Analysis of Single- and Double-Stranded DNA Damage in Osteoblastic Cells after Hyperbaric Oxygen Exposure Article Swipe
Nele Schönrock
,
Frauke Tillmans
,
Susanne Sebens
,
Wataru Kähler
,
Sebastian Klapa
,
Bente Rieger
,
Harry Scherthan
,
Andreas Koch
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/antiox12040851
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/antiox12040851
(1) Background: Hyperbaric oxygen (HBO) exposure induces oxidative stress that may lead to DNA damage, which has been observed in human peripheral blood lymphocytes or non-human cells. Here, we investigated the impact of hyperbaric conditions on two human osteoblastic cell lines: primary human osteoblasts, HOBs, and the osteogenic tumor cell line SAOS-2. (2) Methods: Cells were exposed to HBO in an experimental hyperbaric chamber (4 ATA, 100% oxygen, 37 °C, and 4 h) or sham-exposed (1 ATA, air, 37 °C, and 4 h). DNA damage was examined before, directly after, and 24 h after exposure with an alkaline comet assay and detection of γH2AX+53BP1 colocalizing double-strand break (DSB) foci and apoptosis. The gene expression of TGFß-1, HO-1, and NQO1, involved in antioxidative functions, was measured with qRT-PCR. (3) Results: The alkaline comet assay showed significantly elevated levels of DNA damage in both cell lines after 4 h of HBO, while the DSB foci were similar to sham. γH2AX analysis indicated a slight increase in apoptosis in both cell lines. The increased expression of HO-1 in HOB and SAOS-2 directly after exposure suggested the induction of an antioxidative response in these cells. Additionally, the expression of TGF-ß1 was negatively affected in HOB cells 4 h after exposure. (4) Conclusions: in summary, this study indicates that osteoblastic cells are sensitive to the DNA-damaging effects of hyperbaric hyperoxia, with the HBO-induced DNA damage consisting largely of single-strand DNA breaks that are rapidly repaired.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/antiox12040851
- https://www.mdpi.com/2076-3921/12/4/851/pdf?version=1680574813
- OA Status
- gold
- Cited By
- 6
- References
- 64
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4362586234
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4362586234Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/antiox12040851Digital Object Identifier
- Title
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Analysis of Single- and Double-Stranded DNA Damage in Osteoblastic Cells after Hyperbaric Oxygen ExposureWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-04-01Full publication date if available
- Authors
-
Nele Schönrock, Frauke Tillmans, Susanne Sebens, Wataru Kähler, Sebastian Klapa, Bente Rieger, Harry Scherthan, Andreas KochList of authors in order
- Landing page
-
https://doi.org/10.3390/antiox12040851Publisher landing page
- PDF URL
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https://www.mdpi.com/2076-3921/12/4/851/pdf?version=1680574813Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
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https://www.mdpi.com/2076-3921/12/4/851/pdf?version=1680574813Direct OA link when available
- Concepts
-
DNA damage, Comet assay, Apoptosis, Molecular biology, Oxidative stress, Cell culture, DNA, Reactive oxygen species, Chemistry, Cell, DNA repair, Cell biology, Biology, Biochemistry, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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6Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 2, 2023: 1Per-year citation counts (last 5 years)
- References (count)
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64Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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