An evidence-based debate on epigenetics and immunosenescence in COVID-19 Article Swipe
Claudio Napoli
,
Enrico Coscioni
,
Ugo Trama
,
Maria Grazia Strozziero
,
Giuditta Benincasa
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.crimmu.2023.100069
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.crimmu.2023.100069
Immunosenescence contributes to the decline of immune function leading to a reduced ability to respond to severe coronavirus disease 2019 (COVID-19) in elderly patients. Clinical course of COVID-19 is widely heterogeneous and guided by the possible interplay between genetic background and epigenetic-sensitive mechanisms underlying the immunosenescence which could explain, at least in part, the higher percentage of disease severity in elderly individuals. The most convincing evidence regards the hypomethylation of the angiotensin-converting enzyme 2 (ACE2) promoter gene in lungs as well as the citrullination of histone H3 in neutrophils which have been associated with worsening of COVID-19 outcome in elderly patients. In contrast, centenarians who have showed milder symptoms have been associated to a younger "epigenetic age" based on DNA methylation profiles at specific genomic sites (epigenetic clock). Some large prospective studies showed that the acceleration of epigenetic aging as well as the shortening of telomeres were significantly associated with lymphopenia and poor outcome suggesting prognostic biomarkers in elderly COVID-19 patients. Furthermore, randomized clinical trials showed that statins, L-arginine, and resveratrol could mediate anti-inflammatory effects via indirect epigenetic interference and might improve COVID-19 outcome. Here, we discuss the epigenetic-sensitive events which might contribute to increase the risk of severity and mortality in older subjects and possible targeted therapies to counteract immunosenescence.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.crimmu.2023.100069
- OA Status
- gold
- Cited By
- 9
- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W4387068781Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.crimmu.2023.100069Digital Object Identifier
- Title
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An evidence-based debate on epigenetics and immunosenescence in COVID-19Work title
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reviewOpenAlex work type
- Language
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enPrimary language
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2023Year of publication
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2023-01-01Full publication date if available
- Authors
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Claudio Napoli, Enrico Coscioni, Ugo Trama, Maria Grazia Strozziero, Giuditta BenincasaList of authors in order
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https://doi.org/10.1016/j.crimmu.2023.100069Publisher landing page
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.crimmu.2023.100069Direct OA link when available
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Immunosenescence, Epigenetics, DNA methylation, Telomere, Disease, Biology, Medicine, Bioinformatics, Immunology, Internal medicine, Genetics, Immune system, Gene, Gene expressionTop concepts (fields/topics) attached by OpenAlex
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9Total citation count in OpenAlex
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2025: 4, 2024: 5Per-year citation counts (last 5 years)
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