Anti-Sp4 and anti-CCAR1 autoantibodies in UK vs US patients with adult and juvenile-onset anti-TIF1γ-positive myositis Article Swipe

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Fionnuala K McMorrow , Lucy R. Wedderburn , Hector Chinoy , Alexander Oldroyd , Janine A. Lamb , Lisa G. Rider , Andrew L. Mammen , Livia Casciola‐Rosen , Neil McHugh , Sarah Tansley , Kate Armon , Louise Coke , Julie Cook , Amy Nichols , Liza McCann , Ian Roberts , Eileen Baildam , Louise Hanna , Olivia Lloyd , Susan Wadeson , Michelle Andrews , Olivia Lloyd , Jane Roach , Phil Riley , Ann McGovern , Verna Cuthbert , Clive Ryder , J Scott , Beverley Thomas , T. R. E. Southwood , Eslam Al-Abadi , Ruth Howman , Sue Wyatt , Gillian Jackson , Mark Wood , Tania Amin , Vanessa VanRooyen , Deborah Burton , Louise Turner , Heather Rostron , Sarah Hanson , Joyce Davidson , Janet Gardner‐Medwin , Neil A. Martin , Sue A. Ferguson , Liz Waxman , Michael Browne , Roisin Boyle , Emily Blyth , Susanne Cathcart , Mark Friswell , Helen Foster , Andrew C. Swift , Sharmila Jandial , V. Stevenson , Debbie Wade , Ethan S Sen , Eve Smith , Liang Qiao , Stuart Watson , Claire Duong , Stephen Crulley , Andrew J. Davies , Miss Caroline Miller , Lynne Bell , Flora McErlane , Sunil Sampath , Josh Bennet , Sharon King , H Venning , Satyapal Rangaraj , Elizabeth Stretton , Mary Jordan , Ellen Mosley , Adaani Frost , Lindsay Crate , Kishore Warrier , Stefanie Stafford , Brogan Wrest , Chia-Ping Chou , Paul Pryce , Lucy R. Wedderburn , Clarissa Pilkington , Nathan Hasson , Muthana Al-Obadi , Giulia Varnier , Sandrine Lacassagne , Sue Maillard , Lauren E. Stone , Elizabeth Halkon , Virginia Brown , Audrey Juggins , Sally A. Smith , Sian Lunt , Elli Enayat , Hemlata Varsani , Laura Kassoumeri , Mary A. Beard , Katie Arnold , Yvonne Glackin ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.1093/rheumatology/keae574

Objectives Anti-transcriptional intermediary factor 1γ (TIF1γ) autoantibodies are associated with malignancy in adult-onset idiopathic inflammatory myopathy (IIM) and this risk is attenuated if patients are also positive for anti-specificity protein 4 (Sp4) or anti-cell division cycle apoptosis regulator protein 1 (CCAR1). In anti-TIF1γ positive dermatomyositis (DM) patients from the USA, anti-Sp4 and anti-CCAR1 autoantibody frequencies are reported as 32% and 43% in adults and 9% and 19% in juveniles, respectively. This study aims to identify the frequency of anti-Sp4 and anti-CCAR1 in adult and juvenile UK anti-TIF1γ-positive myositis populations and report clinical associations. Methods Serum samples from 51 UK participants with adult-onset IIM and 55 UK participants with JDM, all anti-TIF1γ autoantibody positive, and 24 healthy control samples were screened for anti-Sp4 and anti-CCAR1 autoantibodies by ELISA. Results In UK adult anti-TIF1γ positive IIM patients, anti-Sp4 and anti-CCAR1 frequencies were 4% (2/51) and 16% (8/51). Both adult patients with anti-Sp4 were also positive for anti-CCAR1. In UK juveniles, anti-Sp4 was not detected and 13% (7/55) had anti-CCAR1 autoantibodies. Nineteen (37%) anti-TIF1γ positive UK adult myositis patients had cancer; neither of the two patients with anti-Sp4 autoantibodies and 25% (2/8) of anti-CCAR1 autoantibody-positive patients had cancer. No anti-Sp4 or anti-CCAR1 clinical associations were identified. Conclusion Anti-Sp4 and anti-CCAR1 autoantibodies are less common in the adult UK anti-TIF1γ-positive myositis population compared with published data from the USA, limiting their use as biomarkers for cancer risk. In patients with juvenile onset disease, anti-Sp4 is less frequent in UK patients compared with the USA, but the prevalence of anti-CCAR1 autoantibodies is similar.

