Antagonistic effects of arginine methylation of LSM4 on alternative splicing during plant stress responses Article Swipe
Yamila C. Agrofoglio
,
Marı́a José Iglesias
,
Soledad Perez-Santángelo
,
María José de Leone
,
Tino Koester
,
Rafael Catalá
,
Julio Salinas
,
Marcelo J. Yanovsky
,
Dorothee Staiger
,
Julieta L. Mateos
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.12.08.570794
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.12.08.570794
Arabidopsis PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) post-translationally modifies RNA-binding proteins by arginine (R) methylation. The impact of this modification on the regulation of RNA processing is largely unknown. Here we use LSM4, a component of the spliceosome, as a paradigm to study the impact of R-methylation on its function in RNA processing. We identify in vivo targets of LSM4 and show that LSM4 regulates alternative splicing of a suite of them. Furthermore, LSM4 affects mRNA levels of some of the targets, showing for the first time its role in both AS and steady-state abundance. The lsm4 and prmt5 mutants show a considerable overlap of genes with altered splicing patterns, suggesting that these might be regulated by PRMT5-dependent LSM4 methylation. Wild-type LSM4 and an unmethylable version complement the lsm4-1 growth and circadian rhythms defects, suggesting that methylation is not critical for growth in normal environments. However, LSM4 methylation increases with ABA and is necessary for plants to respond properly to salt stress. In contrast, LSM4 methylation is reduced by bacterial infection, and plants expressing unmethylable LSM4 are more resistant than plants expressing wild-type LSM4. This tolerance correlates with decreased intron retention of immune-response genes upon infection, augmenting the functional isoform. Taken together, this provides the first direct evidence that R methylation adjusts LSM4 function on pre-mRNA splicing in an antagonistic manner in response to biotic and abiotic stress. Highlight Please provide a statement that, in fewer than 30 words, highlights the novelty of the paper for the non-expert . Arginine methylation of the LSM4 spliceosome component by PROTEIN ARGININE METHYLTRANSFERASE 5 fine-tunes alternative splicing of a set of stress-related genes to antagonistically control biotic and abiotic responses in Arabidopsis.
Related Topics
Concepts
Methylation
RNA splicing
Biology
Protein arginine methyltransferase 5
Alternative splicing
Epigenetics
RNA methylation
Spliceosome
DNA methylation
Methyltransferase
Cell biology
Intron
Genetics
RNA
Gene expression
Gene
Messenger RNA
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2023.12.08.570794
- https://www.biorxiv.org/content/biorxiv/early/2023/12/09/2023.12.08.570794.full.pdf
- OA Status
- green
- Cited By
- 1
- References
- 56
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4389514877
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4389514877Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2023.12.08.570794Digital Object Identifier
- Title
-
Antagonistic effects of arginine methylation of LSM4 on alternative splicing during plant stress responsesWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-12-09Full publication date if available
- Authors
-
Yamila C. Agrofoglio, Marı́a José Iglesias, Soledad Perez-Santángelo, María José de Leone, Tino Koester, Rafael Catalá, Julio Salinas, Marcelo J. Yanovsky, Dorothee Staiger, Julieta L. MateosList of authors in order
- Landing page
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https://doi.org/10.1101/2023.12.08.570794Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2023/12/09/2023.12.08.570794.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.biorxiv.org/content/biorxiv/early/2023/12/09/2023.12.08.570794.full.pdfDirect OA link when available
- Concepts
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Methylation, RNA splicing, Biology, Protein arginine methyltransferase 5, Alternative splicing, Epigenetics, RNA methylation, Spliceosome, DNA methylation, Methyltransferase, Cell biology, Intron, Genetics, RNA, Gene expression, Gene, Messenger RNATop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1Per-year citation counts (last 5 years)
- References (count)
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56Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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