An Integrated NMR, LC-DAD-MS, LC-QTOF Metabolomic Characterization of Sartoria hedysaroides: Correlation of Antioxidant and Enzyme Inhibitory Activity with Chemical Composition by Multivariate Data Analysis Article Swipe
Stefano Dall’Acqua
,
Stefania Sut
,
Kouadio Ibrahime Sinan
,
Gökhan Zengin
,
Irene Ferrarese
,
Gregorio Peron
,
Evren Yıldıztugay
,
Marie Carene Nancy Picot-Allain
,
Mohamad Fawzi Mahomoodally
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/antiox11010110
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/antiox11010110
Sartoria hedysaroides Boiss and Heldr. (Fabaceae) is an endemic plant of Turkey that has received little scientific consideration so far. In the present study, the chemical profiles of extracts from the aerial part and roots of S. hedysaroides obtained using solvents with different polarities were analyzed combining integrated NMR, LC-DAD-MSn, and LC-QTOF methods. In vitro antioxidant and enzyme inhibitory activities were evaluated, and the results were combined with chemical data using multivariate approaches. Phenolic acids, flavonoids, ellagitannins, and coumarins were identified and quantified in the extracts of aerial part and roots. Methanolic extract of S. hedysaroides aerial part showed the highest phenolic content and the highest antioxidant activity and cupric ion reducing antioxidant capacity. Dichloromethane extract of S. hedysaroides roots showed the highest inhibition of butyryl cholinesterase, while methanolic extract of S. hedysaroides aerial part was the most active tyrosinase inhibitor. Multivariate data analysis allowed us to observe a good correlation between phenolic compounds, especially caffeoylquinic derivatives and flavonoids and the antioxidant activity of extracts. Acetylcholinesterase inhibition was correlated with the presence of caffeoylquinic acids and coumarins. Overall, the present study appraised the biological potential of understudied S. hedysaroides, and provided a comprehensive approach combining metabolomic characterization of plant material and multivariate data analysis for the correlation of chemical data with results from multi-target biological assays.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/antiox11010110
- https://www.mdpi.com/2076-3921/11/1/110/pdf?version=1641286311
- OA Status
- gold
- Cited By
- 4
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4205088900
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- OpenAlex ID
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https://openalex.org/W4205088900Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/antiox11010110Digital Object Identifier
- Title
-
An Integrated NMR, LC-DAD-MS, LC-QTOF Metabolomic Characterization of Sartoria hedysaroides: Correlation of Antioxidant and Enzyme Inhibitory Activity with Chemical Composition by Multivariate Data AnalysisWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
-
2022-01-04Full publication date if available
- Authors
-
Stefano Dall’Acqua, Stefania Sut, Kouadio Ibrahime Sinan, Gökhan Zengin, Irene Ferrarese, Gregorio Peron, Evren Yıldıztugay, Marie Carene Nancy Picot-Allain, Mohamad Fawzi MahomoodallyList of authors in order
- Landing page
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https://doi.org/10.3390/antiox11010110Publisher landing page
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https://www.mdpi.com/2076-3921/11/1/110/pdf?version=1641286311Direct link to full text PDF
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2076-3921/11/1/110/pdf?version=1641286311Direct OA link when available
- Concepts
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Chemistry, Antioxidant, Fabaceae, Metabolomics, Traditional medicine, Chromatography, Biochemistry, Botany, Biology, MedicineTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 1, 2023: 2Per-year citation counts (last 5 years)
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41Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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