Analytical validation of the Belay Vantage™ assay for evaluation of MGMT promoter methylation using enzymatically converted tumorDNA from cerebrospinal fluid Article Swipe
Kala F. Schilter
,
Qian Nie
,
Jerry M. Adams
,
Rakshitha Jagadish
,
Agustín Acevedo
,
Alexandra Larson
,
Samantha A Vo
,
Brett A Domagala
,
Kyle M. Hernandez
,
Christopher Douville
,
Yuxuan Wang
,
Bradley P. Coe
,
Chetan Bettegowda
,
Honey V. Reddi
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.cancergen.2025.04.001
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.cancergen.2025.04.001
MGMT promoter methylation status (hypermethylation) is one of the strongest prognostic and predictive biomarkers in glioblastoma (GBM) and is associated with a more favorable response to alkylating chemotherapies such as Temozolomide (TMZ). Additionally, it is associated with pseudo progression in GBM, a phenomenon in which early radiographic changes after treatment are indicative of possible tumor recurrence though on histological examination it is consistent with treatment effect. Current methods for evaluation of MGMT promoter methylation status are limited to tumor tissue, requiring invasive biopsy or surgery, prompting the need for a liquid biopsy-based assay to expand and manage therapeutic interventions. The Belay Vantage™ assay evaluates MGMT promoter methylation status in cerebrospinal fluid (CSF) of individuals with known or suspected central nervous system tumors using low input DNA. The assay uses quantitative polymerase chain reaction (qPCR) on DNA extracted from CSF after enzymatic conversion and has an analytical sensitivity of 95.5 % and specificity of 100 %.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.cancergen.2025.04.001
- OA Status
- hybrid
- References
- 30
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409219289
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4409219289Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.cancergen.2025.04.001Digital Object Identifier
- Title
-
Analytical validation of the Belay Vantage™ assay for evaluation of MGMT promoter methylation using enzymatically converted tumorDNA from cerebrospinal fluidWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-04-07Full publication date if available
- Authors
-
Kala F. Schilter, Qian Nie, Jerry M. Adams, Rakshitha Jagadish, Agustín Acevedo, Alexandra Larson, Samantha A Vo, Brett A Domagala, Kyle M. Hernandez, Christopher Douville, Yuxuan Wang, Bradley P. Coe, Chetan Bettegowda, Honey V. ReddiList of authors in order
- Landing page
-
https://doi.org/10.1016/j.cancergen.2025.04.001Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1016/j.cancergen.2025.04.001Direct OA link when available
- Concepts
-
Cerebrospinal fluid, Methylation, Chromatography, Chemistry, Molecular biology, Computational biology, Biology, Cancer research, Medicine, Pathology, Biochemistry, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
30Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4409219289 |
|---|---|
| doi | https://doi.org/10.1016/j.cancergen.2025.04.001 |
| ids.doi | https://doi.org/10.1016/j.cancergen.2025.04.001 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40250264 |
| ids.openalex | https://openalex.org/W4409219289 |
| fwci | 0.0 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D019175 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | DNA Methylation |
| mesh[2].qualifier_ui | Q000235 |
| mesh[2].descriptor_ui | D011401 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | genetics |
| mesh[2].descriptor_name | Promoter Regions, Genetic |
| mesh[3].qualifier_ui | Q000235 |
| mesh[3].descriptor_ui | D045643 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | genetics |
| mesh[3].descriptor_name | DNA Repair Enzymes |
| mesh[4].qualifier_ui | Q000235 |
| mesh[4].descriptor_ui | D015254 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | genetics |
| mesh[4].descriptor_name | DNA Modification Methylases |
| mesh[5].qualifier_ui | Q000235 |
| mesh[5].descriptor_ui | D025521 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | genetics |
