Introduction: One of the primary goals of root canal therapy is to relieve the discomfort associated with permanently injured pulps.Root canal therapy is the sole option for saving a tooth with irreversible pulpitis.Nonsteroidal anti-inflammatory medications can be used to treat inflammation (NSAIDs).All NSAIDs have the potential to induce severe adverse effects such as stomach ulcers, gastrointestinal bleeding, renal failure, heart attacks, and strokes.The aim of this study is to evaluate the anti-inflammatory ac…