Anaplastic Thyroid Carcinoma: Cytomorphologic Features on Fine-Needle Aspiration and Associated Diagnostic Challenges Article Swipe
Peter Podany
,
Rita Abi‐Raad
,
Andrea Barbieri
,
James Garritano
,
Manju L. Prasad
,
Guoping Cai
,
Adebowale Adeniran
,
Syed M. Gilani
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1093/ajcp/aqab159
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1093/ajcp/aqab159
Objectives Anaplastic thyroid carcinoma (ATC) is an aggressive malignancy, and early diagnosis, often aided by fine-needle aspiration (FNA), is key to improving patient prognosis. While the current literature describes some of the cytologic features (CFs) of this entity, a comprehensive examination of the CFs has not yet been performed. Methods We retrospectively searched our electronic database for ATC cases with available slides between January 2008 and December 2019. Cases were examined for 22 CFs and compared with a control group of differentiated thyroid carcinoma. Results A total of 18 ATC cases meeting our inclusion criteria were identified. Most cases showed moderate to high cellularity (83%) and epithelioid cytomorphology (83%). Architecture included either predominantly groups/clusters of tumor cells (56%) or single tumor cells (44%). The other CFs were as follows: nuclear enlargement (100%), nuclear crowding (89%), nuclear membrane irregularities (100%), multinucleated tumor cells (33%), and background acute inflammatory cells (50%). Of the CFs examined, statistically significant differences between ATC and the control groups were found in the following: nuclear pleomorphism, coarse/clumped chromatin, macronucleoli, apoptosis, and necrosis. Conclusions Identification of key CFs in FNA coupled with the clinical history aids in the diagnosis of ATC and helps distinguish it from other mimickers.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/ajcp/aqab159
- https://academic.oup.com/ajcp/article-pdf/157/4/608/43223350/aqab159.pdf
- OA Status
- bronze
- Cited By
- 14
- References
- 24
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4205453821
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4205453821Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/ajcp/aqab159Digital Object Identifier
- Title
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Anaplastic Thyroid Carcinoma: Cytomorphologic Features on Fine-Needle Aspiration and Associated Diagnostic ChallengesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-08-20Full publication date if available
- Authors
-
Peter Podany, Rita Abi‐Raad, Andrea Barbieri, James Garritano, Manju L. Prasad, Guoping Cai, Adebowale Adeniran, Syed M. GilaniList of authors in order
- Landing page
-
https://doi.org/10.1093/ajcp/aqab159Publisher landing page
- PDF URL
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https://academic.oup.com/ajcp/article-pdf/157/4/608/43223350/aqab159.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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bronzeOpen access status per OpenAlex
- OA URL
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https://academic.oup.com/ajcp/article-pdf/157/4/608/43223350/aqab159.pdfDirect OA link when available
- Concepts
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Cytopathology, Fine-needle aspiration, Medicine, Pathology, Pleomorphism (cytology), Thyroid, Nuclear atypia, Malignancy, Anaplastic carcinoma, Thyroid carcinoma, Carcinoma, Cytology, Biopsy, Internal medicine, ImmunohistochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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14Total citation count in OpenAlex
- Citations by year (recent)
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2025: 5, 2024: 4, 2023: 5Per-year citation counts (last 5 years)
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24Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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