| mesh[5].descriptor_name | Tumor Suppressor Proteins |
| mesh[6].qualifier_ui | Q000235 |
| mesh[6].descriptor_ui | D005909 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | genetics |
| mesh[6].descriptor_name | Glioblastoma |
| mesh[7].qualifier_ui | Q000134 |
| mesh[7].descriptor_ui | D005909 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | cerebrospinal fluid |
| mesh[7].descriptor_name | Glioblastoma |
| mesh[8].qualifier_ui | Q000235 |
| mesh[8].descriptor_ui | D014408 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | genetics |
| mesh[8].descriptor_name | Biomarkers, Tumor |
| mesh[9].qualifier_ui | Q000134 |
| mesh[9].descriptor_ui | D014408 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | cerebrospinal fluid |
| mesh[9].descriptor_name | Biomarkers, Tumor |
| mesh[10].qualifier_ui | Q000134 |
| mesh[10].descriptor_ui | D004273 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | cerebrospinal fluid |
| mesh[10].descriptor_name | DNA, Neoplasm |
| mesh[11].qualifier_ui | Q000235 |
| mesh[11].descriptor_ui | D004273 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | genetics |
| mesh[11].descriptor_name | DNA, Neoplasm |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D008297 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Male |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D005260 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Female |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D008875 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Middle Aged |
| mesh[15].qualifier_ui | Q000235 |
| mesh[15].descriptor_ui | D001932 |
| mesh[15].is_major_topic | True |
| mesh[15].qualifier_name | genetics |
| mesh[15].descriptor_name | Brain Neoplasms |
| mesh[16].qualifier_ui | Q000134 |
| mesh[16].descriptor_ui | D001932 |
| mesh[16].is_major_topic | True |
| mesh[16].qualifier_name | cerebrospinal fluid |
| mesh[16].descriptor_name | Brain Neoplasms |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D000077204 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Temozolomide |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D000328 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Adult |
| type | article |
| title | Analytical validation of the Belay Vantage™ assay for evaluation of MGMT promoter methylation using enzymatically converted tumorDNA from cerebrospinal fluid |
| biblio.issue | |
| biblio.volume | 294-295 |
| biblio.last_page | 98 |
| biblio.first_page | 94 |
| topics[0].id | https://openalex.org/T10129 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2716 |
| topics[0].subfield.display_name | Genetics |
| topics[0].display_name | Glioma Diagnosis and Treatment |
| topics[1].id | https://openalex.org/T10269 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9973999857902527 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Epigenetics and DNA Methylation |
| topics[2].id | https://openalex.org/T11600 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9940999746322632 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2740 |
| topics[2].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[2].display_name | Brain Metastases and Treatment |
| is_xpac | False |
| apc_list.value | 3060 |
| apc_list.currency | USD |
| apc_list.value_usd | 3060 |
| apc_paid.value | 3060 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 3060 |
| concepts[0].id | https://openalex.org/C2779651940 |
| concepts[0].level | 2 |
| concepts[0].score | 0.7811259031295776 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q54196 |
| concepts[0].display_name | Cerebrospinal fluid |
| concepts[1].id | https://openalex.org/C33288867 |
| concepts[1].level | 3 |
| concepts[1].score | 0.6629147529602051 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q518328 |
| concepts[1].display_name | Methylation |
| concepts[2].id | https://openalex.org/C43617362 |
| concepts[2].level | 1 |
| concepts[2].score | 0.45817869901657104 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q170050 |
| concepts[2].display_name | Chromatography |
| concepts[3].id | https://openalex.org/C185592680 |
