Angiopoietin-1 Upregulates Cancer Cell Motility in Colorectal Cancer Liver Metastases through Actin-Related Protein 2/3 Article Swipe
Miran Rada
,
Audrey Kapelanski-Lamoureux
,
Migmar Tsamchoe
,
Stephanie Petrillo
,
Anthoula Lazaris
,
Peter Metrakos
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/cancers14102540
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/cancers14102540
Resistance to anti-angiogenic therapy is a major challenge in the treatment of colorectal cancer liver metastases (CRCLMs). Vessel co-option has been identified as a key contributor to anti-angiogenic therapy resistance in CRCLMs. Recently, we identified a positive correlation between the expression of Angiopoietin1 (Ang1) in the liver and the development of vessel co-opting CRCLM lesions in vivo. However, the mechanisms underlying its stimulation of vessel co-option are unclear. Herein, we demonstrated Ang1 as a positive regulator of actin-related protein 2/3 (ARP2/3) expression in cancer cells, in vitro and in vivo, which is known to be essential for the formation of vessel co-option in CRCLM. Significantly, Ang1-dependent ARP2/3 expression was impaired in the cancer cells upon Tie2 or PI3K/AKT inhibition in vitro. Taken together, our results suggest novel mechanisms by which Ang1 confers the development of vessel co-option in CRCLM, which, targeting this pathway, may serve as promising therapeutic targets to overcome the development of vessel co-option in CRCLM.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/cancers14102540
- https://www.mdpi.com/2072-6694/14/10/2540/pdf?version=1653363333
- OA Status
- gold
- Cited By
- 16
- References
- 60
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4281252081
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4281252081Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/cancers14102540Digital Object Identifier
- Title
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Angiopoietin-1 Upregulates Cancer Cell Motility in Colorectal Cancer Liver Metastases through Actin-Related Protein 2/3Work title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-05-21Full publication date if available
- Authors
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Miran Rada, Audrey Kapelanski-Lamoureux, Migmar Tsamchoe, Stephanie Petrillo, Anthoula Lazaris, Peter MetrakosList of authors in order
- Landing page
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https://doi.org/10.3390/cancers14102540Publisher landing page
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https://www.mdpi.com/2072-6694/14/10/2540/pdf?version=1653363333Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
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https://www.mdpi.com/2072-6694/14/10/2540/pdf?version=1653363333Direct OA link when available
- Concepts
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In vivo, Cancer research, Motility, PI3K/AKT/mTOR pathway, In vitro, Metastasis, Cancer, Chemistry, Colorectal cancer, Protein kinase B, Cell biology, Medicine, Internal medicine, Signal transduction, Biology, Biochemistry, BiotechnologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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16Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4, 2024: 4, 2023: 3, 2022: 5Per-year citation counts (last 5 years)
- References (count)
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60Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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