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Medicine Autoantibody Juvenile Myositis Internal medicine Antibody Immunology Genetics Biology

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Type: article
Language: en
Landing Page: https://doi.org/10.1093/rheumatology/keae574
PDF: https://academic.oup.com/rheumatology/advance-article-pdf/doi/10.1093/rheumatology/keae574/60542068/keae574.pdf
OA Status: hybrid
Cited By: 1
References: 20
Related Works: 10
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DOI: https://doi.org/10.1093/rheumatology/keae574

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Title: Anti-Sp4 and anti-CCAR1 autoantibodies in UK vs US patients with adult and juvenile-onset anti-TIF1γ-positive myositis

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Language: en

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Publication year: 2024

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Publication date: 2024-11-07

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Authors: Fionnuala K McMorrow, Lucy R. Wedderburn, Hector Chinoy, Alexander Oldroyd, Janine A. Lamb, Lisa G. Rider, Andrew L. Mammen, Livia Casciola‐Rosen, Neil McHugh, Sarah Tansley, Kate Armon, Louise Coke, Julie Cook, Amy Nichols, Liza McCann, Ian Roberts, Eileen Baildam, Louise Hanna, Olivia Lloyd, Susan Wadeson, Michelle Andrews, Olivia Lloyd, Jane Roach, Phil Riley, Ann McGovern, Verna Cuthbert, Clive Ryder, J Scott, Beverley Thomas, T. R. E. Southwood, Eslam Al-Abadi, Ruth Howman, Sue Wyatt, Gillian Jackson, Mark Wood, Tania Amin, Vanessa VanRooyen, Deborah Burton, Louise Turner, Heather Rostron, Sarah Hanson, Joyce Davidson, Janet Gardner‐Medwin, Neil A. Martin, Sue A. Ferguson, Liz Waxman, Michael Browne, Roisin Boyle, Emily Blyth, Susanne Cathcart, Mark Friswell, Helen Foster, Andrew C. Swift, Sharmila Jandial, V. Stevenson, Debbie Wade, Ethan S Sen, Eve Smith, Liang Qiao, Stuart Watson, Claire Duong, Stephen Crulley, Andrew J. Davies, Miss Caroline Miller, Lynne Bell, Flora McErlane, Sunil Sampath, Josh Bennet, Sharon King, H Venning, Satyapal Rangaraj, Elizabeth Stretton, Mary Jordan, Ellen Mosley, Adaani Frost, Lindsay Crate, Kishore Warrier, Stefanie Stafford, Brogan Wrest, Chia-Ping Chou, Paul Pryce, Lucy R. Wedderburn, Clarissa Pilkington, Nathan Hasson, Muthana Al-Obadi, Giulia Varnier, Sandrine Lacassagne, Sue Maillard, Lauren E. Stone, Elizabeth Halkon, Virginia Brown, Audrey Juggins, Sally A. Smith, Sian Lunt, Elli Enayat, Hemlata Varsani, Laura Kassoumeri, Mary A. Beard, Katie Arnold, Yvonne Glackin

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Landing page: https://doi.org/10.1093/rheumatology/keae574

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Concepts: Medicine, Autoantibody, Juvenile, Myositis, Internal medicine, Antibody, Immunology, Genetics, Biology

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Cited by: 1

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