| concepts[3].level | 0 |
| concepts[3].score | 0.41277679800987244 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[3].display_name | Chemistry |
| concepts[4].id | https://openalex.org/C153911025 |
| concepts[4].level | 1 |
| concepts[4].score | 0.40570738911628723 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q7202 |
| concepts[4].display_name | Molecular biology |
| concepts[5].id | https://openalex.org/C70721500 |
| concepts[5].level | 1 |
| concepts[5].score | 0.3968586325645447 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q177005 |
| concepts[5].display_name | Computational biology |
| concepts[6].id | https://openalex.org/C86803240 |
| concepts[6].level | 0 |
| concepts[6].score | 0.32389888167381287 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[6].display_name | Biology |
| concepts[7].id | https://openalex.org/C502942594 |
| concepts[7].level | 1 |
| concepts[7].score | 0.32305508852005005 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[7].display_name | Cancer research |
| concepts[8].id | https://openalex.org/C71924100 |
| concepts[8].level | 0 |
| concepts[8].score | 0.29449546337127686 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[8].display_name | Medicine |
| concepts[9].id | https://openalex.org/C142724271 |
| concepts[9].level | 1 |
| concepts[9].score | 0.29309260845184326 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[9].display_name | Pathology |
| concepts[10].id | https://openalex.org/C55493867 |
| concepts[10].level | 1 |
| concepts[10].score | 0.24951419234275818 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[10].display_name | Biochemistry |
| concepts[11].id | https://openalex.org/C104317684 |
| concepts[11].level | 2 |
| concepts[11].score | 0.10399502515792847 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[11].display_name | Gene |
| keywords[0].id | https://openalex.org/keywords/cerebrospinal-fluid |
| keywords[0].score | 0.7811259031295776 |
| keywords[0].display_name | Cerebrospinal fluid |
| keywords[1].id | https://openalex.org/keywords/methylation |
| keywords[1].score | 0.6629147529602051 |
| keywords[1].display_name | Methylation |
| keywords[2].id | https://openalex.org/keywords/chromatography |
| keywords[2].score | 0.45817869901657104 |
| keywords[2].display_name | Chromatography |
| keywords[3].id | https://openalex.org/keywords/chemistry |
| keywords[3].score | 0.41277679800987244 |
| keywords[3].display_name | Chemistry |
| keywords[4].id | https://openalex.org/keywords/molecular-biology |
| keywords[4].score | 0.40570738911628723 |
| keywords[4].display_name | Molecular biology |
| keywords[5].id | https://openalex.org/keywords/computational-biology |
| keywords[5].score | 0.3968586325645447 |
| keywords[5].display_name | Computational biology |
| keywords[6].id | https://openalex.org/keywords/biology |
| keywords[6].score | 0.32389888167381287 |
| keywords[6].display_name | Biology |
| keywords[7].id | https://openalex.org/keywords/cancer-research |
| keywords[7].score | 0.32305508852005005 |
| keywords[7].display_name | Cancer research |
| keywords[8].id | https://openalex.org/keywords/medicine |
| keywords[8].score | 0.29449546337127686 |
| keywords[8].display_name | Medicine |
| keywords[9].id | https://openalex.org/keywords/pathology |
| keywords[9].score | 0.29309260845184326 |
| keywords[9].display_name | Pathology |
| keywords[10].id | https://openalex.org/keywords/biochemistry |
| keywords[10].score | 0.24951419234275818 |
| keywords[10].display_name | Biochemistry |
| keywords[11].id | https://openalex.org/keywords/gene |
| keywords[11].score | 0.10399502515792847 |
| keywords[11].display_name | Gene |
| language | en |
| locations[0].id | doi:10.1016/j.cancergen.2025.04.001 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4210168666 |
| locations[0].source.issn | 2210-7762, 2210-7770 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 2210-7762 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Cancer Genetics |
| locations[0].source.host_organization | https://openalex.org/P4310320990 |
