An Experimental Model of Myocardial Infarction for Studying Cardiac Repair and Remodeling in Knockout Mice Article Swipe
Florencia S. Fontana Estevez
,
Verónica Miksztowicz
,
Ignacio M. Seropián
,
Pablo Cassaglia
,
R. V. Ibáñez Bustos
,
Vanessa Touceda
,
Tomás F. Cianciulli
,
Verónica Cassanova
,
Celina Morales
,
Germán E. Gónzalez
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3791/64143
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3791/64143
Cardiovascular disease is the most prevalent cause of death in Western countries, with acute myocardial infarction (MI) being the most prevalent form. This paper describes a protocol for studying the role of galectin 3 (Gal-3) in the temporal evolution of cardiac healing and remodeling in an experimental animal model of MI. The procedures described include an experimental model of MI with a permanent coronary ligature in male C57BL/6J (control) and Gal-3 knockout (KO) mice, an echocardiography procedure to study cardiac remodeling and systolic function in vivo, a histological evaluation of interstitial myocardial fibrosis with picrosirius red-stained and rhodamine-conjugated lectin-stained sections for studying myocyte hypertrophy by the cross-sectional area (MCSA), and the quantification of infarct size and cardiac remodeling (scar thinning, septum thickness, and expansion index) by planimetry in slices stained with Masson's trichrome and triphenyl tetrazolium chloride. Gal-3 KO mice with MI showed disrupted cardiac remodeling and an increase in the scar thinning ratio and the expansion index. At the onset of MI, myocardial function and cardiac remodeling were also severely affected. At 4 weeks post MI, the natural evolution of fibrosis in infarcted Gal-3 KO mice was also affected. In summary, the experimental model of MI is a suitable model for studying the temporal evolution of cardiac repair and remodeling in mice with the genetic deletion of Gal-3 and other animal models. The lack of Gal-3 affects the dynamics of cardiac repair and disrupts the evolution of cardiac remodeling and function after MI.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3791/64143
- https://www.jove.com/pdf/64143/an-experimental-model-myocardial-infarction-for-studying-cardiac
- OA Status
- bronze
- Cited By
- 3
- References
- 18
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4384296307
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4384296307Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3791/64143Digital Object Identifier
- Title
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An Experimental Model of Myocardial Infarction for Studying Cardiac Repair and Remodeling in Knockout MiceWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-07-14Full publication date if available
- Authors
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Florencia S. Fontana Estevez, Verónica Miksztowicz, Ignacio M. Seropián, Pablo Cassaglia, R. V. Ibáñez Bustos, Vanessa Touceda, Tomás F. Cianciulli, Verónica Cassanova, Celina Morales, Germán E. GónzalezList of authors in order
- Landing page
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https://doi.org/10.3791/64143Publisher landing page
- PDF URL
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https://www.jove.com/pdf/64143/an-experimental-model-myocardial-infarction-for-studying-cardiacDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
- OA URL
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https://www.jove.com/pdf/64143/an-experimental-model-myocardial-infarction-for-studying-cardiacDirect OA link when available
- Concepts
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Medicine, Myocardial infarction, Cardiac function curve, Ventricular remodeling, Cardiology, Internal medicine, Fibrosis, Cardiac fibrosis, Masson's trichrome stain, Pathology, Heart failureTop concepts (fields/topics) attached by OpenAlex
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3Total citation count in OpenAlex
- Citations by year (recent)
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2024: 2, 2023: 1Per-year citation counts (last 5 years)
- References (count)
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18Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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