Analysis of Circular RNA Expression Profile in HEK 293T Cells Exposed to Ionizing Radiation Article Swipe
Ningning He
,
Yuxiao Sun
,
Mengmeng Yang
,
Qianying Lu
,
Jinhan Wang
,
Changyan Xiao
,
Yan Wang
,
Liqing Du
,
Kaihua Ji
,
Chang Xu
,
Qiang Liu
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1177/1559325819837795
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1177/1559325819837795
Radiation therapy is one of the most common cancer treatments. It is important to understand how cells respond to ionizing radiation (IR) to improve therapeutic efficacy. Circular RNAs (circRNAs) recently have been found to regulate a variety of cellular processes. However, it is poorly defined that their expression pattern and their identity in cells following IR exposure. Here, we performed high-throughput sequencing and comprehensive analysis of circRNA expression in human embryonic kidney (HEK) 293T cells before and after irradiation. We identified totally 5592 circRNAs and discovered 1038 new circRNAs. We found 158 circRNAs with significantly differential expression after IR exposure. Among them, there were 61 upregulated and 97 downregulated circRNAs. Using Gene Ontology, Kyoto Encyclopedia of Genes and Genomes pathway, and circRNA-microRNA-messenger RNA network analyses, we found the differentially expressed circRNAs might be involved in the signal pathways of oxidative phosphorylation, epithelial growth factor receptor (EGFR) tyrosine kinase inhibitor resistance, and mammalian target of rapamycin (mTOR) signaling.
Related Topics
Concepts
HEK 293 cells
KEGG
Biology
microRNA
Circular RNA
Signal transduction
Cell biology
Cancer research
Receptor tyrosine kinase
Gene
Gene expression
Computational biology
Genetics
Transcriptome
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1177/1559325819837795
- https://journals.sagepub.com/doi/pdf/10.1177/1559325819837795
- OA Status
- gold
- Cited By
- 19
- References
- 24
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2940725165
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2940725165Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1177/1559325819837795Digital Object Identifier
- Title
-
Analysis of Circular RNA Expression Profile in HEK 293T Cells Exposed to Ionizing RadiationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2019Year of publication
- Publication date
-
2019-04-01Full publication date if available
- Authors
-
Ningning He, Yuxiao Sun, Mengmeng Yang, Qianying Lu, Jinhan Wang, Changyan Xiao, Yan Wang, Liqing Du, Kaihua Ji, Chang Xu, Qiang LiuList of authors in order
- Landing page
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https://doi.org/10.1177/1559325819837795Publisher landing page
- PDF URL
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https://journals.sagepub.com/doi/pdf/10.1177/1559325819837795Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://journals.sagepub.com/doi/pdf/10.1177/1559325819837795Direct OA link when available
- Concepts
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HEK 293 cells, KEGG, Biology, microRNA, Circular RNA, Signal transduction, Cell biology, Cancer research, Receptor tyrosine kinase, Gene, Gene expression, Computational biology, Genetics, TranscriptomeTop concepts (fields/topics) attached by OpenAlex
- Cited by
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19Total citation count in OpenAlex
- Citations by year (recent)
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2024: 2, 2023: 1, 2022: 5, 2021: 3, 2020: 7Per-year citation counts (last 5 years)
- References (count)
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24Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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