Anti-adipogenic activity of 4,5,4'-trihydroxy-3,3'-dimethoxybibenzyl from dendrobium ellipsophyllum in 3t3-l1 preadipocytes Article Swipe
Obesity and its global prevalence have become a threat to human health due to not only�the abnormal lipid accumulation in the body as a result of aberrant expression levels in adipocyte differentiation and lipogenesis but also the underdeveloped pharmacotherapy. Recently, the bioactive compounds from the natural products have gained a lot of attention due to undertaking prophylactic and therapeutic effects on obesity. Here, we probed how 4,5,4?-trihydroxy-3,3?-dimethoxybibenzyl (TDB) extracted�from an Thai orchid (Dendrobium ellipsophyllum) could exert its roles on the differentiation and function of murine (3T3-L1) and human (PCS-210-010) preadipocytes�and offer some implications to modulate obesity. Cytotoxic effects of TDB on preadipocytes (Half maximum inhibitory concentration; IC50 = ~36 ?M) were two-fold higher than those detected on adipocytes (IC50 = ~72 ?M), and no significant difference was detected in cytotoxic profiles between both cells. TDB in a dose-dependent manner decreased cellular lipid accumulation and enhanced lipolysis of both cell lines assessed at early differentiation and during maturation. Underlining molecular mechanisms proved that TDB�paused the cell cycle progression by regulating inducers and inhibitors in mitotic clonal expansion, leading to growth arrest of preadipocytes at the G0/G1 phase. The compound also governed adipocyte differentiation by repressing expressions of crucial adipogenic regulators and effectors through deactivating the AKT/GSK-3? signaling pathway and activating the AMPK-ACC pathway. To this end, TDB has shown its pharmaceutical potential for modulating adipocyte development and function, and it would be a promising candidate for further assessments as a therapeutic agent to defeat obesity.
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Metadata
- Type
- dissertation
- Language
- en
- Landing Page
- https://doi.org/10.58837/chula.the.2022.289
- OA Status
- gold
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4386787921
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4386787921Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.58837/chula.the.2022.289Digital Object Identifier
- Title
-
Anti-adipogenic activity of 4,5,4'-trihydroxy-3,3'-dimethoxybibenzyl from dendrobium ellipsophyllum in 3t3-l1 preadipocytesWork title
- Type
-
dissertationOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-01-01Full publication date if available
- Authors
-
Hnin KhineList of authors in order
- Landing page
-
https://doi.org/10.58837/chula.the.2022.289Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.58837/chula.the.2022.289Direct OA link when available
- Concepts
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Adipogenesis, Lipogenesis, Adipocyte, 3T3-L1, Cell biology, Lipolysis, Cell growth, Lipid droplet, Endocrinology, Biology, Chemistry, Internal medicine, Cell cycle, Pharmacology, Adipose tissue, Cancer research, Cell, Biochemistry, MedicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.TDB�paused | 162 |
| abstract_inverted_index.accumulation | 18, 142 |
| abstract_inverted_index.deactivating | 202 |
| abstract_inverted_index.implications | 92 |
| abstract_inverted_index.prophylactic | 56 |
| abstract_inverted_index.(PCS-210-010) | 88 |
| abstract_inverted_index.preadipocytes | 101, 181 |
| abstract_inverted_index.concentration; | 105 |
| abstract_inverted_index.dose-dependent | 137 |
| abstract_inverted_index.pharmaceutical | 219 |
| abstract_inverted_index.underdeveloped | 37 |
| abstract_inverted_index.differentiation | 31, 80, 153, 191 |
| abstract_inverted_index.ellipsophyllum) | 73 |
| abstract_inverted_index.extracted�from | 68 |
| abstract_inverted_index.pharmacotherapy. | 38 |
| abstract_inverted_index.preadipocytes�and | 89 |
| abstract_inverted_index.4,5,4?-trihydroxy-3,3?-dimethoxybibenzyl | 66 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5014996904 |
| countries_distinct_count | 0 |
| institutions_distinct_count | 1 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.5600000023841858 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile |