Angiotensin-Converting Enzyme 2 (ACE2) in the Context of Respiratory Diseases and Its Importance in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Article Swipe
Enrique Ambrocio-Ortiz
,
Gloría Pérez-Rubio
,
Alma D. Del Ángel-Pablo
,
Ivette Buendía-Roldán
,
Leslie Chávez‐Galán
,
Rafael de Jesús Hernández-Zenteno
,
Alejandra Ramírez‐Venegas
,
Jorge Rojas‐Serrano
,
Mayra Mejía
,
Rogelio Pérez‐Padilla
,
Cristóbal Guadarrama-Pérez
,
Ramcés Falfán‐Valencia
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/ph14080805
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/ph14080805
Angiotensin-Converting Enzyme 2 (ACE2) is an 805 amino acid protein encoded by the ACE2 gene expressed in various human cells, especially in those located in the epithelia. The primary function of ACE2 is to produce angiotensin (1–7) from angiotensin II (Ang II). The current research has described the importance of ACE2 and Ang (1–7) in alternative routes of the renin-angiotensin system (RAS) that promote the downregulation of fibrosis, inflammation, and oxidative stress processes in a great variety of diseases, such as hypertension, acute lung injury, liver cirrhosis, and kidney abnormalities. Investigations into the recent outbreak of the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have revealed the importance of ACE2 during infection and its role in recognizing viral binding proteins through interactions with specific amino acids of this enzyme. Additionally, the ACE2 expression in several organs has allowed us to understand the clinical picture related to the infection caused by SARS-CoV-2. This review aims to provide context for the functions and importance of ACE2 with regards to SARS-CoV-2 in the general clinical aspect and its impact on other diseases, especially respiratory diseases.
Related Topics
Concepts
Angiotensin-converting enzyme 2
Context (archaeology)
Renin–angiotensin system
Medicine
Angiotensin II
Respiratory system
Coronavirus
Lung
Immunology
Severe acute respiratory syndrome
Biology
Internal medicine
Coronavirus disease 2019 (COVID-19)
Disease
Blood pressure
Infectious disease (medical specialty)
Paleontology
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/ph14080805
- https://www.mdpi.com/1424-8247/14/8/805/pdf?version=1629266913
- OA Status
- gold
- Cited By
- 7
- References
- 105
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3193622638
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3193622638Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ph14080805Digital Object Identifier
- Title
-
Angiotensin-Converting Enzyme 2 (ACE2) in the Context of Respiratory Diseases and Its Importance in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) InfectionWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-08-17Full publication date if available
- Authors
-
Enrique Ambrocio-Ortiz, Gloría Pérez-Rubio, Alma D. Del Ángel-Pablo, Ivette Buendía-Roldán, Leslie Chávez‐Galán, Rafael de Jesús Hernández-Zenteno, Alejandra Ramírez‐Venegas, Jorge Rojas‐Serrano, Mayra Mejía, Rogelio Pérez‐Padilla, Cristóbal Guadarrama-Pérez, Ramcés Falfán‐ValenciaList of authors in order
- Landing page
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https://doi.org/10.3390/ph14080805Publisher landing page
- PDF URL
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https://www.mdpi.com/1424-8247/14/8/805/pdf?version=1629266913Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1424-8247/14/8/805/pdf?version=1629266913Direct OA link when available
- Concepts
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Angiotensin-converting enzyme 2, Context (archaeology), Renin–angiotensin system, Medicine, Angiotensin II, Respiratory system, Coronavirus, Lung, Immunology, Severe acute respiratory syndrome, Biology, Internal medicine, Coronavirus disease 2019 (COVID-19), Disease, Blood pressure, Infectious disease (medical specialty), PaleontologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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7Total citation count in OpenAlex
- Citations by year (recent)
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2024: 1, 2023: 1, 2022: 4, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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105Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.severe | 98 |
| abstract_inverted_index.stress | 71 |
| abstract_inverted_index.system | 60 |
| abstract_inverted_index.(1–7) | 36, 53 |
| abstract_inverted_index.allowed | 138 |
| abstract_inverted_index.binding | 119 |
| abstract_inverted_index.context | 157 |
| abstract_inverted_index.current | 43 |
| abstract_inverted_index.encoded | 10 |
| abstract_inverted_index.enzyme. | 129 |
| abstract_inverted_index.general | 171 |
| abstract_inverted_index.injury, | 84 |
| abstract_inverted_index.located | 23 |
| abstract_inverted_index.picture | 144 |
| abstract_inverted_index.primary | 28 |
| abstract_inverted_index.produce | 34 |
| abstract_inverted_index.promote | 63 |
| abstract_inverted_index.protein | 9 |
| abstract_inverted_index.provide | 156 |
| abstract_inverted_index.regards | 166 |
| abstract_inverted_index.related | 145 |
| abstract_inverted_index.several | 135 |
| abstract_inverted_index.through | 121 |
| abstract_inverted_index.variety | 76 |
| abstract_inverted_index.various | 17 |
| abstract_inverted_index.clinical | 143, 172 |
| abstract_inverted_index.function | 29 |
| abstract_inverted_index.outbreak | 94 |
| abstract_inverted_index.proteins | 120 |
| abstract_inverted_index.research | 44 |
| abstract_inverted_index.revealed | 106 |
| abstract_inverted_index.specific | 124 |
| abstract_inverted_index.syndrome | 101 |
| abstract_inverted_index.described | 46 |
| abstract_inverted_index.diseases, | 78, 179 |
| abstract_inverted_index.diseases. | 182 |
| abstract_inverted_index.expressed | 15 |
| abstract_inverted_index.fibrosis, | 67 |
| abstract_inverted_index.functions | 160 |
| abstract_inverted_index.infection | 112, 148 |
| abstract_inverted_index.oxidative | 70 |
| abstract_inverted_index.processes | 72 |
| abstract_inverted_index.SARS-CoV-2 | 168 |
| abstract_inverted_index.cirrhosis, | 86 |
| abstract_inverted_index.epithelia. | 26 |
| abstract_inverted_index.especially | 20, 180 |
| abstract_inverted_index.expression | 133 |
| abstract_inverted_index.importance | 48, 108, 162 |
| abstract_inverted_index.understand | 141 |
| abstract_inverted_index.SARS-CoV-2. | 151 |
| abstract_inverted_index.alternative | 55 |
| abstract_inverted_index.angiotensin | 35, 38 |
| abstract_inverted_index.coronavirus | 102 |
| abstract_inverted_index.recognizing | 117 |
| abstract_inverted_index.respiratory | 100, 181 |
| abstract_inverted_index.(SARS-CoV-2) | 104 |
| abstract_inverted_index.interactions | 122 |
| abstract_inverted_index.Additionally, | 130 |
| abstract_inverted_index.hypertension, | 81 |
| abstract_inverted_index.inflammation, | 68 |
| abstract_inverted_index.Investigations | 90 |
| abstract_inverted_index.abnormalities. | 89 |
| abstract_inverted_index.downregulation | 65 |
| abstract_inverted_index.renin-angiotensin | 59 |
| abstract_inverted_index.Angiotensin-Converting | 0 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5007262185 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 12 |
| corresponding_institution_ids | https://openalex.org/I4210102695 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8600000143051147 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.66781965 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |