An immunogenetic view of COVID-19 Article Swipe
Vitor R. C. Aguiar
,
Danillo G. Augusto
,
Erick C. Castelli
,
Jill A. Hollenbach
,
Diogo Meyer
,
Kelly Nunes
,
Maria Luiza Petzl‐Erler
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.6084/m9.figshare.16494314
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.6084/m9.figshare.16494314
Meeting the challenges brought by the COVID-19 pandemic requires an interdisciplinary approach. In this context, integrating knowledge of immune function with an understanding of how genetic variation influences the nature of immunity is a key challenge. Immunogenetics can help explain the heterogeneity of susceptibility and protection to the viral infection and disease progression. Here, we review the knowledge developed so far, discussing fundamental genes for triggering the innate and adaptive immune responses associated with a viral infection, especially with the SARS-CoV-2 mechanisms. We emphasize the role of the HLA and KIR genes, discussing what has been uncovered about their role in COVID-19 and addressing methodological challenges of studying these genes. Finally, we comment on questions that arise when studying admixed populations, highlighting the case of Brazil. We argue that the interplay between immunology and an understanding of genetic associations can provide an important contribution to our knowledge of COVID-19.
Related Topics
Concepts
Coronavirus disease 2019 (COVID-19)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
2019-20 coronavirus outbreak
Virology
Biology
Geography
Medicine
Outbreak
Infectious disease (medical specialty)
Disease
Pathology
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- https://doi.org/10.6084/m9.figshare.16494314
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An immunogenetic view of COVID-19Work title
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2021Year of publication
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2021-01-01Full publication date if available
- Authors
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Vitor R. C. Aguiar, Danillo G. Augusto, Erick C. Castelli, Jill A. Hollenbach, Diogo Meyer, Kelly Nunes, Maria Luiza Petzl‐ErlerList of authors in order
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https://doi.org/10.6084/m9.figshare.16494314Publisher landing page
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goldOpen access status per OpenAlex
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https://doi.org/10.6084/m9.figshare.16494314Direct OA link when available
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Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), 2019-20 coronavirus outbreak, Virology, Biology, Geography, Medicine, Outbreak, Infectious disease (medical specialty), Disease, PathologyTop concepts (fields/topics) attached by OpenAlex
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