Analysis of immune-related genes during Nora virus infection of <em>Drosophila melanogaster</em> using next generation sequencing Article Swipe
Wilfredo Lopez
,
Alexis M. Page
,
Darby J. Carlson
,
Brad L. Ericson
,
Mátyás Cserháti
,
Chittibabu Guda
,
Kimberly A. Carlson
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3934/microbiol.2018.1.123
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3934/microbiol.2018.1.123
Drosophila melanogaster depends upon the innate immune system to regulate and combat viral infection. This is a complex, yet widely conserved process that involves a number of immune pathways and gene interactions. In addition, expression of genes involved in immunity are differentially regulated as the organism ages. This is particularly true for viruses that demonstrate chronic infection, as is seen with Nora virus. Nora virus is a persistent non-pathogenic virus that replicates in a horizontal manner in D. melanogaster. The genes involved in the regulation of the immune response to Nora virus infection are largely unknown. In addition, the temporal response of immune response genes as a result of infection has not been examined. In this study, D. melanogaster either infected with Nora virus or left uninfected were aged for 2, 10, 20 and 30 days. The RNA from these samples was analyzed by next generation sequencing (NGS) and the resulting immune-related genes evaluated by utilizing both the PANTHER and DAVID databases, as well as comparison to lists of immune related genes and FlyBase. The data demonstrate that Nora virus infected D. melanogaster exhibit an increase in immune related gene expression over time. In addition, at day 30, the data demonstrate that a persistent immune response may occur leading to an upregulation of specific immune response genes. These results demonstrate the utility of NGS in determining the potential immune system genes involved in Nora virus replication, chronic infection and involvement of antiviral pathways.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3934/microbiol.2018.1.123
- OA Status
- gold
- Cited By
- 27
- References
- 50
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2788650023
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2788650023Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3934/microbiol.2018.1.123Digital Object Identifier
- Title
-
Analysis of immune-related genes during Nora virus infection of <em>Drosophila melanogaster</em> using next generation sequencingWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-01-01Full publication date if available
- Authors
-
Wilfredo Lopez, Alexis M. Page, Darby J. Carlson, Brad L. Ericson, Mátyás Cserháti, Chittibabu Guda, Kimberly A. CarlsonList of authors in order
- Landing page
-
https://doi.org/10.3934/microbiol.2018.1.123Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3934/microbiol.2018.1.123Direct OA link when available
- Concepts
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Immune system, Biology, Drosophila melanogaster, Gene, Virus, Innate immune system, Melanogaster, Virology, Viral replication, Immunity, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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27Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4, 2024: 2, 2023: 2, 2022: 9, 2021: 4Per-year citation counts (last 5 years)
- References (count)
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50Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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