| locations[0].source.host_organization_name | Elsevier BV |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320990 |
| locations[0].source.host_organization_lineage_names | Elsevier BV |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Cancer Genetics |
| locations[0].landing_page_url | https://doi.org/10.1016/j.cancergen.2025.04.001 |
| locations[1].id | pmid:40250264 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Cancer genetics |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40250264 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5041777843 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-8061-0842 |
| authorships[0].author.display_name | Kala F. Schilter |
| authorships[0].affiliations[0].raw_affiliation_string | Belay Diagnostics, Suite 530, 1375W. Fulton St, Chicago, IL 60607, USA. |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Kala F Schilter |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Belay Diagnostics, Suite 530, 1375W. Fulton St, Chicago, IL 60607, USA. |
| authorships[1].author.id | https://openalex.org/A5074920977 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-5394-2382 |
| authorships[1].author.display_name | Qian Nie |
| authorships[1].affiliations[0].raw_affiliation_string | Belay Diagnostics, Suite 530, 1375W. Fulton St, Chicago, IL 60607, USA. |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Qian Nie |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Belay Diagnostics, Suite 530, 1375W. Fulton St, Chicago, IL 60607, USA. |
| authorships[2].author.id | https://openalex.org/A5084729140 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-4360-8628 |
| authorships[2].author.display_name | Jerry M. Adams |
| authorships[2].affiliations[0].raw_affiliation_string | Belay Diagnostics, Suite 530, 1375W. Fulton St, Chicago, IL 60607, USA. |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Jennifer N Adams |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Belay Diagnostics, Suite 530, 1375W. Fulton St, Chicago, IL 60607, USA. |
| authorships[3].author.id | https://openalex.org/A5051166070 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Rakshitha Jagadish |
| authorships[3].affiliations[0].raw_affiliation_string | Belay Diagnostics, Suite 530, 1375W. Fulton St, Chicago, IL 60607, USA. |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Rakshitha Jagadish |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Belay Diagnostics, Suite 530, 1375W. Fulton St, Chicago, IL 60607, USA. |
| authorships[4].author.id | https://openalex.org/A5006682446 |
| authorships[4].author.orcid | https://orcid.org/0000-0001-8286-8361 |
| authorships[4].author.display_name | Agustín Acevedo |
| authorships[4].affiliations[0].raw_affiliation_string | Belay Diagnostics, Suite 530, 1375W. Fulton St, Chicago, IL 60607, USA. |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Anthony Acevedo |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Belay Diagnostics, Suite 530, 1375W. Fulton St, Chicago, IL 60607, USA. |
| authorships[5].author.id | https://openalex.org/A5065190245 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-2163-2125 |
| authorships[5].author.display_name | Alexandra Larson |
| authorships[5].affiliations[0].raw_affiliation_string | Belay Diagnostics, Suite 530, 1375W. Fulton St, Chicago, IL 60607, USA. |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Alexandra Larson |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Belay Diagnostics, Suite 530, 1375W. Fulton St, Chicago, IL 60607, USA. |
| authorships[6].author.id | https://openalex.org/A5117017737 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Samantha A Vo |
| authorships[6].affiliations[0].raw_affiliation_string | Belay Diagnostics, Suite 530, 1375W. Fulton St, Chicago, IL 60607, USA. |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Samantha A Vo |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Belay Diagnostics, Suite 530, 1375W. Fulton St, Chicago, IL 60607, USA. |
| authorships[7].author.id | https://openalex.org/A5117017738 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Brett A Domagala |
