic diseases, and mortality in older adults. Furthermore, DunedinPACNI followed an established socioeconomic health gradient with people of lower socioeconomic status showing faster DunedinPACNI. Associations between DunedinPACNI and cognitive impairment were replicated in BrainLat, a sample of Latin American patients with dementia. When compared to brain age gap, an existing MRI aging biomarker, DunedinPACNI was similarly or more strongly related to clinical outcomes. DunedinPACNI is a “next generation” MRI measure that will be made publicly available to the research community to help accelerate aging research and evaluate the effectiveness of dementia prevention and anti-aging strategies.
Related Topics
Concepts
Dementia
Neuroimaging
Brain aging
Biobank
Alzheimer's Disease Neuroimaging Initiative
Gerontology
Longitudinal study
Successful aging
Aging brain
Medicine
Alzheimer's disease
Atrophy
Biomarker
Healthy aging
Cognitive decline
Psychology
Cognition
Physical medicine and rehabilitation
Disease
Neuroscience
Bioinformatics
Internal medicine
Pathology
Biology
Biochemistry
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2024.08.19.608305
- https://www.biorxiv.org/content/biorxiv/early/2024/08/22/2024.08.19.608305.full.pdf
- OA Status
- green
- Cited By
- 1
- References
- 130
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401750665
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4401750665Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2024.08.19.608305Digital Object Identifier
- Title
-
An estimate of the longitudinal pace of aging from a single brain scan predicts dementia conversion, morbidity, and mortalityWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-08-22Full publication date if available
- Authors
-
Ethan T. Whitman, Maxwell L. Elliott, Annchen R. Knodt, Wickliffe C. Abraham, Tim Anderson, Nick Cutfield, Sean Hogan, David Ireland, Tracy R. Melzer, Sandhya Ramrakha, Karen Sugden, Reremoana Theodore, Benjamin Williams, Avshalom Caspi, Terrie E. Moffitt, Ahmad R. HaririList of authors in order
- Landing page
-
https://doi.org/10.1101/2024.08.19.608305Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2024/08/22/2024.08.19.608305.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2024/08/22/2024.08.19.608305.full.pdfDirect OA link when available
- Concepts
-
Dementia, Neuroimaging, Brain aging, Biobank, Alzheimer's Disease Neuroimaging Initiative, Gerontology, Longitudinal study, Successful aging, Aging brain, Medicine, Alzheimer's disease, Atrophy, Biomarker, Healthy aging, Cognitive decline, Psychology, Cognition, Physical medicine and rehabilitation, Disease, Neuroscience, Bioinformatics, Internal medicine, Pathology, Biology, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1Per-year citation counts (last 5 years)
- References (count)
-
130Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4401750665 |
|---|---|
| doi | https://doi.org/10.1101/2024.08.19.608305 |
| ids.doi | https://doi.org/10.1101/2024.08.19.608305 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/39229058 |
| ids.openalex | https://openalex.org/W4401750665 |
| fwci | 0.89620974 |
| type | preprint |
| title | An estimate of the longitudinal pace of aging from a single brain scan predicts dementia conversion, morbidity, and mortality |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T10009 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998000264167786 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2738 |
| topics[0].subfield.display_name | Psychiatry and Mental health |
| topics[0].display_name | Dementia and Cognitive Impairment Research |
| topics[1].id | https://openalex.org/T10235 |
| topics[1].field.id | https://openalex.org/fields/33 |
| topics[1].field.display_name | Social Sciences |
| topics[1].score | 0.9909999966621399 |
| topics[1].domain.id | https://openalex.org/domains/2 |
| topics[1].domain.display_name | Social Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/3306 |
| topics[1].subfield.display_name | Health |
| topics[1].display_name | Health disparities and outcomes |
| topics[2].id | https://openalex.org/T11983 |
| topics[2].field.id | https://openalex.org/fields/32 |
| topics[2].field.display_name | Psychology |
| topics[2].score | 0.9908999800682068 |
| topics[2].domain.id | https://openalex.org/domains/2 |
| topics[2].domain.display_name | Social Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/3204 |
| topics[2].subfield.display_name | Developmental and Educational Psychology |
| topics[2].display_name | Identity, Memory, and Therapy |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2779483572 |
| concepts[0].level | 3 |
| concepts[0].score | 0.7573782205581665 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q83030 |
| concepts[0].display_name | Dementia |
| concepts[1].id | https://openalex.org/C58693492 |
| concepts[1].level | 2 |
| concepts[1].score | 0.7572450041770935 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q551875 |
| concepts[1].display_name | Neuroimaging |
| concepts[2].id | https://openalex.org/C2993665655 |
| concepts[2].level | 3 |
| concepts[2].score | 0.7156375050544739 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q4692577 |
| concepts[2].display_name | Brain aging |
