Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1 Article Swipe
Julie Sellau
,
Marie Groneberg
,
Helena Fehling
,
Thorsten Thye
,
Stefan Hoenow
,
Claudia Marggraff
,
Leonie M. Weskamm
,
Charlotte Hansen
,
Stephanie Stanelle‐Bertram
,
Svenja Kuehl
,
Jill Noll
,
Vincent Wolf
,
Nahla Galal Metwally
,
Sven Hendrik Hagen
,
Christoph Dorn
,
Julia Wernecke
,
Harald Ittrich
,
Egbert Tannich
,
Thomas Jacobs
,
Iris Bruchhaus
,
Marcus Altfeld
,
Hannelore Lotter
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1038/s41467-020-17260-y
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1038/s41467-020-17260-y
Hepatic amebiasis, predominantly occurring in men, is a focal destruction of the liver due to the invading protozoan Entamoeba histolytica . Classical monocytes as well as testosterone are identified to have important functions for the development of hepatic amebiasis in mice, but a link between testosterone and monocytes has not been identified. Here we show that testosterone treatment induces proinflammatory responses in human and mouse classical monocytes. When treated with 5α-dihydrotestosterone, a strong androgen receptor ligand, human classical monocytes increase CXCL1 production in the presence of Entamoeba histolytica antigens. Moreover, plasma testosterone levels of individuals undergoing transgender procedure correlate positively with the TNF and CXCL1 secretion from their cultured peripheral blood mononuclear cells following lipopolysaccharide stimulation. Finally, testosterone substitution of castrated male mice increases the frequency of TNF/CXCL1-producing classical monocytes during hepatic amebiasis, supporting the hypothesis that the effects of androgens may contribute to an increased risk of developing monocyte-mediated pathologies.
Related Topics
Concepts
CXCL1
Endocrinology
Monocyte
Peripheral blood mononuclear cell
Internal medicine
Testosterone (patch)
Tumor necrosis factor alpha
Androgen receptor
Entamoeba histolytica
Proinflammatory cytokine
Biology
Lipopolysaccharide
Immunology
Receptor
Medicine
Inflammation
Chemokine
In vitro
Biochemistry
Cancer
Prostate cancer
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41467-020-17260-y
- https://www.nature.com/articles/s41467-020-17260-y.pdf
- OA Status
- gold
- Cited By
- 44
- References
- 73
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3041001805
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3041001805Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41467-020-17260-yDigital Object Identifier
- Title
-
Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-07-10Full publication date if available
- Authors
-
Julie Sellau, Marie Groneberg, Helena Fehling, Thorsten Thye, Stefan Hoenow, Claudia Marggraff, Leonie M. Weskamm, Charlotte Hansen, Stephanie Stanelle‐Bertram, Svenja Kuehl, Jill Noll, Vincent Wolf, Nahla Galal Metwally, Sven Hendrik Hagen, Christoph Dorn, Julia Wernecke, Harald Ittrich, Egbert Tannich, Thomas Jacobs, Iris Bruchhaus, Marcus Altfeld, Hannelore LotterList of authors in order
- Landing page
-
https://doi.org/10.1038/s41467-020-17260-yPublisher landing page
- PDF URL
-
https://www.nature.com/articles/s41467-020-17260-y.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.nature.com/articles/s41467-020-17260-y.pdfDirect OA link when available
- Concepts
-
CXCL1, Endocrinology, Monocyte, Peripheral blood mononuclear cell, Internal medicine, Testosterone (patch), Tumor necrosis factor alpha, Androgen receptor, Entamoeba histolytica, Proinflammatory cytokine, Biology, Lipopolysaccharide, Immunology, Receptor, Medicine, Inflammation, Chemokine, In vitro, Biochemistry, Cancer, Prostate cancerTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
44Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 8, 2024: 10, 2023: 10, 2022: 7, 2021: 5Per-year citation counts (last 5 years)
- References (count)
-
73Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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