| authorships[7].affiliations[0].raw_affiliation_string | Belay Diagnostics, Suite 530, 1375W. Fulton St, Chicago, IL 60607, USA. |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Brett A Domagala |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Belay Diagnostics, Suite 530, 1375W. Fulton St, Chicago, IL 60607, USA. |
| authorships[8].author.id | https://openalex.org/A5074698371 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-8267-644X |
| authorships[8].author.display_name | Kyle M. Hernandez |
| authorships[8].affiliations[0].raw_affiliation_string | Belay Diagnostics, Suite 530, 1375W. Fulton St, Chicago, IL 60607, USA. |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Kyle M Hernandez |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Belay Diagnostics, Suite 530, 1375W. Fulton St, Chicago, IL 60607, USA. |
| authorships[9].author.id | https://openalex.org/A5028941911 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-2510-4151 |
| authorships[9].author.display_name | Christopher Douville |
| authorships[9].affiliations[0].raw_affiliation_string | Belay Diagnostics, Suite 530, 1375W. Fulton St, Chicago, IL 60607, USA. |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Christopher Douville |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Belay Diagnostics, Suite 530, 1375W. Fulton St, Chicago, IL 60607, USA. |
| authorships[10].author.id | https://openalex.org/A5100375980 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-2932-6042 |
| authorships[10].author.display_name | Yuxuan Wang |
| authorships[10].affiliations[0].raw_affiliation_string | Belay Diagnostics, Suite 530, 1375W. Fulton St, Chicago, IL 60607, USA. |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Yuxuan Wang |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Belay Diagnostics, Suite 530, 1375W. Fulton St, Chicago, IL 60607, USA. |
| authorships[11].author.id | https://openalex.org/A5022167873 |
| authorships[11].author.orcid | https://orcid.org/0000-0001-8471-4016 |
| authorships[11].author.display_name | Bradley P. Coe |
| authorships[11].affiliations[0].raw_affiliation_string | Belay Diagnostics, Suite 530, 1375W. Fulton St, Chicago, IL 60607, USA. |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Brian Coe |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Belay Diagnostics, Suite 530, 1375W. Fulton St, Chicago, IL 60607, USA. |
| authorships[12].author.id | https://openalex.org/A5069558252 |
| authorships[12].author.orcid | https://orcid.org/0000-0001-9991-7123 |
| authorships[12].author.display_name | Chetan Bettegowda |
| authorships[12].affiliations[0].raw_affiliation_string | Belay Diagnostics, Suite 530, 1375W. Fulton St, Chicago, IL 60607, USA. |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Chetan Bettegowda |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Belay Diagnostics, Suite 530, 1375W. Fulton St, Chicago, IL 60607, USA. |
| authorships[13].author.id | https://openalex.org/A5073383381 |
| authorships[13].author.orcid | https://orcid.org/0000-0003-1280-9993 |
| authorships[13].author.display_name | Honey V. Reddi |
| authorships[13].affiliations[0].raw_affiliation_string | Belay Diagnostics, Suite 530, 1375W. Fulton St, Chicago, IL 60607, USA. Electronic address: [email protected]. |
| authorships[13].author_position | last |
| authorships[13].raw_author_name | Honey V Reddi |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Belay Diagnostics, Suite 530, 1375W. Fulton St, Chicago, IL 60607, USA. Electronic address: [email protected]. |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.1016/j.cancergen.2025.04.001 |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Analytical validation of the Belay Vantage™ assay for evaluation of MGMT promoter methylation using enzymatically converted tumorDNA from cerebrospinal fluid |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10129 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2716 |
| primary_topic.subfield.display_name | Genetics |
| primary_topic.display_name | Glioma Diagnosis and Treatment |
