An RNA-based system to study hepatitis B virus replication and select drug-resistance mutations Article Swipe
Yingpu Yu
,
William M. Schneider
,
Eleftherios Michailidis
,
Ashley Acevedo
,
Yi Ni
,
Pradeep M. Ambrose
,
C. M. Zou
,
Mohammad Kabbani
,
Corrine Quirk
,
Cyprien Jahan
,
Xianfang Wu
,
Stephan Urban
,
Amir Shlomai
,
Ype P. de Jong
,
Charles M. Rice
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1101/787630
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1101/787630
Hepatitis B virus (HBV) chronically infects over 250 million people worldwide, increasing their risk of liver cirrhosis and hepatocellular carcinoma. There is a vaccine to prevent new infections, but no efficient cure for chronic infection. New insights into HBV biology are needed to improve cure rates for this widespread devastating disease. We describe a method to initiate replication of HBV, a DNA virus, using synthetic RNA. This approach has several advantages over existing systems: it eliminates contaminating background signal from input virus or plasmid DNA and can be easily adapted to multiple genotypes and mutants. Further, it can be applied to identify anti-HBV compounds, measure anti-HBV drug efficiency, study virus evolution, and, as we demonstrate, it can be uniquely applied to predict antiviral drug resistance.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/787630
- https://www.biorxiv.org/content/biorxiv/early/2019/10/02/787630.full.pdf
- OA Status
- green
- Cited By
- 4
- References
- 20
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2978455960
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2978455960Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/787630Digital Object Identifier
- Title
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An RNA-based system to study hepatitis B virus replication and select drug-resistance mutationsWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2019Year of publication
- Publication date
-
2019-10-02Full publication date if available
- Authors
-
Yingpu Yu, William M. Schneider, Eleftherios Michailidis, Ashley Acevedo, Yi Ni, Pradeep M. Ambrose, C. M. Zou, Mohammad Kabbani, Corrine Quirk, Cyprien Jahan, Xianfang Wu, Stephan Urban, Amir Shlomai, Ype P. de Jong, Charles M. RiceList of authors in order
- Landing page
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https://doi.org/10.1101/787630Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2019/10/02/787630.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2019/10/02/787630.full.pdfDirect OA link when available
- Concepts
-
Hepatitis B virus, Virology, Hepatocellular carcinoma, Virus, Drug resistance, Antiviral drug, Cirrhosis, Viral replication, RNA virus, Biology, RNA, Medicine, Gene, Cancer research, Genetics, GastroenterologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
-
2023: 1, 2022: 2, 2021: 1Per-year citation counts (last 5 years)
- References (count)
-
20Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.million | 9 |
| abstract_inverted_index.plasmid | 84 |
| abstract_inverted_index.predict | 122 |
| abstract_inverted_index.prevent | 26 |
| abstract_inverted_index.several | 70 |
| abstract_inverted_index.vaccine | 24 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Further, | 96 |
| abstract_inverted_index.anti-HBV | 103, 106 |
| abstract_inverted_index.approach | 68 |
| abstract_inverted_index.describe | 53 |
| abstract_inverted_index.disease. | 51 |
| abstract_inverted_index.existing | 73 |
| abstract_inverted_index.identify | 102 |
| abstract_inverted_index.initiate | 57 |
| abstract_inverted_index.insights | 37 |
| abstract_inverted_index.multiple | 92 |
| abstract_inverted_index.mutants. | 95 |
| abstract_inverted_index.systems: | 74 |
| abstract_inverted_index.uniquely | 119 |
| abstract_inverted_index.Hepatitis | 1 |
| abstract_inverted_index.antiviral | 123 |
| abstract_inverted_index.cirrhosis | 17 |
| abstract_inverted_index.efficient | 31 |
| abstract_inverted_index.genotypes | 93 |
| abstract_inverted_index.synthetic | 65 |
| abstract_inverted_index.advantages | 71 |
| abstract_inverted_index.background | 78 |
| abstract_inverted_index.carcinoma. | 20 |
| abstract_inverted_index.compounds, | 104 |
| abstract_inverted_index.eliminates | 76 |
| abstract_inverted_index.evolution, | 111 |
| abstract_inverted_index.increasing | 12 |
| abstract_inverted_index.infection. | 35 |
| abstract_inverted_index.widespread | 49 |
| abstract_inverted_index.worldwide, | 11 |
| abstract_inverted_index.chronically | 5 |
| abstract_inverted_index.devastating | 50 |
| abstract_inverted_index.efficiency, | 108 |
| abstract_inverted_index.infections, | 28 |
| abstract_inverted_index.replication | 58 |
| abstract_inverted_index.resistance. | 125 |
| abstract_inverted_index.demonstrate, | 115 |
| abstract_inverted_index.contaminating | 77 |
| abstract_inverted_index.hepatocellular | 19 |
| cited_by_percentile_year.max | 96 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5045645973, https://openalex.org/A5019683467 |
| countries_distinct_count | 4 |
| institutions_distinct_count | 15 |
| corresponding_institution_ids | https://openalex.org/I83399316 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8399999737739563 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.67864635 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |