Antibacterial Evaluation of Sophoraflavanone G from Sophora pachycarpa Against Pseudomonas aeruginosa and Staphylococcus epidermidis Biofilm Article Swipe
Niloofar Zanganeh
,
Ghazaleh Hatamian
,
Abolfazl Shakeri
,
BiBi Sedigheh Fazly Bazzaz
,
Milad Iranshahy
,
Vahid Soheili
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-7299693/v1
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-7299693/v1
Antimicrobial resistance, particularly among biofilm-forming pathogens, poses a serious threat to public health and drives the urgent need for new therapeutic agents. Sophoraflavanone G, a prenylated flavonoid derived from Sophora pachycarpa , has shown notable antimicrobial activity, especially against Gram-positive bacteria. In this study, Sophoraflavanone G was isolated and purified using chromatographic techniques and structurally confirmed via ¹H-NMR. Its antibacterial and anti-biofilm properties were evaluated against several bacterial strains, including Pseudomonas aeruginosa PAO1 and Staphylococcus epidermidis DSMZ 3270. The compound exhibited potent inhibitory and bactericidal activity against all tested Gram-positive bacteria, with Listeria monocytogenes being the most sensitive (MIC = 0.98 µg/mL). However, it showed no activity against P. aeruginosa in planktonic form (MIC > 1000 µg/mL). While it failed to inhibit P. aeruginosa biofilm formation or enhance tobramycin penetration at low doses, a higher concentration (1 mg/mL) of Sophoraflavanone G significantly improved antibiotic penetration into the biofilm. In contrast, the compound demonstrated strong inhibitory, disruptive, and biofilm-penetrating effects against S. epidermidis , with a clear dose-dependent response. These findings underscore the potential of Sophoraflavanone G as a candidate for managing Gram-positive and biofilm-associated infections, particularly those involving S. epidermidis , while highlighting the need for further development to improve its efficacy against Gram-negative pathogens.
Related Topics
Concepts
Pseudomonas aeruginosa
Biofilm
Antimicrobial
Chemistry
Staphylococcus epidermidis
Microbiology
Staphylococcus aureus
Antibiotics
Minimum inhibitory concentration
Sophora flavescens
Tobramycin
Sophora
Antibacterial activity
Penetration (warfare)
Flavonoid
Bacteria
Antibiotic resistance
Antibacterial agent
In vitro
Metadata
- Type
- article
- Landing Page
- https://doi.org/10.21203/rs.3.rs-7299693/v1
- https://www.researchsquare.com/article/rs-7299693/latest.pdf
- OA Status
- gold
- References
- 25
- OpenAlex ID
- https://openalex.org/W7106635087
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W7106635087Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21203/rs.3.rs-7299693/v1Digital Object Identifier
- Title
-
Antibacterial Evaluation of Sophoraflavanone G from Sophora pachycarpa Against Pseudomonas aeruginosa and Staphylococcus epidermidis BiofilmWork title
- Type
-
articleOpenAlex work type
- Publication year
-
2025Year of publication
- Publication date
-
2025-11-25Full publication date if available
- Authors
-
Niloofar Zanganeh, Ghazaleh Hatamian, Abolfazl Shakeri, BiBi Sedigheh Fazly Bazzaz, Milad Iranshahy, Vahid SoheiliList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-7299693/v1Publisher landing page
- PDF URL
-
https://www.researchsquare.com/article/rs-7299693/latest.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
- OA URL
-
https://www.researchsquare.com/article/rs-7299693/latest.pdfDirect OA link when available
- Concepts
-
Pseudomonas aeruginosa, Biofilm, Antimicrobial, Chemistry, Staphylococcus epidermidis, Microbiology, Staphylococcus aureus, Antibiotics, Minimum inhibitory concentration, Sophora flavescens, Tobramycin, Sophora, Antibacterial activity, Penetration (warfare), Flavonoid, Bacteria, Antibiotic resistance, Antibacterial agent, In vitroTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
25Number of works referenced by this work
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| abstract_inverted_index.higher | 135 |
| abstract_inverted_index.mg/mL) | 138 |
| abstract_inverted_index.potent | 82 |
| abstract_inverted_index.public | 12 |
| abstract_inverted_index.showed | 105 |
| abstract_inverted_index.strong | 154 |
| abstract_inverted_index.study, | 44 |
| abstract_inverted_index.tested | 89 |
