Analysis of Sirtuin 1 and Sirtuin 3 at Enzyme and Protein Levels in Human Breast Milk during the Neonatal Period Article Swipe
Kristina Hase
,
Laura Stahmer
,
Hadeel Shammas
,
Corinna Peter
,
Bettina Bohnhorst
,
Anibh M. Das
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/metabo11060348
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/metabo11060348
Breast feeding is regarded as the preferred nutrition modality for children during the first few months of life. It not only furthers growth and development but also is supposed to impact later life. The first 1000 days are regarded as a critical window for development, even beyond infancy. The physiological basis underlying this beneficial effect is not clear. Sirtuins are important regulatory proteins of metabolism and are supposed to play a critical role in ageing and longevity as well as in diseases. In the present study, we developed novel methods to assay sirtuin 1 and sirtuin 3 at enzyme activity (via fluorometry) and protein levels (by Western blot) in the aqueous phase and in the cell pellet of human breast milk and assessed the impact of ongoing lactation during the neonatal period. Sirtuin activities in the aqueous phase were negatively correlated with the duration of lactation in the neonatal period. There was no correlation of sirtuin activities in the cell pellet with the duration of lactation. The amounts of sirtuin 1 and sirtuin 3 measured by Western blot were negatively correlated with the lactation period.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/metabo11060348
- https://www.mdpi.com/2218-1989/11/6/348/pdf?version=1622294230
- OA Status
- gold
- Cited By
- 2
- References
- 54
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3164498474
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3164498474Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/metabo11060348Digital Object Identifier
- Title
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Analysis of Sirtuin 1 and Sirtuin 3 at Enzyme and Protein Levels in Human Breast Milk during the Neonatal PeriodWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-05-29Full publication date if available
- Authors
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Kristina Hase, Laura Stahmer, Hadeel Shammas, Corinna Peter, Bettina Bohnhorst, Anibh M. DasList of authors in order
- Landing page
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https://doi.org/10.3390/metabo11060348Publisher landing page
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https://www.mdpi.com/2218-1989/11/6/348/pdf?version=1622294230Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2218-1989/11/6/348/pdf?version=1622294230Direct OA link when available
- Concepts
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Sirtuin, Lactation, Sirtuin 1, SIRT2, Western blot, Internal medicine, Biology, Breast milk, Endocrinology, Medicine, Enzyme, Biochemistry, Pregnancy, Downregulation and upregulation, Genetics, Gene, NAD+ kinaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
- Citations by year (recent)
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2022: 2Per-year citation counts (last 5 years)
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54Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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