Anti-TNF Therapies Suppress Adipose Tissue Inflammation in Crohn’s Disease Article Swipe
A Boronat-Toscano
,
Diandra Monfort-Ferré
,
Margarita Menacho
,
Aleidis Caro
,
Ramón Bosch
,
Beatriz Espina
,
Francisco Algaba‐Chueca
,
Alfonso Saera-Vila
,
Alicia Moliné
,
Marc Martí
,
Eloy Espín
,
Mónica Millán
,
Carolina Serena
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/ijms231911170
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/ijms231911170
Anti-TNF biologics have been shown to markedly improve the quality of life for patients with Crohn’s disease (CD), yet one-third of patients fail to benefit from this treatment. Patients with CD develop a characteristic wrapping of visceral adipose tissue (VAT) in the inflamed intestinal area, termed creeping fat, and it is known that adipose tissue expansion influences the efficacy of anti-TNF drugs. We questioned whether anti-TNF therapies impact the creeping fat in CD, which might affect the outcome of the disease. Adipose tissue biopsies were obtained from a cohort of 14 patients with CD that received anti-TNF drugs and from 29 non-anti-TNF-treated patients (control group) matched by sex, age, and body mass index undergoing surgical interventions for symptomatic complications. We found that anti-TNF therapies restored adipose tissue morphology and suppressed immune cell infiltration in the creeping fat. Additionally, anti-TNF treatments appeared to markedly improve the pro-inflammatory phenotype of adipose-tissue macrophages and adipose-tissue-derived stem cells. Our study provides evidence that anti-TNF medications influence immune cells and progenitor cells in the creeping of patients with CD, suppressing inflammation. We propose that perilesional VAT should be considered when administering anti-TNF therapy in patients with CD.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms231911170
- https://www.mdpi.com/1422-0067/23/19/11170/pdf?version=1663851148
- OA Status
- gold
- Cited By
- 8
- References
- 57
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4296993268
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4296993268Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ijms231911170Digital Object Identifier
- Title
-
Anti-TNF Therapies Suppress Adipose Tissue Inflammation in Crohn’s DiseaseWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-09-22Full publication date if available
- Authors
-
A Boronat-Toscano, Diandra Monfort-Ferré, Margarita Menacho, Aleidis Caro, Ramón Bosch, Beatriz Espina, Francisco Algaba‐Chueca, Alfonso Saera-Vila, Alicia Moliné, Marc Martí, Eloy Espín, Mónica Millán, Carolina SerenaList of authors in order
- Landing page
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https://doi.org/10.3390/ijms231911170Publisher landing page
- PDF URL
-
https://www.mdpi.com/1422-0067/23/19/11170/pdf?version=1663851148Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1422-0067/23/19/11170/pdf?version=1663851148Direct OA link when available
- Concepts
-
Adipose tissue, Medicine, Inflammation, Tumor necrosis factor alpha, Immune system, Disease, Internal medicine, Immunology, Pathology, GastroenterologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
8Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 3, 2023: 2Per-year citation counts (last 5 years)
- References (count)
-
57Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.cells | 163, 166 |
| abstract_inverted_index.drugs | 97 |
| abstract_inverted_index.found | 120 |
| abstract_inverted_index.index | 112 |
| abstract_inverted_index.known | 51 |
| abstract_inverted_index.might | 74 |
| abstract_inverted_index.shown | 4 |
| abstract_inverted_index.study | 155 |
| abstract_inverted_index.which | 73 |
| abstract_inverted_index.affect | 75 |
| abstract_inverted_index.cells. | 153 |
| abstract_inverted_index.cohort | 88 |
| abstract_inverted_index.drugs. | 61 |
| abstract_inverted_index.group) | 104 |
| abstract_inverted_index.immune | 130, 162 |
| abstract_inverted_index.impact | 67 |
| abstract_inverted_index.should | 181 |
| abstract_inverted_index.termed | 45 |
| abstract_inverted_index.tissue | 38, 54, 82, 126 |
| abstract_inverted_index.Adipose | 81 |
| abstract_inverted_index.adipose | 37, 53, 125 |
| abstract_inverted_index.benefit | 24 |
| abstract_inverted_index.develop | 31 |
| abstract_inverted_index.disease | 16 |
| abstract_inverted_index.improve | 7, 143 |
| abstract_inverted_index.matched | 105 |
| abstract_inverted_index.outcome | 77 |
| abstract_inverted_index.propose | 177 |
| abstract_inverted_index.quality | 9 |
| abstract_inverted_index.therapy | 187 |
| abstract_inverted_index.whether | 64 |
| abstract_inverted_index.(control | 103 |
| abstract_inverted_index.Anti-TNF | 0 |
| abstract_inverted_index.Patients | 28 |
| abstract_inverted_index.anti-TNF | 60, 65, 96, 122, 138, 159, 186 |
| abstract_inverted_index.appeared | 140 |
| abstract_inverted_index.biopsies | 83 |
| abstract_inverted_index.creeping | 46, 69, 135, 169 |
| abstract_inverted_index.disease. | 80 |
| abstract_inverted_index.efficacy | 58 |
| abstract_inverted_index.evidence | 157 |
| abstract_inverted_index.inflamed | 42 |
| abstract_inverted_index.markedly | 6, 142 |
| abstract_inverted_index.obtained | 85 |
| abstract_inverted_index.patients | 13, 21, 91, 102, 171, 189 |
| abstract_inverted_index.provides | 156 |
| abstract_inverted_index.received | 95 |
| abstract_inverted_index.restored | 124 |
| abstract_inverted_index.surgical | 114 |
| abstract_inverted_index.visceral | 36 |
| abstract_inverted_index.wrapping | 34 |
| abstract_inverted_index.Crohn’s | 15 |
| abstract_inverted_index.biologics | 1 |
| abstract_inverted_index.expansion | 55 |
| abstract_inverted_index.influence | 161 |
| abstract_inverted_index.one-third | 19 |
| abstract_inverted_index.phenotype | 146 |
| abstract_inverted_index.therapies | 66, 123 |
| abstract_inverted_index.considered | 183 |
| abstract_inverted_index.influences | 56 |
| abstract_inverted_index.intestinal | 43 |
| abstract_inverted_index.morphology | 127 |
| abstract_inverted_index.progenitor | 165 |
| abstract_inverted_index.questioned | 63 |
| abstract_inverted_index.suppressed | 129 |
| abstract_inverted_index.treatment. | 27 |
| abstract_inverted_index.treatments | 139 |
| abstract_inverted_index.undergoing | 113 |
| abstract_inverted_index.macrophages | 149 |
| abstract_inverted_index.medications | 160 |
| abstract_inverted_index.suppressing | 174 |
| abstract_inverted_index.symptomatic | 117 |
| abstract_inverted_index.infiltration | 132 |
| abstract_inverted_index.perilesional | 179 |
| abstract_inverted_index.Additionally, | 137 |
| abstract_inverted_index.administering | 185 |
| abstract_inverted_index.inflammation. | 175 |
| abstract_inverted_index.interventions | 115 |
| abstract_inverted_index.adipose-tissue | 148 |
| abstract_inverted_index.characteristic | 33 |
| abstract_inverted_index.complications. | 118 |
| abstract_inverted_index.pro-inflammatory | 145 |
| abstract_inverted_index.non-anti-TNF-treated | 101 |
| abstract_inverted_index.adipose-tissue-derived | 151 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5002248518 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 13 |
| corresponding_institution_ids | https://openalex.org/I4210101772, https://openalex.org/I55952717 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6000000238418579 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.83938252 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |