Analytic and Integrative Framework for Understanding Human Sympathetic Arterial Baroreflex Function: Equilibrium Diagram of Arterial Pressure and Plasma Norepinephrine Level Article Swipe
Fumiyasu Yamasaki
,
Takayuki Sato
,
Kyoko Satō
,
André Diedrich
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fnins.2021.707345
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fnins.2021.707345
Background The sympathetic arterial baroreflex is a closed-loop feedback system for stabilizing arterial pressure (AP). Identification of unique functions of the closed system in humans is a challenge. Here we propose an analytic and integrative framework for identifying a static operating point and open-loop gain to characterize sympathetic arterial baroreflex in humans. Methods and Results An equilibrium diagram with two crossing functions of mechanoneural (MN) and neuromechanical (NM) arcs was analyzed during graded tilt maneuvers in seven healthy subjects. AP and plasma norepinephrine level (PNE), as a surrogate for sympathetic nerve activity, and were recorded after vagal modulation of heart function was blocked by atropine. The MN-arc curve was described as a locus of operating points during –7, 0, 15, and 60° head-up tilting (HUT) on a PNE-AP plane. The NM-arc curve was drawn as a line between operating points before and after ganglionic blockade (trimethaphan, 0.1 mg⋅ml –1 ⋅kg –1 ) during 0° or 15° HUT. Gain values were estimated from the slopes of these functional curves. Finally, an open-loop gain, which is a most important index for performance of arterial baroreflex, was given by a product of the gain values of MN (G MN ) and NM arcs (G NM ). Gain values of MN was 8.92 ± 3.07 pg⋅ml −1 ⋅mmHg −1 ; and G NM at 0° and 15° HUT were 0.61 ± 0.08 and 0.36 ± 0.05 mmHg⋅ml⋅pg –1 , respectively. A postural change from supine to 15° HUT significantly reduced the open-loop gain from 5.62 ± 0.98 to 3.75 ± 0.62. The effects of HUT on the NM arc and open-loop gain seemed to be similar to those of blood loss observed in our previous animal studies. Conclusion An equilibrium-diagram analysis contributes to a quantitative and integrative understanding of function of human sympathetic arterial baroreflex.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fnins.2021.707345
- https://www.frontiersin.org/articles/10.3389/fnins.2021.707345/pdf
- OA Status
- gold
- Cited By
- 4
- References
- 35
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3186973995
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3186973995Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fnins.2021.707345Digital Object Identifier
- Title
-
Analytic and Integrative Framework for Understanding Human Sympathetic Arterial Baroreflex Function: Equilibrium Diagram of Arterial Pressure and Plasma Norepinephrine LevelWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-07-16Full publication date if available
- Authors
-
Fumiyasu Yamasaki, Takayuki Sato, Kyoko Satō, André DiedrichList of authors in order
- Landing page
-
https://doi.org/10.3389/fnins.2021.707345Publisher landing page
- PDF URL
-
https://www.frontiersin.org/articles/10.3389/fnins.2021.707345/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.frontiersin.org/articles/10.3389/fnins.2021.707345/pdfDirect OA link when available
- Concepts
-
Baroreflex, Norepinephrine, Cardiology, Sympathetic nervous system, Internal medicine, Blood pressure, Medicine, Anesthesia, Heart rate, DopamineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
-
2023: 3, 2022: 1Per-year citation counts (last 5 years)
- References (count)
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35Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| primary_location.raw_source_name | Frontiers in Neuroscience |
| primary_location.landing_page_url | https://doi.org/10.3389/fnins.2021.707345 |
| publication_date | 2021-07-16 |
| publication_year | 2021 |
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