| concepts[3].id | https://openalex.org/C116567970 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5986784100532532 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q864217 |
| concepts[3].display_name | Biobank |
| concepts[4].id | https://openalex.org/C2778373026 |
| concepts[4].level | 4 |
| concepts[4].score | 0.5575876832008362 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q4738819 |
| concepts[4].display_name | Alzheimer's Disease Neuroimaging Initiative |
| concepts[5].id | https://openalex.org/C74909509 |
| concepts[5].level | 1 |
| concepts[5].score | 0.48395445942878723 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q10387 |
| concepts[5].display_name | Gerontology |
| concepts[6].id | https://openalex.org/C2777895361 |
| concepts[6].level | 2 |
| concepts[6].score | 0.48181262612342834 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q1758614 |
| concepts[6].display_name | Longitudinal study |
| concepts[7].id | https://openalex.org/C2778175527 |
| concepts[7].level | 2 |
| concepts[7].score | 0.47541576623916626 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q332154 |
| concepts[7].display_name | Successful aging |
| concepts[8].id | https://openalex.org/C2779695026 |
| concepts[8].level | 3 |
| concepts[8].score | 0.44948890805244446 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q4692577 |
| concepts[8].display_name | Aging brain |
| concepts[9].id | https://openalex.org/C71924100 |
| concepts[9].level | 0 |
| concepts[9].score | 0.44331681728363037 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[9].display_name | Medicine |
| concepts[10].id | https://openalex.org/C502032728 |
| concepts[10].level | 3 |
| concepts[10].score | 0.43838295340538025 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q11081 |
| concepts[10].display_name | Alzheimer's disease |
| concepts[11].id | https://openalex.org/C2781172350 |
| concepts[11].level | 2 |
| concepts[11].score | 0.4355284571647644 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q194520 |
| concepts[11].display_name | Atrophy |
| concepts[12].id | https://openalex.org/C2781197716 |
| concepts[12].level | 2 |
| concepts[12].score | 0.4264053404331207 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q864574 |
| concepts[12].display_name | Biomarker |
| concepts[13].id | https://openalex.org/C3017819807 |
| concepts[13].level | 2 |
| concepts[13].score | 0.4243248701095581 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q332154 |
| concepts[13].display_name | Healthy aging |
| concepts[14].id | https://openalex.org/C2984863031 |
| concepts[14].level | 4 |
| concepts[14].score | 0.4165567457675934 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q83030 |
| concepts[14].display_name | Cognitive decline |
| concepts[15].id | https://openalex.org/C15744967 |
| concepts[15].level | 0 |
| concepts[15].score | 0.39947712421417236 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q9418 |
| concepts[15].display_name | Psychology |
| concepts[16].id | https://openalex.org/C169900460 |
| concepts[16].level | 2 |
| concepts[16].score | 0.3883676826953888 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q2200417 |
| concepts[16].display_name | Cognition |
| concepts[17].id | https://openalex.org/C99508421 |
| concepts[17].level | 1 |
| concepts[17].score | 0.386496365070343 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q2678675 |
| concepts[17].display_name | Physical medicine and rehabilitation |
| concepts[18].id | https://openalex.org/C2779134260 |
| concepts[18].level | 2 |
| concepts[18].score | 0.3793375492095947 |
| concepts[18].wikidata | https://www.wikidata.org/wiki/Q12136 |
| concepts[18].display_name | Disease |
| concepts[19].id | https://openalex.org/C169760540 |
| concepts[19].level | 1 |
| concepts[19].score | 0.3344588875770569 |
| concepts[19].wikidata | https://www.wikidata.org/wiki/Q207011 |
| concepts[19].display_name | Neuroscience |
| concepts[20].id | https://openalex.org/C60644358 |
| concepts[20].level | 1 |
| concepts[20].score | 0.1792202889919281 |
| concepts[20].wikidata | https://www.wikidata.org/wiki/Q128570 |
| concepts[20].display_name | Bioinformatics |
| concepts[21].id | https://openalex.org/C126322002 |
| concepts[21].level | 1 |
| concepts[21].score | 0.15706422924995422 |
| concepts[21].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[21].display_name | Internal medicine |
| concepts[22].id | https://openalex.org/C142724271 |
| concepts[22].level | 1 |
| concepts[22].score | 0.12675461173057556 |
| concepts[22].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[22].display_name | Pathology |
| concepts[23].id | https://openalex.org/C86803240 |
| concepts[23].level | 0 |
| concepts[23].score | 0.08169150352478027 |
| concepts[23].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[23].display_name | Biology |
| concepts[24].id | https://openalex.org/C55493867 |
| concepts[24].level | 1 |
| concepts[24].score | 0.0 |
| concepts[24].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[24].display_name | Biochemistry |
| keywords[0].id | https://openalex.org/keywords/dementia |
| keywords[0].score | 0.7573782205581665 |
| keywords[0].display_name | Dementia |
| keywords[1].id | https://openalex.org/keywords/neuroimaging |
| keywords[1].score | 0.7572450041770935 |
| keywords[1].display_name | Neuroimaging |
