Analysis of neuronal iron deposits in Parkinson's disease brain tissue by synchrotron x-ray spectromicroscopy Article Swipe
Jake Brooks
,
James Everett
,
Frederik Lermyte
,
Vindy Tjendana Tjhin
,
Peter J. Sadler
,
Neil D. Telling
,
Joanna F. Collingwood
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1016/j.jtemb.2020.126555
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1016/j.jtemb.2020.126555
Background \nNeuromelanin-pigmented neurons, which are highly susceptible to neurodegeneration in the Parkinson’s disease substantia nigra, harbour elevated iron levels in the diseased state. Whilst it is widely believed that neuronal iron is stored in an inert, ferric form, perturbations to normal metal homeostasis could potentially generate more reactive forms of iron capable of stimulating toxicity and cell death. However, non-disruptive analysis of brain metals is inherently challenging, since use of stains or chemical fixatives, for example, can significantly influence metal ion distributions and/or concentrations in tissues. \n \nAims \nThe aim of this study was to apply synchrotron soft x-ray spectromicroscopy to the characterisation of iron deposits and their local environment within neuromelanin-containing neurons of Parkinson’s disease substantia nigra. \n \nMethods \nSoft x-ray spectromicroscopy was applied in the form of Scanning Transmission X-ray Microscopy (STXM) to analyse resin-embedded tissue, without requirement for chemically disruptive processing or staining. Measurements were performed at the oxygen and iron K-edges in order to characterise both organic and inorganic components of anatomical tissue using a single label-free method. \n \nResults \nSTXM revealed evidence for mixed oxidation states of neuronal iron deposits associated with neuromelanin clusters in Parkinson’s disease substantia nigra. The excellent sensitivity, specificity and spatial resolution of these STXM measurements showed that the iron oxidation state varies across sub-micron length scales. \n \nConclusions \nThe label-free STXM approach is highly suited to characterising the distributions of both inorganic and organic components of anatomical tissue, and provides a proof-of-concept for investigating trace metal speciation within Parkinson’s disease neuromelanin-containing neurons.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.jtemb.2020.126555
- OA Status
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- Cited By
- 18
- References
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- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W3026928631Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.jtemb.2020.126555Digital Object Identifier
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Analysis of neuronal iron deposits in Parkinson's disease brain tissue by synchrotron x-ray spectromicroscopyWork title
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articleOpenAlex work type
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enPrimary language
- Publication year
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2020Year of publication
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2020-05-20Full publication date if available
- Authors
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Jake Brooks, James Everett, Frederik Lermyte, Vindy Tjendana Tjhin, Peter J. Sadler, Neil D. Telling, Joanna F. CollingwoodList of authors in order
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https://doi.org/10.1016/j.jtemb.2020.126555Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1016/j.jtemb.2020.126555Direct OA link when available
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Synchrotron, Parkinson's disease, Brain tissue, Chemistry, Disease, Neuroscience, Pathology, Medicine, Biology, Physics, OpticsTop concepts (fields/topics) attached by OpenAlex
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18Total citation count in OpenAlex
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2025: 1, 2024: 5, 2023: 3, 2022: 4, 2021: 5Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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