| related_works | https://openalex.org/W2060257772, https://openalex.org/W2058773221, https://openalex.org/W2003001535, https://openalex.org/W2081363855, https://openalex.org/W1972670736, https://openalex.org/W2020948693, https://openalex.org/W2075327691, https://openalex.org/W2241817324, https://openalex.org/W2504770874, https://openalex.org/W1995974809 |
| cited_by_count | 0 |
| locations_count | 2 |
| best_oa_location.id | doi:10.1016/j.cancergen.2025.04.001 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4210168666 |
| best_oa_location.source.issn | 2210-7762, 2210-7770 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 2210-7762 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Cancer Genetics |
| best_oa_location.source.host_organization | https://openalex.org/P4310320990 |
| best_oa_location.source.host_organization_name | Elsevier BV |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| best_oa_location.source.host_organization_lineage_names | Elsevier BV |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Cancer Genetics |
| best_oa_location.landing_page_url | https://doi.org/10.1016/j.cancergen.2025.04.001 |
| primary_location.id | doi:10.1016/j.cancergen.2025.04.001 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4210168666 |
| primary_location.source.issn | 2210-7762, 2210-7770 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 2210-7762 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Cancer Genetics |
| primary_location.source.host_organization | https://openalex.org/P4310320990 |
| primary_location.source.host_organization_name | Elsevier BV |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| primary_location.source.host_organization_lineage_names | Elsevier BV |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Cancer Genetics |
| primary_location.landing_page_url | https://doi.org/10.1016/j.cancergen.2025.04.001 |
| publication_date | 2025-04-07 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W1906781133, https://openalex.org/W2537525253, https://openalex.org/W2124059304, https://openalex.org/W4399721741, https://openalex.org/W2013816626, https://openalex.org/W4315643346, https://openalex.org/W2590936958, https://openalex.org/W6678084451, https://openalex.org/W2105100844, https://openalex.org/W4402170462, https://openalex.org/W1869160040, https://openalex.org/W2170356111, https://openalex.org/W2112014411, https://openalex.org/W2950199861, https://openalex.org/W2038523604, https://openalex.org/W3092019124, https://openalex.org/W4397032493, https://openalex.org/W4393115727, https://openalex.org/W4409731471, https://openalex.org/W6851171718, https://openalex.org/W2152615936, https://openalex.org/W4213034575, https://openalex.org/W4402620649, https://openalex.org/W2154526619, https://openalex.org/W2034535752, https://openalex.org/W2891484912, https://openalex.org/W1995010744, https://openalex.org/W2902360852, https://openalex.org/W2121205576, https://openalex.org/W4362523916 |
| referenced_works_count | 30 |
| abstract_inverted_index.% | 149 |
| abstract_inverted_index.a | 21, 41, 89 |
| abstract_inverted_index.%. | 154 |
| abstract_inverted_index.an | 144 |
| abstract_inverted_index.as | 29 |
| abstract_inverted_index.in | 14, 39, 43, 108 |
| abstract_inverted_index.is | 5, 18, 34, 61 |
| abstract_inverted_index.it | 33, 60 |
| abstract_inverted_index.of | 7, 52, 70, 112, 147, 152 |
| abstract_inverted_index.on | 57, 134 |
| abstract_inverted_index.or | 83, 116 |
| abstract_inverted_index.to | 25, 77, 93 |
| abstract_inverted_index.100 | 153 |
| abstract_inverted_index.CSF | 138 |
| abstract_inverted_index.DNA | 135 |
| abstract_inverted_index.The | 99, 126 |
| abstract_inverted_index.and | 11, 17, 95, 142, 150 |
| abstract_inverted_index.are | 50, 75 |
| abstract_inverted_index.for | 68, 88 |
| abstract_inverted_index.has | 143 |
| abstract_inverted_index.low | 123 |
| abstract_inverted_index.one | 6 |
| abstract_inverted_index.the | 8, 86 |
| abstract_inverted_index.95.5 | 148 |
| abstract_inverted_index.DNA. | 125 |
| abstract_inverted_index.GBM, | 40 |