| keywords[2].id | https://openalex.org/keywords/brain-aging |
| keywords[2].score | 0.7156375050544739 |
| keywords[2].display_name | Brain aging |
| keywords[3].id | https://openalex.org/keywords/biobank |
| keywords[3].score | 0.5986784100532532 |
| keywords[3].display_name | Biobank |
| keywords[4].id | https://openalex.org/keywords/alzheimers-disease-neuroimaging-initiative |
| keywords[4].score | 0.5575876832008362 |
| keywords[4].display_name | Alzheimer's Disease Neuroimaging Initiative |
| keywords[5].id | https://openalex.org/keywords/gerontology |
| keywords[5].score | 0.48395445942878723 |
| keywords[5].display_name | Gerontology |
| keywords[6].id | https://openalex.org/keywords/longitudinal-study |
| keywords[6].score | 0.48181262612342834 |
| keywords[6].display_name | Longitudinal study |
| keywords[7].id | https://openalex.org/keywords/successful-aging |
| keywords[7].score | 0.47541576623916626 |
| keywords[7].display_name | Successful aging |
| keywords[8].id | https://openalex.org/keywords/aging-brain |
| keywords[8].score | 0.44948890805244446 |
| keywords[8].display_name | Aging brain |
| keywords[9].id | https://openalex.org/keywords/medicine |
| keywords[9].score | 0.44331681728363037 |
| keywords[9].display_name | Medicine |
| keywords[10].id | https://openalex.org/keywords/alzheimers-disease |
| keywords[10].score | 0.43838295340538025 |
| keywords[10].display_name | Alzheimer's disease |
| keywords[11].id | https://openalex.org/keywords/atrophy |
| keywords[11].score | 0.4355284571647644 |
| keywords[11].display_name | Atrophy |
| keywords[12].id | https://openalex.org/keywords/biomarker |
| keywords[12].score | 0.4264053404331207 |
| keywords[12].display_name | Biomarker |
| keywords[13].id | https://openalex.org/keywords/healthy-aging |
| keywords[13].score | 0.4243248701095581 |
| keywords[13].display_name | Healthy aging |
| keywords[14].id | https://openalex.org/keywords/cognitive-decline |
| keywords[14].score | 0.4165567457675934 |
| keywords[14].display_name | Cognitive decline |
| keywords[15].id | https://openalex.org/keywords/psychology |
| keywords[15].score | 0.39947712421417236 |
| keywords[15].display_name | Psychology |
| keywords[16].id | https://openalex.org/keywords/cognition |
| keywords[16].score | 0.3883676826953888 |
| keywords[16].display_name | Cognition |
| keywords[17].id | https://openalex.org/keywords/physical-medicine-and-rehabilitation |
| keywords[17].score | 0.386496365070343 |
| keywords[17].display_name | Physical medicine and rehabilitation |
| keywords[18].id | https://openalex.org/keywords/disease |
| keywords[18].score | 0.3793375492095947 |
| keywords[18].display_name | Disease |
| keywords[19].id | https://openalex.org/keywords/neuroscience |
| keywords[19].score | 0.3344588875770569 |
| keywords[19].display_name | Neuroscience |
| keywords[20].id | https://openalex.org/keywords/bioinformatics |
| keywords[20].score | 0.1792202889919281 |
| keywords[20].display_name | Bioinformatics |
| keywords[21].id | https://openalex.org/keywords/internal-medicine |
| keywords[21].score | 0.15706422924995422 |
| keywords[21].display_name | Internal medicine |
| keywords[22].id | https://openalex.org/keywords/pathology |
| keywords[22].score | 0.12675461173057556 |
| keywords[22].display_name | Pathology |
| keywords[23].id | https://openalex.org/keywords/biology |
| keywords[23].score | 0.08169150352478027 |
| keywords[23].display_name | Biology |
| language | en |
| locations[0].id | doi:10.1101/2024.08.19.608305 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4306402567 |
| locations[0].source.issn | |
| locations[0].source.type | repository |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | |
| locations[0].source.is_core | False |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| locations[0].source.host_organization | https://openalex.org/I2750212522 |
| locations[0].source.host_organization_name | Cold Spring Harbor Laboratory |
| locations[0].source.host_organization_lineage | https://openalex.org/I2750212522 |
| locations[0].license | cc-by-nc-nd |
| locations[0].pdf_url | https://www.biorxiv.org/content/biorxiv/early/2024/08/22/2024.08.19.608305.full.pdf |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc-nd |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.1101/2024.08.19.608305 |
| locations[1].id | pmid:39229058 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | bioRxiv : the preprint server for biology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/39229058 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:11370321 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | bioRxiv |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11370321 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5027144504 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-3208-171X |
| authorships[0].author.display_name | Ethan T. Whitman |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I170897317 |
| authorships[0].affiliations[0].raw_affiliation_string | Duke University |
| authorships[0].institutions[0].id | https://openalex.org/I170897317 |
| authorships[0].institutions[0].ror | https://ror.org/00py81415 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I170897317 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | Duke University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Ethan T. Whitman |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Duke University |
