An overview of the current evidences on the role of iron in colorectal cancer: a review Article Swipe
Mohammad Hasan Yousefi
,
Alireza Masoudi
,
Masoumeh Saberi Rounkian
,
Maryam Mansouri
,
B Bahjeri Hojat
,
Marzieh Kaveh Samani
,
Razieh Veisi
,
Parisa Honarvar Bakeshloo
,
Reza Nosratipour
,
Hamed Afkhami
,
Sepideh Saeb
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fonc.2025.1499094
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fonc.2025.1499094
Colorectal cancer (CRC) is a common and lethal malignancy that affects millions of people worldwide. Iron is an essential micronutrient that plays a vital role in various biological processes, but also has pro-oxidant and pro-inflammatory effects that may contribute to carcinogenesis. The relationship between iron and CRC is complex and influenced by multiple factors, such as dietary intake, absorption, storage, metabolism, and excretion of iron, as well as genetic and environmental factors that modulate iron homeostasis. This review article aims to provide an overview of the current evidences on the role of iron in CRC, discussing the potential mechanisms by which iron may affect CRC development and progression, as well as the implications for prevention and treatment. This review tries to focus on the following aspects: an introduction to iron and its role in CRC, role of heme and non-heme iron in CRC, dietary patterns, nutrition, and CRC, iron overload in CRC, iron deficiency and its role in CRC especially in surgery outcome and iron therapy and blood transfusion in CRC.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fonc.2025.1499094
- https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1499094/pdf
- OA Status
- gold
- Cited By
- 3
- References
- 119
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4407898921
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4407898921Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fonc.2025.1499094Digital Object Identifier
- Title
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An overview of the current evidences on the role of iron in colorectal cancer: a reviewWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-02-24Full publication date if available
- Authors
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Mohammad Hasan Yousefi, Alireza Masoudi, Masoumeh Saberi Rounkian, Maryam Mansouri, B Bahjeri Hojat, Marzieh Kaveh Samani, Razieh Veisi, Parisa Honarvar Bakeshloo, Reza Nosratipour, Hamed Afkhami, Sepideh SaebList of authors in order
- Landing page
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https://doi.org/10.3389/fonc.2025.1499094Publisher landing page
- PDF URL
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https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1499094/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1499094/pdfDirect OA link when available
- Concepts
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Colorectal cancer, Medicine, Cancer, Iron deficiency, Micronutrient, Carcinogenesis, Malignancy, Bioinformatics, Physiology, Anemia, Cancer research, Internal medicine, Biology, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
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2025: 3Per-year citation counts (last 5 years)
- References (count)
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119Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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