Anti-schistosomal immunity to core xylose/fucose in N-glycans Article Swipe
Nina Salinger Prasanphanich
,
Kristoffer E. Leon
,
W. Evan Secor
,
Charles B. Shoemaker
,
Jamie Heimburg‐Molinaro
,
Richard D. Cummings
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fmolb.2023.1142620
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fmolb.2023.1142620
Schistosomiasis is a globally prevalent, debilitating disease that is poorly controlled by chemotherapy and for which no vaccine exists. While partial resistance in people may develop over time with repeated infections and treatments, some animals, including the brown rat ( Rattus norvegicus ), are only semi-permissive and have natural protection. To understand the basis of this protection, we explored the nature of the immune response in the brown rat to infection by Schistosoma mansoni . Infection leads to production of IgG to parasite glycoproteins with complex-type N-glycans that contain a non-mammalian-type modification by core α2-Xylose and core α3-Fucose (core Xyl/Fuc). These epitopes are expressed on the surfaces of schistosomula and adult worms. Importantly, IgG to these epitopes can kill schistosomula by a complement-dependent process in vitro . Additionally, sera from both infected rhesus monkey and infected brown rat were capable of killing schistosomula in a manner inhibited by glycopeptides containing core Xyl/Fuc. These results demonstrate that protective antibodies to schistosome infections in brown rats and rhesus monkeys include IgG responses to the core Xyl/Fuc epitopes in surface-expressed N-glycans, and raise the potential of novel glyco-based vaccines that might be developed to combat this disease.
Related Topics
Concepts
Epitope
Fucose
Biology
Schistosoma mansoni
Glycan
Schistosomiasis
Immune system
Immunology
Antibody
Virology
Glycoprotein
Schistosoma
Immunity
In vitro
Microbiology
Helminths
Molecular biology
Biochemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fmolb.2023.1142620
- https://www.frontiersin.org/articles/10.3389/fmolb.2023.1142620/pdf
- OA Status
- gold
- Cited By
- 10
- References
- 122
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4362561328
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4362561328Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fmolb.2023.1142620Digital Object Identifier
- Title
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Anti-schistosomal immunity to core xylose/fucose in N-glycansWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-04-04Full publication date if available
- Authors
-
Nina Salinger Prasanphanich, Kristoffer E. Leon, W. Evan Secor, Charles B. Shoemaker, Jamie Heimburg‐Molinaro, Richard D. CummingsList of authors in order
- Landing page
-
https://doi.org/10.3389/fmolb.2023.1142620Publisher landing page
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https://www.frontiersin.org/articles/10.3389/fmolb.2023.1142620/pdfDirect link to full text PDF
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fmolb.2023.1142620/pdfDirect OA link when available
- Concepts
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Epitope, Fucose, Biology, Schistosoma mansoni, Glycan, Schistosomiasis, Immune system, Immunology, Antibody, Virology, Glycoprotein, Schistosoma, Immunity, In vitro, Microbiology, Helminths, Molecular biology, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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10Total citation count in OpenAlex
- Citations by year (recent)
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2025: 5, 2024: 3, 2023: 2Per-year citation counts (last 5 years)
- References (count)
-
122Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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