Anti-TSLP Drug Article Swipe

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Mizuho Nagao ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.3388/jspaci.38.225

Thymic stromal lymphopoietin(TSLP)は,上皮細胞由来のサイトカインであり,自然免疫および獲得免疫の経路を介して2型炎症の誘導に重要な役割を果たす.テゼペルマブは,TSLPがTSLP受容体に結合するのを阻害するヒトIgG2モノクローナル抗体であり,喘息の新しい生物学的製剤である.テゼペルマブの喘息における有効性と作用機序を評価するために,PATHWAY,NAVIGATOR,NOZOMI,UPSTREAM,CASCADE,SOURCE,DESTINATIONなどといったいくつかの臨床試験が実施されている.これらの結果は,テゼペルマブが幅広いターゲットの生物学的製剤であり,表現型に関係なく吸入ステロイド(ICS)ではコントロール困難な喘息患者に有効であることが期待されているが,テゼペルマブの作用機序や非2型表現型の患者における有効性,経口ステロイド依存性喘息への影響などはまだ不明であり,さらなる研究が必要である.小児の喘息治療における生物学的製剤の選択はまだ確立されておらず,患者の病態に応じた適切な治療法の選択ができるよう検討が必要である.

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Landing Page: https://doi.org/10.3388/jspaci.38.225
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DOI: https://doi.org/10.3388/jspaci.38.225

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Title: Anti-TSLP Drug

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Type: article

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Language: en

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Publication year: 2024

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Publication date: 2024-06-19

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Authors: Mizuho Nagao

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Landing page: https://doi.org/10.3388/jspaci.38.225

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Cited by: 0

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abstract_inverted_index.lymphopoietin(TSLP)は,上皮細胞由来のサイトカインであり,自然免疫および獲得免疫の経路を介して2型炎症の誘導に重要な役割を果たす.テゼペルマブは,TSLPがTSLP受容体に結合するのを阻害するヒトIgG2モノクローナル抗体であり,喘息の新しい生物学的製剤である.テゼペルマブの喘息における有効性と作用機序を評価するために,PATHWAY,NAVIGATOR,NOZOMI,UPSTREAM,CASCADE,SOURCE,DESTINATIONなどといったいくつかの臨床試験が実施されている.これらの結果は,テゼペルマブが幅広いターゲットの生物学的製剤であり,表現型に関係なく吸入ステロイド(ICS)ではコントロール困難な喘息患者に有効であることが期待されているが,テゼペルマブの作用機序や非2型表現型の患者における有効性,経口ステロイド依存性喘息への影響などはまだ不明であり,さらなる研究が必要である.小児の喘息治療における生物学的製剤の選択はまだ確立されておらず,患者の病態に応じた適切な治療法の選択ができるよう検討が必要である.	2
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