Anesthesiology Article Swipe
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· 2023
· Open Access
·
· DOI: https://doi.org/10.1097/aln.0000000000004717
· OA: W4385665771
This prospective, nonrandomized, crossover study compared the effects of three positive end-expiratory pressure (PEEP) strategies (fixed level 8 cm H 2 0, titration to the highest static compliance, or PEEP targeting a zero end-expiratory transpulmonary pressure) at different surgical positions on end-expiratory transpulmonary pressure (primary outcome) and respiratory mechanics, lung volumes, gas exchange, and hemodynamics (secondary outcomes).Compared to fixed PEEP or zero end-expiratory transpulmonary pressure strategies, titration to the highest static compliance resulted in a slightly negative end-expiratory transpulmonary pressure that was associated with improved respiratory mechanics, lung volumes, oxygenation, and preservation of cardiac output.
