Analyses of publicly available Hungatella hathewayi genomes revealed genetic distances indicating they belong to more than one species Article Swipe
Laura E. Hernández-Juárez
,
Margarita Camorlinga
,
Alfonso Méndez-Tenorio
,
Judith Flores Calderón
,
Bihua C. Huang
,
DJ Darwin R. Bandoy
,
Bart C. Weimer
,
Javier Torres
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1080/21505594.2021.1950955
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1080/21505594.2021.1950955
Hungatella hathewayi has been observed to be a member of the gut microbiome. Unfortunately, little is known about this organism in spite of being associated with human fatalities; it is important to understand virulence mechanisms and epidemiological prospective to cause disease. In this study, a patient with chronic neurologic symptoms presented to the clinic with subsequent isolation of a strain with phenotypic characteristics suggestive of Clostridium difficile. However, whole-genome sequence found the organism to be H. hathewayi. Analysis including publicly available Hungatella genomes found substantial genomic differences as compared to the type strain, indicating this isolate was not C. difficile. We examined the whole-genome of Hungatella species and related genera, using comparative genomics to fully examine species identification and toxin production. Orthogonal phylogenetic using the 16S rRNA gene and entire genome analyses that included genome distance analyses using Genome-to-Genome Distance (GGDC), Average Nucleotide Identity (ANI), and a pan-genome analysis with inclusion of available public genomes determined the speciation to be Hungatella. Two clearly differentiated groups were identified, one including a reference H. hathewayi genome (strain DSM-13,479) and a second group that was determined to be H. effluvii, which included our clinical isolate. Also, some genomes reported as H. hathewayi were found to belong to other genera, including Clostridium and Faecalicatena. We show that the Hungatella species have an open pan-genome reflecting high genomic diversity. This study highlights the importance of correctly assigning taxonomic identification, particularly in disease-associated strains, to better understand virulence and therapeutic options.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1080/21505594.2021.1950955
- https://www.tandfonline.com/doi/pdf/10.1080/21505594.2021.1950955?needAccess=true
- OA Status
- gold
- Cited By
- 13
- References
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- Related Works
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- OpenAlex ID
- https://openalex.org/W3186536935
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W3186536935Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1080/21505594.2021.1950955Digital Object Identifier
- Title
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Analyses of publicly available Hungatella hathewayi genomes revealed genetic distances indicating they belong to more than one speciesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-07-25Full publication date if available
- Authors
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Laura E. Hernández-Juárez, Margarita Camorlinga, Alfonso Méndez-Tenorio, Judith Flores Calderón, Bihua C. Huang, DJ Darwin R. Bandoy, Bart C. Weimer, Javier TorresList of authors in order
- Landing page
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https://doi.org/10.1080/21505594.2021.1950955Publisher landing page
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https://www.tandfonline.com/doi/pdf/10.1080/21505594.2021.1950955?needAccess=trueDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.tandfonline.com/doi/pdf/10.1080/21505594.2021.1950955?needAccess=trueDirect OA link when available
- Concepts
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Biology, Genome, Comparative genomics, Genetics, Genomics, Virulence, Whole genome sequencing, Phylogenetic tree, GeneTop concepts (fields/topics) attached by OpenAlex
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13Total citation count in OpenAlex
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2025: 2, 2024: 7, 2023: 4Per-year citation counts (last 5 years)
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47Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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