| authorships[1].author.id | https://openalex.org/A5008147082 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-1083-6277 |
| authorships[1].author.display_name | Maxwell L. Elliott |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I2801851002 |
| authorships[1].affiliations[0].raw_affiliation_string | Harvard University |
| authorships[1].institutions[0].id | https://openalex.org/I2801851002 |
| authorships[1].institutions[0].ror | https://ror.org/006v7bf86 |
| authorships[1].institutions[0].type | other |
| authorships[1].institutions[0].lineage | https://openalex.org/I136199984, https://openalex.org/I2801851002 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Harvard University Press |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Maxwell L. Elliott |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Harvard University |
| authorships[2].author.id | https://openalex.org/A5062912691 |
| authorships[2].author.orcid | https://orcid.org/0000-0001-6501-8947 |
| authorships[2].author.display_name | Annchen R. Knodt |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I170897317 |
| authorships[2].affiliations[0].raw_affiliation_string | Duke University |
| authorships[2].institutions[0].id | https://openalex.org/I170897317 |
| authorships[2].institutions[0].ror | https://ror.org/00py81415 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I170897317 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Duke University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Annchen R. Knodt |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Duke University |
| authorships[3].author.id | https://openalex.org/A5078749838 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-9919-0622 |
| authorships[3].author.display_name | Wickliffe C. Abraham |
| authorships[3].countries | NZ |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I80281795 |
| authorships[3].affiliations[0].raw_affiliation_string | University of Otago |
| authorships[3].institutions[0].id | https://openalex.org/I80281795 |
| authorships[3].institutions[0].ror | https://ror.org/01jmxt844 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I80281795 |
| authorships[3].institutions[0].country_code | NZ |
| authorships[3].institutions[0].display_name | University of Otago |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Wickliffe C. Abraham |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | University of Otago |
| authorships[4].author.id | https://openalex.org/A5041971539 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-1116-3839 |
| authorships[4].author.display_name | Tim Anderson |
| authorships[4].countries | NZ |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I80281795 |
| authorships[4].affiliations[0].raw_affiliation_string | University of Otago |
| authorships[4].institutions[0].id | https://openalex.org/I80281795 |
| authorships[4].institutions[0].ror | https://ror.org/01jmxt844 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I80281795 |
| authorships[4].institutions[0].country_code | NZ |
| authorships[4].institutions[0].display_name | University of Otago |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Tim J. Anderson |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | University of Otago |
| authorships[5].author.id | https://openalex.org/A5108888880 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Nick Cutfield |
| authorships[5].countries | NZ |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I80281795 |
| authorships[5].affiliations[0].raw_affiliation_string | University of Otago |
| authorships[5].institutions[0].id | https://openalex.org/I80281795 |
| authorships[5].institutions[0].ror | https://ror.org/01jmxt844 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I80281795 |
| authorships[5].institutions[0].country_code | NZ |
| authorships[5].institutions[0].display_name | University of Otago |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Nick Cutfield |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | University of Otago |
| authorships[6].author.id | https://openalex.org/A5000426386 |
| authorships[6].author.orcid | https://orcid.org/0000-0001-8568-3426 |
| authorships[6].author.display_name | Sean Hogan |
| authorships[6].countries | NZ |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I80281795 |
| authorships[6].affiliations[0].raw_affiliation_string | University of Otago |
| authorships[6].institutions[0].id | https://openalex.org/I80281795 |
| authorships[6].institutions[0].ror | https://ror.org/01jmxt844 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I80281795 |
| authorships[6].institutions[0].country_code | NZ |
| authorships[6].institutions[0].display_name | University of Otago |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Sean Hogan |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | University of Otago |
| authorships[7].author.id | https://openalex.org/A5046268246 |
| authorships[7].author.orcid | https://orcid.org/0000-0001-7343-916X |
| authorships[7].author.display_name | David Ireland |
| authorships[7].countries | NZ |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I80281795 |