| abstract_inverted_index.threat | 10 |
| abstract_inverted_index.urgent | 17 |
| abstract_inverted_index.against | 39, 66, 87, 108, 160, 203 |
| abstract_inverted_index.agents. | 22 |
| abstract_inverted_index.biofilm | 125 |
| abstract_inverted_index.derived | 28 |
| abstract_inverted_index.effects | 159 |
| abstract_inverted_index.enhance | 128 |
| abstract_inverted_index.further | 197 |
| abstract_inverted_index.improve | 200 |
| abstract_inverted_index.inhibit | 122 |
| abstract_inverted_index.notable | 35 |
| abstract_inverted_index.serious | 9 |
| abstract_inverted_index.several | 67 |
| abstract_inverted_index.However, | 103 |
| abstract_inverted_index.activity | 86, 107 |
| abstract_inverted_index.biofilm. | 148 |
| abstract_inverted_index.compound | 80, 152 |
| abstract_inverted_index.efficacy | 202 |
| abstract_inverted_index.findings | 170 |
| abstract_inverted_index.improved | 143 |
| abstract_inverted_index.isolated | 48 |
| abstract_inverted_index.managing | 181 |
| abstract_inverted_index.purified | 50 |
| abstract_inverted_index.strains, | 69 |
| abstract_inverted_index.µg/mL). | 102, 117 |
| abstract_inverted_index.¹H-NMR. | 58 |
| abstract_inverted_index.activity, | 37 |
| abstract_inverted_index.bacteria, | 91 |
| abstract_inverted_index.bacteria. | 41 |
| abstract_inverted_index.bacterial | 68 |
| abstract_inverted_index.candidate | 179 |
| abstract_inverted_index.confirmed | 56 |
| abstract_inverted_index.contrast, | 150 |
| abstract_inverted_index.evaluated | 65 |
| abstract_inverted_index.exhibited | 81 |
| abstract_inverted_index.flavonoid | 27 |
| abstract_inverted_index.formation | 126 |
| abstract_inverted_index.including | 70 |
| abstract_inverted_index.involving | 188 |
| abstract_inverted_index.potential | 173 |
| abstract_inverted_index.response. | 168 |
| abstract_inverted_index.sensitive | 98 |
| abstract_inverted_index.<italic>P. | 109, 123 |
| abstract_inverted_index.<italic>S. | 161, 189 |
| abstract_inverted_index.antibiotic | 144 |
| abstract_inverted_index.especially | 38 |
| abstract_inverted_index.inhibitory | 83 |
| abstract_inverted_index.pathogens, | 6 |
| abstract_inverted_index.pathogens. | 205 |
| abstract_inverted_index.planktonic | 112 |
| abstract_inverted_index.prenylated | 26 |
| abstract_inverted_index.properties | 63 |
| abstract_inverted_index.techniques | 53 |
| abstract_inverted_index.tobramycin | 129 |
| abstract_inverted_index.underscore | 171 |
| abstract_inverted_index.development | 198 |
| abstract_inverted_index.disruptive, | 156 |
| abstract_inverted_index.infections, | 185 |
| abstract_inverted_index.inhibitory, | 155 |
| abstract_inverted_index.penetration | 130, 145 |
| abstract_inverted_index.resistance, | 2 |
| abstract_inverted_index.therapeutic | 21 |
| abstract_inverted_index.anti-biofilm | 62 |
| abstract_inverted_index.bactericidal | 85 |
| abstract_inverted_index.demonstrated | 153 |
| abstract_inverted_index.highlighting | 193 |
| abstract_inverted_index.particularly | 3, 186 |
| abstract_inverted_index.structurally | 55 |
| abstract_inverted_index.Antimicrobial | 1 |
| abstract_inverted_index.Gram-negative | 204 |
| abstract_inverted_index.Gram-positive | 40, 90, 182 |
| abstract_inverted_index.antibacterial | 60 |
| abstract_inverted_index.antimicrobial | 36 |
| abstract_inverted_index.concentration | 136 |
| abstract_inverted_index.significantly | 142 |
| abstract_inverted_index.dose-dependent | 167 |
| abstract_inverted_index.<italic>Sophora | 30 |
| abstract_inverted_index.biofilm-forming | 5 |
| abstract_inverted_index.chromatographic | 52 |
| abstract_inverted_index.<italic>Listeria | 93 |
| abstract_inverted_index.Sophoraflavanone | 23, 45, 140, 175 |
| abstract_inverted_index.biofilm-associated | 184 |
| abstract_inverted_index.<italic>Pseudomonas | 71 |
| abstract_inverted_index.aeruginosa</italic> | 72, 110, 124 |
| abstract_inverted_index.biofilm-penetrating | 158 |
| abstract_inverted_index.pachycarpa</italic> | 31 |
| abstract_inverted_index.epidermidis</italic> | 76, 162, 190 |
| abstract_inverted_index.<italic>Staphylococcus | 75 |
| abstract_inverted_index.monocytogenes</italic> | 94 |
| abstract_inverted_index.<title>Abstract</title> | 0 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 6 |
| citation_normalized_percentile |