| abstract_inverted_index.MGMT | 0, 71, 104 |
| abstract_inverted_index.from | 137 |
| abstract_inverted_index.more | 22 |
| abstract_inverted_index.need | 87 |
| abstract_inverted_index.such | 28 |
| abstract_inverted_index.uses | 128 |
| abstract_inverted_index.with | 20, 36, 63, 114 |
| abstract_inverted_index.(CSF) | 111 |
| abstract_inverted_index.(GBM) | 16 |
| abstract_inverted_index.Belay | 100 |
| abstract_inverted_index.after | 48, 139 |
| abstract_inverted_index.assay | 92, 102, 127 |
| abstract_inverted_index.chain | 131 |
| abstract_inverted_index.early | 45 |
| abstract_inverted_index.fluid | 110 |
| abstract_inverted_index.input | 124 |
| abstract_inverted_index.known | 115 |
| abstract_inverted_index.tumor | 54, 78 |
| abstract_inverted_index.using | 122 |
| abstract_inverted_index.which | 44 |
| abstract_inverted_index.(TMZ). | 31 |
| abstract_inverted_index.(qPCR) | 133 |
| abstract_inverted_index.biopsy | 82 |
| abstract_inverted_index.expand | 94 |
| abstract_inverted_index.liquid | 90 |
| abstract_inverted_index.manage | 96 |
| abstract_inverted_index.pseudo | 37 |
| abstract_inverted_index.status | 3, 74, 107 |
| abstract_inverted_index.system | 120 |
| abstract_inverted_index.though | 56 |
| abstract_inverted_index.tumors | 121 |
| abstract_inverted_index.Current | 66 |
| abstract_inverted_index.central | 118 |
| abstract_inverted_index.changes | 47 |
| abstract_inverted_index.effect. | 65 |
| abstract_inverted_index.limited | 76 |
| abstract_inverted_index.methods | 67 |
| abstract_inverted_index.nervous | 119 |
| abstract_inverted_index.tissue, | 79 |
| abstract_inverted_index.invasive | 81 |
| abstract_inverted_index.possible | 53 |
| abstract_inverted_index.promoter | 1, 72, 105 |
| abstract_inverted_index.reaction | 132 |
| abstract_inverted_index.response | 24 |
| abstract_inverted_index.surgery, | 84 |
| abstract_inverted_index.enzymatic | 140 |
| abstract_inverted_index.evaluates | 103 |
| abstract_inverted_index.extracted | 136 |
| abstract_inverted_index.favorable | 23 |
| abstract_inverted_index.prompting | 85 |
| abstract_inverted_index.requiring | 80 |
| abstract_inverted_index.strongest | 9 |
| abstract_inverted_index.suspected | 117 |
| abstract_inverted_index.treatment | 49, 64 |
| abstract_inverted_index.Vantage™ | 101 |
| abstract_inverted_index.alkylating | 26 |
| abstract_inverted_index.analytical | 145 |
| abstract_inverted_index.associated | 19, 35 |
| abstract_inverted_index.biomarkers | 13 |
| abstract_inverted_index.consistent | 62 |
| abstract_inverted_index.conversion | 141 |
| abstract_inverted_index.evaluation | 69 |
| abstract_inverted_index.indicative | 51 |
| abstract_inverted_index.phenomenon | 42 |
| abstract_inverted_index.polymerase | 130 |
| abstract_inverted_index.predictive | 12 |
| abstract_inverted_index.prognostic | 10 |
| abstract_inverted_index.recurrence | 55 |
| abstract_inverted_index.examination | 59 |
| abstract_inverted_index.individuals | 113 |
| abstract_inverted_index.methylation | 2, 73, 106 |
| abstract_inverted_index.progression | 38 |
| abstract_inverted_index.sensitivity | 146 |
| abstract_inverted_index.specificity | 151 |
| abstract_inverted_index.therapeutic | 97 |
| abstract_inverted_index.Temozolomide | 30 |
| abstract_inverted_index.biopsy-based | 91 |
| abstract_inverted_index.glioblastoma | 15 |
| abstract_inverted_index.histological | 58 |
| abstract_inverted_index.quantitative | 129 |
| abstract_inverted_index.radiographic | 46 |
| abstract_inverted_index.Additionally, | 32 |
| abstract_inverted_index.cerebrospinal | 109 |
| abstract_inverted_index.chemotherapies | 27 |
| abstract_inverted_index.interventions. | 98 |
| abstract_inverted_index.(hypermethylation) | 4 |
| cited_by_percentile_year | |
| countries_distinct_count | 0 |
| institutions_distinct_count | 14 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/2 |
| sustainable_development_goals[0].score | 0.41999998688697815 |
| sustainable_development_goals[0].display_name | Zero hunger |
| citation_normalized_percentile.value | 0.16074555 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |