Animal Model Dependent Response to Pentagalloyl Glucose in Murine Abdominal Aortic Injury Article Swipe
Jennifer L. Anderson
,
Elizabeth E. Niedert
,
Sourav S. Patnaik
,
Renxiang Tang
,
Riley L. Holloway
,
Vangelina Osteguin
,
Ender A. Finol
,
Craig J. Goergen
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/jcm10020219
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/jcm10020219
Abdominal aortic aneurysms (AAAs) are a local dilation of the aorta and are associated with significant mortality due to rupture and treatment complications. There is a need for less invasive treatments to prevent aneurysm growth and rupture. In this study, we used two experimental murine models to evaluate the potential of pentagalloyl glucose (PGG), which is a polyphenolic tannin that binds to and crosslinks elastin and collagen, to preserve aortic compliance. Animals underwent surgical aortic injury and received 0.3% PGG or saline treatment on the adventitial surface of the infrarenal aorta. Seventeen mice underwent topical elastase injury, and 14 mice underwent topical calcium chloride injury. We collected high-frequency ultrasound images before surgery and at 3–4 timepoints after. There was no difference in the in vivo effective maximum diameter due to PGG treatment for either model. However, the CaCl2 model had significantly higher Green–Lagrange circumferential cyclic strain in PGG-treated animals (p < 0.05). While ex vivo pressure-inflation testing showed no difference between groups in either model, histology revealed reduced calcium deposits in the PGG treatment group with the CaCl2 model. These findings highlight the continued need for improved understanding of PGG’s effects on the extracellular matrix and suggest that PGG may reduce arterial calcium accumulation.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/jcm10020219
- https://www.mdpi.com/2077-0383/10/2/219/pdf?version=1610194388
- OA Status
- gold
- Cited By
- 7
- References
- 55
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3118580890
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3118580890Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/jcm10020219Digital Object Identifier
- Title
-
Animal Model Dependent Response to Pentagalloyl Glucose in Murine Abdominal Aortic InjuryWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-01-09Full publication date if available
- Authors
-
Jennifer L. Anderson, Elizabeth E. Niedert, Sourav S. Patnaik, Renxiang Tang, Riley L. Holloway, Vangelina Osteguin, Ender A. Finol, Craig J. GoergenList of authors in order
- Landing page
-
https://doi.org/10.3390/jcm10020219Publisher landing page
- PDF URL
-
https://www.mdpi.com/2077-0383/10/2/219/pdf?version=1610194388Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2077-0383/10/2/219/pdf?version=1610194388Direct OA link when available
- Concepts
-
Medicine, Elastin, Aorta, In vivo, Elastase, Calcium, Abdominal aortic aneurysm, Abdominal aorta, Saline, Anesthesia, Surgery, Cardiology, Internal medicine, Aneurysm, Pathology, Biochemistry, Enzyme, Chemistry, Biology, BiotechnologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
7Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2023: 1, 2022: 3, 2021: 2Per-year citation counts (last 5 years)
- References (count)
-
55Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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