Annals of Clinical and Translational Neurology • Vol 7 • No 2
An expanded parenchymal CD8+ T cell clone in GABA<sub>A</sub> receptor encephalitis
January 2020 • Aline Bracher, Carmen Alcalá, Jaime Ferrer-Lozano, Nico Melzer, Reinhard Hohlfeld, Bonaventura Casanova, Eduardo Beltrán, Klaus Dornmair
Abstract The role of T cells in autoimmune encephalitis syndromes with autoantibodies against cell surface antigens is still enigmatic. Here we analyzed the T cell receptor repertoires of CD8+ and CD4+ T cells in a patient with “idiopathic” gamma‐aminobutyric‐acid‐A receptor (GABA A ‐R) encephalitis by next‐generation sequencing and single‐cell analyses. We identified a CD8+ T cell clone that was strongly expanded in the cerebrospinal fluid and in the hippocampus but not in the operculo‐insular cortex. By contrast…