Anti-CD19 CAR-T Therapy for Central Lymphoma: A Case Study of Ocular Follicular Lymphoma and Emerging Therapeutic Strategies Article Swipe
Hui Li
,
Ping Long
,
Xinyu Wei
,
Meng Zhou
,
Ming Xuan
,
Haichuan Zhu
,
Ming Zhu
,
Lei Feng
,
Ming Li
,
Qin Wu
,
Tongcun Zhang
,
Yi Xiao
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-6369375/v1
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-6369375/v1
Background: Central lymphomas, including rare and anatomically complex subtypes such as ocular follicular lymphoma (OFL), pose substantial therapeutic challenges due to their localization and unique microenvironment promoting immune evasion. OFL, a rare manifestation of follicular lymphoma (FL), often exhibits resistance to standard therapies, necessitating innovative approaches. Methods: This case report highlights the application of anti-CD19 CAR-T therapy in a patient with OFL. Treatment outcomes, including safety, cytokine release syndrome (CRS), and durability of remission, were assessed during an 18-month follow-up. Results: The patient achieved complete metabolic remission with no evidence of systemic relapse or significant long-term toxicities. Transient grade 1–2 CRS was observed but resolved with supportive care. No neurological toxicities were reported, and the patient has remained disease-free. Conclusions: Anti-CD19 CAR-T therapy demonstrated sustained efficacy and a favorable safety profile in this case of OFL, underscoring its potential as an innovative therapeutic approach for central lymphomas. Further research is warranted to explore its integration into first-line treatment settings and optimize its applicability across broader lymphoma subtypes.
Related Topics
Concepts
Follicular lymphoma
Medicine
Lymphoma
Oncology
Internal medicine
Cytokine release syndrome
Therapeutic approach
Follicular phase
Immune system
Disease
Immunology
Immunotherapy
Chimeric antigen receptor
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-6369375/v1
- https://www.researchsquare.com/article/rs-6369375/latest.pdf
- OA Status
- gold
- References
- 19
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411895185
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4411895185Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-6369375/v1Digital Object Identifier
- Title
-
Anti-CD19 CAR-T Therapy for Central Lymphoma: A Case Study of Ocular Follicular Lymphoma and Emerging Therapeutic StrategiesWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-07-01Full publication date if available
- Authors
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Hui Li, Ping Long, Xinyu Wei, Meng Zhou, Ming Xuan, Haichuan Zhu, Ming Zhu, Lei Feng, Ming Li, Qin Wu, Tongcun Zhang, Yi XiaoList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-6369375/v1Publisher landing page
- PDF URL
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https://www.researchsquare.com/article/rs-6369375/latest.pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://www.researchsquare.com/article/rs-6369375/latest.pdfDirect OA link when available
- Concepts
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Follicular lymphoma, Medicine, Lymphoma, Oncology, Internal medicine, Cytokine release syndrome, Therapeutic approach, Follicular phase, Immune system, Disease, Immunology, Immunotherapy, Chimeric antigen receptorTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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19Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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