Analysis of the association and predictive value of hyperhomocysteinaemia for obstructive coronary artery disease Article Swipe
Hao-Yu Wu
,
Tianjiao Gao
,
Yiwei Cao
,
Jiayu Diao
,
Penghua You
,
Xiaowei Yao
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1177/03000605211033495
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1177/03000605211033495
Objective To investigate the predictive value of hyperhomocysteinaemia (HHcy) for obstructive coronary artery disease (CAD) in an Asian population in northern China. Methods This retrospective study enrolled patients at their first cardiac assessment and assigned them to an obstructive CAD group or a non-obstructive CAD group according to the coronary angiography results. HHcy was defined as a homocysteine (Hcy) level > 15 µmol/l. Results This study enrolled 2987 participants: 1172 in the non-obstructive CAD group and 1815 in the obstructive CAD group. Hcy level in the obstructive CAD group was significantly higher than in the non-obstructive CAD group. The proportion of patients with HHcy in the obstructive CAD group was significantly greater than in the non-obstructive CAD group. Multivariate logistic regression analysis demonstrated that HHcy was independently correlated with obstructive CAD in both young (aged ≤ 55 years) and old patients (aged > 55 years). HHcy showed a higher sensitivity (93.1%), specificity (86.1%) and accuracy (90.0%) for obstructive CAD. The odds ratio for HHcy was 84.2. The Kappa value (0.8) showed substantial agreement between obstructive CAD and HHcy. Conclusions HHcy was associated with obstructive CAD and may be a potentially independent risk factor for obstructive CAD with good predictive value.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1177/03000605211033495
- OA Status
- gold
- Cited By
- 7
- References
- 36
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W3186427377Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1177/03000605211033495Digital Object Identifier
- Title
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Analysis of the association and predictive value of hyperhomocysteinaemia for obstructive coronary artery diseaseWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-07-01Full publication date if available
- Authors
-
Hao-Yu Wu, Tianjiao Gao, Yiwei Cao, Jiayu Diao, Penghua You, Xiaowei YaoList of authors in order
- Landing page
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https://doi.org/10.1177/03000605211033495Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1177/03000605211033495Direct OA link when available
- Concepts
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Medicine, Coronary artery disease, Internal medicine, Homocysteine, Odds ratio, Cardiology, CAD, Logistic regression, Retrospective cohort study, Engineering drawing, EngineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
7Total citation count in OpenAlex
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2025: 1, 2024: 2, 2023: 2, 2022: 1, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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36Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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