Anti-Inflammatory Effects of a Novel Acetonitrile–Water Extract of Lens Culinaris against LPS-Induced Damage in Caco-2 Cells Article Swipe
Fatima Maqoud
,
Antonella Orlando
,
Domenico Tricarico
,
Marina Antonacci
,
Annamaria Di Turi
,
Gianluigi Giannelli
,
Francesco Russo
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/ijms25073802
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/ijms25073802
Natural compounds like flavonoids preserve intestinal mucosal integrity through their antioxidant, anti-inflammatory, and antimicrobial properties. Additionally, some flavonoids show prebiotic abilities, promoting the growth and activity of beneficial gut bacteria. This study investigates the protective impact of Lens culinaris extract (LE), which is abundant in flavonoids, on intestinal mucosal integrity during LPS-induced inflammation. Using Caco-2 cells as a model for the intestinal barrier, the study found that LE did not affect cell viability but played a cytoprotective role in the presence of LPS. LE improved transepithelial electrical resistance (TEER) and tight junction (TJ) protein levels, which are crucial for barrier integrity. It also countered the upregulation of pro-inflammatory genes TRPA1 and TRPV1 induced by LPS and reduced pro-inflammatory markers like TNF-α, NF-κB, IL-1β, and IL-8. Moreover, LE reversed the LPS-induced upregulation of AQP8 and TLR-4 expression. These findings emphasize the potential of natural compounds like LE to regulate the intestinal barrier and reduce inflammation’s harmful effects on intestinal cells. More research is required to understand their mechanisms and explore therapeutic applications, especially for gastrointestinal inflammatory conditions.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms25073802
- https://www.mdpi.com/1422-0067/25/7/3802/pdf?version=1711643684
- OA Status
- gold
- Cited By
- 4
- References
- 44
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4393279044
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4393279044Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ijms25073802Digital Object Identifier
- Title
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Anti-Inflammatory Effects of a Novel Acetonitrile–Water Extract of Lens Culinaris against LPS-Induced Damage in Caco-2 CellsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-03-28Full publication date if available
- Authors
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Fatima Maqoud, Antonella Orlando, Domenico Tricarico, Marina Antonacci, Annamaria Di Turi, Gianluigi Giannelli, Francesco RussoList of authors in order
- Landing page
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https://doi.org/10.3390/ijms25073802Publisher landing page
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https://www.mdpi.com/1422-0067/25/7/3802/pdf?version=1711643684Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1422-0067/25/7/3802/pdf?version=1711643684Direct OA link when available
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Caco-2, Chemistry, Lens (geology), Acetonitrile, Inflammation, Biochemistry, Biology, Immunology, In vitro, Chromatography, PaleontologyTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2025: 2, 2024: 2Per-year citation counts (last 5 years)
- References (count)
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44Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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