| authorships[7].affiliations[0].raw_affiliation_string | University of Otago |
| authorships[7].institutions[0].id | https://openalex.org/I80281795 |
| authorships[7].institutions[0].ror | https://ror.org/01jmxt844 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I80281795 |
| authorships[7].institutions[0].country_code | NZ |
| authorships[7].institutions[0].display_name | University of Otago |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | David Ireland |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | University of Otago |
| authorships[8].author.id | https://openalex.org/A5001680547 |
| authorships[8].author.orcid | https://orcid.org/0000-0003-0621-212X |
| authorships[8].author.display_name | Tracy R. Melzer |
| authorships[8].countries | NZ |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I4210151947 |
| authorships[8].affiliations[0].raw_affiliation_string | Brain Research New Zealand |
| authorships[8].institutions[0].id | https://openalex.org/I4210151947 |
| authorships[8].institutions[0].ror | https://ror.org/04m9wnx11 |
| authorships[8].institutions[0].type | facility |
| authorships[8].institutions[0].lineage | https://openalex.org/I4210151947 |
| authorships[8].institutions[0].country_code | NZ |
| authorships[8].institutions[0].display_name | Brain Research New Zealand |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Tracy R. Melzer |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Brain Research New Zealand |
| authorships[9].author.id | https://openalex.org/A5006636964 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-0383-9886 |
| authorships[9].author.display_name | Sandhya Ramrakha |
| authorships[9].countries | NZ |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I80281795 |
| authorships[9].affiliations[0].raw_affiliation_string | University of Otago |
| authorships[9].institutions[0].id | https://openalex.org/I80281795 |
| authorships[9].institutions[0].ror | https://ror.org/01jmxt844 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I80281795 |
| authorships[9].institutions[0].country_code | NZ |
| authorships[9].institutions[0].display_name | University of Otago |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Sandhya Ramrakha |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | University of Otago |
| authorships[10].author.id | https://openalex.org/A5083095072 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-4076-5927 |
| authorships[10].author.display_name | Karen Sugden |
| authorships[10].countries | US |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I170897317 |
| authorships[10].affiliations[0].raw_affiliation_string | Duke University |
| authorships[10].institutions[0].id | https://openalex.org/I170897317 |
| authorships[10].institutions[0].ror | https://ror.org/00py81415 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I170897317 |
| authorships[10].institutions[0].country_code | US |
| authorships[10].institutions[0].display_name | Duke University |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Karen Sugden |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Duke University |
| authorships[11].author.id | https://openalex.org/A5060168011 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-1057-9859 |
| authorships[11].author.display_name | Reremoana Theodore |
| authorships[11].countries | NZ |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I80281795 |
| authorships[11].affiliations[0].raw_affiliation_string | University of Otago |
| authorships[11].institutions[0].id | https://openalex.org/I80281795 |
| authorships[11].institutions[0].ror | https://ror.org/01jmxt844 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I80281795 |
| authorships[11].institutions[0].country_code | NZ |
| authorships[11].institutions[0].display_name | University of Otago |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Reremoana Theodore |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | University of Otago |
| authorships[12].author.id | https://openalex.org/A5030654040 |
| authorships[12].author.orcid | https://orcid.org/0000-0003-3274-5317 |
| authorships[12].author.display_name | Benjamin Williams |
| authorships[12].countries | US |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I170897317 |
| authorships[12].affiliations[0].raw_affiliation_string | Duke University |
| authorships[12].institutions[0].id | https://openalex.org/I170897317 |
| authorships[12].institutions[0].ror | https://ror.org/00py81415 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I170897317 |
| authorships[12].institutions[0].country_code | US |
| authorships[12].institutions[0].display_name | Duke University |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Benjamin S. Williams |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Duke University |
| authorships[13].author.id | https://openalex.org/A5026594853 |
| authorships[13].author.orcid | https://orcid.org/0000-0003-0082-4600 |
| authorships[13].author.display_name | Avshalom Caspi |
| authorships[13].countries | US |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I170897317 |
| authorships[13].affiliations[0].raw_affiliation_string | Duke University |
| authorships[13].institutions[0].id | https://openalex.org/I170897317 |
| authorships[13].institutions[0].ror | https://ror.org/00py81415 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I170897317 |
