Anopheles homing suppression drive candidates exhibit unexpected performance differences in simulations with spatial structure Article Swipe
Samuel E. Champer
,
Isabel K. Kim
,
Andrew G. Clark
,
Philipp W. Messer
,
Jackson Champer
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.7554/elife.79121
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.7554/elife.79121
Recent experiments have produced several Anopheles gambiae homing gene drives that disrupt female fertility genes, thereby eventually inducing population collapse. Such drives may be highly effective tools to combat malaria. One such homing drive, based on the zpg promoter driving CRISPR/Cas9, was able to eliminate a cage population of mosquitoes. A second version, purportedly improved upon the first by incorporating an X-shredder element (which biases inheritance towards male offspring), was similarly successful. Here, we analyze experimental data from each of these gene drives to extract their characteristics and performance parameters and compare these to previous interpretations of their experimental performance. We assess each suppression drive within an individual-based simulation framework that models mosquito population dynamics in continuous space. We find that the combined homing/X-shredder drive is actually less effective at population suppression within the context of our mosquito population model. In particular, the combined drive often fails to completely suppress the population, instead resulting in an unstable equilibrium between drive and wild-type alleles. By contrast, otherwise similar drives based on the nos promoter may prove to be more promising candidates for future development than originally thought.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.7554/elife.79121
- OA Status
- gold
- Cited By
- 38
- References
- 54
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4306174682
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4306174682Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.7554/elife.79121Digital Object Identifier
- Title
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Anopheles homing suppression drive candidates exhibit unexpected performance differences in simulations with spatial structureWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-10-14Full publication date if available
- Authors
-
Samuel E. Champer, Isabel K. Kim, Andrew G. Clark, Philipp W. Messer, Jackson ChamperList of authors in order
- Landing page
-
https://doi.org/10.7554/elife.79121Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.7554/elife.79121Direct OA link when available
- Concepts
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Gene drive, Anopheles gambiae, Population, Homing (biology), Biology, CRISPR, Context (archaeology), Metapopulation, Genetics, Malaria, Gene, Ecology, Biological dispersal, Immunology, Sociology, Demography, PaleontologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
38Total citation count in OpenAlex
- Citations by year (recent)
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2025: 12, 2024: 13, 2023: 9, 2022: 4Per-year citation counts (last 5 years)
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54Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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