| authorships[13].institutions[0].country_code | US |
| authorships[13].institutions[0].display_name | Duke University |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Avshalom Caspi |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Duke University |
| authorships[14].author.id | https://openalex.org/A5081542021 |
| authorships[14].author.orcid | https://orcid.org/0000-0002-8589-6760 |
| authorships[14].author.display_name | Terrie E. Moffitt |
| authorships[14].countries | US |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I170897317 |
| authorships[14].affiliations[0].raw_affiliation_string | Duke University |
| authorships[14].institutions[0].id | https://openalex.org/I170897317 |
| authorships[14].institutions[0].ror | https://ror.org/00py81415 |
| authorships[14].institutions[0].type | education |
| authorships[14].institutions[0].lineage | https://openalex.org/I170897317 |
| authorships[14].institutions[0].country_code | US |
| authorships[14].institutions[0].display_name | Duke University |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Terrie E. Moffitt |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Duke University |
| authorships[15].author.id | https://openalex.org/A5062228109 |
| authorships[15].author.orcid | https://orcid.org/0000-0003-3052-9880 |
| authorships[15].author.display_name | Ahmad R. Hariri |
| authorships[15].countries | US |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I170897317 |
| authorships[15].affiliations[0].raw_affiliation_string | Duke University |
| authorships[15].institutions[0].id | https://openalex.org/I170897317 |
| authorships[15].institutions[0].ror | https://ror.org/00py81415 |
| authorships[15].institutions[0].type | education |
| authorships[15].institutions[0].lineage | https://openalex.org/I170897317 |
| authorships[15].institutions[0].country_code | US |
| authorships[15].institutions[0].display_name | Duke University |
| authorships[15].author_position | last |
| authorships[15].raw_author_name | Ahmad R. Hariri |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Duke University |
| has_content.pdf | True |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.biorxiv.org/content/biorxiv/early/2024/08/22/2024.08.19.608305.full.pdf |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | An estimate of the longitudinal pace of aging from a single brain scan predicts dementia conversion, morbidity, and mortality |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10009 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998000264167786 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2738 |
| primary_topic.subfield.display_name | Psychiatry and Mental health |
| primary_topic.display_name | Dementia and Cognitive Impairment Research |
| related_works | https://openalex.org/W4210634400, https://openalex.org/W4385442515, https://openalex.org/W4389935977, https://openalex.org/W3121529995, https://openalex.org/W4401403960, https://openalex.org/W2089788984, https://openalex.org/W2905614390, https://openalex.org/W4388233941, https://openalex.org/W4306641746, https://openalex.org/W2012437345 |
| cited_by_count | 1 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| locations_count | 3 |
| best_oa_location.id | doi:10.1101/2024.08.19.608305 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306402567 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| best_oa_location.source.host_organization | https://openalex.org/I2750212522 |
| best_oa_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| best_oa_location.license | cc-by-nc-nd |
| best_oa_location.pdf_url | https://www.biorxiv.org/content/biorxiv/early/2024/08/22/2024.08.19.608305.full.pdf |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.1101/2024.08.19.608305 |
| primary_location.id | doi:10.1101/2024.08.19.608305 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4306402567 |
| primary_location.source.issn | |
| primary_location.source.type | repository |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| primary_location.source.host_organization | https://openalex.org/I2750212522 |
| primary_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| primary_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| primary_location.license | cc-by-nc-nd |
| primary_location.pdf_url | https://www.biorxiv.org/content/biorxiv/early/2024/08/22/2024.08.19.608305.full.pdf |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.1101/2024.08.19.608305 |
| publication_date | 2024-08-22 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W2201939452, https://openalex.org/W3136411224, https://openalex.org/W4285728814, https://openalex.org/W4386334003, https://openalex.org/W4391821966, https://openalex.org/W3033799168, https://openalex.org/W4386070219, https://openalex.org/W4366998144, https://openalex.org/W2796559433, https://openalex.org/W4283016888, https://openalex.org/W2121091193, https://openalex.org/W1974047233, https://openalex.org/W2969410982, https://openalex.org/W4226334010, https://openalex.org/W2912654909, https://openalex.org/W2949100461, https://openalex.org/W4384827929, https://openalex.org/W3049650820, https://openalex.org/W4294926340, https://openalex.org/W4205358347, https://openalex.org/W4391179489, https://openalex.org/W2231692891, https://openalex.org/W4284896104, https://openalex.org/W4321440558, https://openalex.org/W4393220664, https://openalex.org/W4393317677, https://openalex.org/W2579617530, https://openalex.org/W3037286432, https://openalex.org/W4313528065, https://openalex.org/W1586793705, https://openalex.org/W4392091326, https://openalex.org/W3024838586, https://openalex.org/W4392595045, https://openalex.org/W3161192540, https://openalex.org/W3203395588, https://openalex.org/W4313547904, https://openalex.org/W4293660326, https://openalex.org/W4388489412, https://openalex.org/W4241074797, https://openalex.org/W3022131036, https://openalex.org/W2011402106, https://openalex.org/W2402186437, https://openalex.org/W2165745297, https://openalex.org/W2094788831, https://openalex.org/W2976878096, https://openalex.org/W2103069600, https://openalex.org/W2035079822, https://openalex.org/W4226153286, https://openalex.org/W2125043543, https://openalex.org/W2101487986, https://openalex.org/W2024729467, https://openalex.org/W4396673676, https://openalex.org/W2044367669, https://openalex.org/W4365517131, https://openalex.org/W2164059021, https://openalex.org/W1996823741, https://openalex.org/W4392267148, https://openalex.org/W3171528151, https://openalex.org/W2104018747, https://openalex.org/W4293004881, https://openalex.org/W4388869973, https://openalex.org/W4401894695, https://openalex.org/W3011699797, https://openalex.org/W3010089023, https://openalex.org/W4389506161, https://openalex.org/W4387661692, https://openalex.org/W2952009394, https://openalex.org/W4400957403, https://openalex.org/W4295419447, https://openalex.org/W4391283249, https://openalex.org/W2118518216, https://openalex.org/W4377042713, https://openalex.org/W2782702904, https://openalex.org/W2036162736, https://openalex.org/W2044161093, https://openalex.org/W3035022781, https://openalex.org/W4403799239, https://openalex.org/W2988912149, https://openalex.org/W4380291883, https://openalex.org/W3105091572, https://openalex.org/W4308625500, https://openalex.org/W3046275966, https://openalex.org/W2422981416, https://openalex.org/W2958408897, https://openalex.org/W3002500652, https://openalex.org/W2154116121, https://openalex.org/W2040757738, https://openalex.org/W2054134869, https://openalex.org/W2979450655, https://openalex.org/W1991881145, https://openalex.org/W2029932732, https://openalex.org/W2913673442, https://openalex.org/W1983208069, https://openalex.org/W4386624665, https://openalex.org/W2078524519, https://openalex.org/W1953027527, https://openalex.org/W2024719735, https://openalex.org/W1847168837, https://openalex.org/W2165758561, https://openalex.org/W2085870059, https://openalex.org/W2082704080, https://openalex.org/W2607804943, https://openalex.org/W2139886607, https://openalex.org/W2110208125, https://openalex.org/W2105991991, https://openalex.org/W2103481737, https://openalex.org/W3016980863, https://openalex.org/W2950392934, https://openalex.org/W3105778666, https://openalex.org/W2101135654, https://openalex.org/W3033423750, https://openalex.org/W2602552939, https://openalex.org/W2141403362, https://openalex.org/W3038220767, https://openalex.org/W2126104386, https://openalex.org/W4226486832, https://openalex.org/W4234180827, https://openalex.org/W3135284049, https://openalex.org/W4205380741, https://openalex.org/W4386070353, https://openalex.org/W2959062720, https://openalex.org/W2020044743, https://openalex.org/W2148080316, https://openalex.org/W4391440477, https://openalex.org/W2789983651, https://openalex.org/W2167311298, https://openalex.org/W4318269905, https://openalex.org/W2058161128, https://openalex.org/W2008854521, https://openalex.org/W4200448923 |
| referenced_works_count | 130 |
| abstract_inverted_index.a | 24, 158, 189 |
| abstract_inverted_index.To | 1 |
| abstract_inverted_index.UK | 85 |
| abstract_inverted_index.an | 49, 134, 172 |
| abstract_inverted_index.be | 196 |
| abstract_inverted_index.in | 128, 156 |
| abstract_inverted_index.is | 13, 26, 188 |
| abstract_inverted_index.it | 12 |
| abstract_inverted_index.of | 21, 57, 68, 110, 141, 160, 213 |
| abstract_inverted_index.or | 73, 180 |
| abstract_inverted_index.to | 15, 78, 101, 168, 184, 200, 204 |
| abstract_inverted_index.we | 47 |
| abstract_inverted_index.DNA | 34 |
| abstract_inverted_index.MRI | 174, 192 |
| abstract_inverted_index.age | 170 |
| abstract_inverted_index.and | 8, 18, 51, 84, 99, 113, 126, 151, 209, 216 |
| abstract_inverted_index.but | 32 |
| abstract_inverted_index.for | 54 |
| abstract_inverted_index.how | 3, 22 |
| abstract_inverted_index.the | 44, 55, 65, 79, 111, 201, 211 |
| abstract_inverted_index.was | 178 |
| abstract_inverted_index.MRI: | 64 |
| abstract_inverted_index.Pace | 67 |
| abstract_inverted_index.When | 166 |
| abstract_inverted_index.also | 117 |
| abstract_inverted_index.body | 112 |
| abstract_inverted_index.data | 42 |
| abstract_inverted_index.fast | 23 |
| abstract_inverted_index.from | 43, 61, 71 |
| abstract_inverted_index.gap, | 171 |
| abstract_inverted_index.help | 205 |
| abstract_inverted_index.made | 197 |
| abstract_inverted_index.many | 38 |
| abstract_inverted_index.more | 181 |
| abstract_inverted_index.poor | 121 |
| abstract_inverted_index.rate | 56 |
| abstract_inverted_index.that | 89, 194 |
| abstract_inverted_index.this | 76 |
| abstract_inverted_index.were | 154 |
| abstract_inverted_index.will | 195 |
| abstract_inverted_index.with | 139, 164 |
| abstract_inverted_index.Aging | 69 |
| abstract_inverted_index.Latin | 161 |
| abstract_inverted_index.Using | 41 |
| abstract_inverted_index.aging | 4, 31, 59, 109, 175, 207 |
| abstract_inverted_index.brain | 63, 97, 169 |
| abstract_inverted_index.close | 105 |
| abstract_inverted_index.data, | 36 |
| abstract_inverted_index.lack. | 40 |
| abstract_inverted_index.links | 106 |
| abstract_inverted_index.lower | 142 |
| abstract_inverted_index.older | 129 |
| abstract_inverted_index.risk, | 11 |
| abstract_inverted_index.which | 37 |
| abstract_inverted_index.Study, | 46 |
| abstract_inverted_index.aging. | 27 |
| abstract_inverted_index.brain, | 114 |
| abstract_inverted_index.clocks | 29 |
| abstract_inverted_index.faster | 90, 115, 146 |
| abstract_inverted_index.future | 123 |
| abstract_inverted_index.health | 137 |
| abstract_inverted_index.people | 140 |
| abstract_inverted_index.person | 25 |
| abstract_inverted_index.sample | 159 |
| abstract_inverted_index.status | 144 |
| abstract_inverted_index.Biobank | 86 |
| abstract_inverted_index.Disease | 81 |
| abstract_inverted_index.Dunedin | 45, 66 |
| abstract_inverted_index.adults. | 130 |
| abstract_inverted_index.affects | 5 |
| abstract_inverted_index.between | 107, 149 |
| abstract_inverted_index.chronic | 124 |
| abstract_inverted_index.decline | 7 |
| abstract_inverted_index.derived | 60 |
| abstract_inverted_index.develop | 16 |
| abstract_inverted_index.disease | 10 |
| abstract_inverted_index.health, | 122 |
| abstract_inverted_index.measure | 30, 53, 77, 193 |
| abstract_inverted_index.related | 183 |
| abstract_inverted_index.require | 33 |
| abstract_inverted_index.showing | 145 |
| abstract_inverted_index.studies | 39 |
| abstract_inverted_index.“next | 190 |
| abstract_inverted_index.ABSTRACT | 0 |
| abstract_inverted_index.American | 162 |
| abstract_inverted_index.accurate | 17, 50 |
| abstract_inverted_index.atrophy, | 98 |
| abstract_inverted_index.clinical | 185 |
| abstract_inverted_index.compared | 167 |
| abstract_inverted_index.datasets | 87 |
| abstract_inverted_index.dementia | 214 |
| abstract_inverted_index.evaluate | 210 |
| abstract_inverted_index.existing | 173 |
| abstract_inverted_index.followed | 133 |
| abstract_inverted_index.frailty, | 120 |
| abstract_inverted_index.gradient | 138 |
| abstract_inverted_index.measures | 20 |
| abstract_inverted_index.patients | 163 |
| abstract_inverted_index.physical | 119 |
| abstract_inverted_index.publicly | 198 |
| abstract_inverted_index.reliable | 19, 52 |
| abstract_inverted_index.research | 202, 208 |
| abstract_inverted_index.revealed | 88 |
| abstract_inverted_index.strongly | 182 |
| abstract_inverted_index.BrainLat, | 157 |
| abstract_inverted_index.Exporting | 75 |
| abstract_inverted_index.available | 199 |
| abstract_inverted_index.cognitive | 94, 152 |
| abstract_inverted_index.community | 203 |
| abstract_inverted_index.dementia. | 103, 165 |
| abstract_inverted_index.diagnosed | 102 |
| abstract_inverted_index.diseases, | 125 |
| abstract_inverted_index.increases | 9 |
| abstract_inverted_index.introduce | 48 |
| abstract_inverted_index.mortality | 127 |
| abstract_inverted_index.necessary | 14 |
| abstract_inverted_index.outcomes. | 186 |
| abstract_inverted_index.predicted | 92, 118 |
| abstract_inverted_index.similarly | 179 |
| abstract_inverted_index.Calculated | 70 |
| abstract_inverted_index.Epigenetic | 28 |
| abstract_inverted_index.Initiative | 83 |
| abstract_inverted_index.accelerate | 206 |
| abstract_inverted_index.anti-aging | 217 |
| abstract_inverted_index.biomarker, | 176 |
| abstract_inverted_index.conversion | 100 |
| abstract_inverted_index.functional | 6 |
| abstract_inverted_index.impairment | 153 |
| abstract_inverted_index.prevention | 215 |
| abstract_inverted_index.replicated | 155 |
| abstract_inverted_index.understand | 2 |
| abstract_inverted_index.accelerated | 96 |
| abstract_inverted_index.established | 135 |
| abstract_inverted_index.impairment, | 95 |
| abstract_inverted_index.methylation | 35 |
| abstract_inverted_index.strategies. | 218 |
| abstract_inverted_index.Associations | 148 |
| abstract_inverted_index.DunedinPACNI | 91, 116, 132, 150, 177, 187 |
| abstract_inverted_index.Furthermore, | 131 |
| abstract_inverted_index.NeuroImaging | 72 |
| abstract_inverted_index.Neuroimaging | 82 |
| abstract_inverted_index.Underscoring | 104 |
| abstract_inverted_index.longitudinal | 58, 108 |
| abstract_inverted_index.Alzheimer’s | 80 |
| abstract_inverted_index.DunedinPACNI. | 74, 147 |
| abstract_inverted_index.effectiveness | 212 |
| abstract_inverted_index.generation” | 191 |
| abstract_inverted_index.socioeconomic | 136, 143 |
| abstract_inverted_index.cross-sectional | 62 |
| abstract_inverted_index.participants’ | 93 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| corresponding_author_ids | https://openalex.org/A5027144504 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 16 |
| corresponding_institution_ids | https://openalex.org/I170897317 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6299999952316284 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.67747731 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |