Antibodies targeting merozoites induce natural killer cell degranulation and interferon gamma secretion and are associated with immunity against malaria Article Swipe
Dennis Odera
,
James Tuju
,
Kennedy Mwai
,
Irene N. Nkumama
,
Kristin Fürle
,
Timothy Chege
,
Rinter Kimathi
,
Stefan Diel
,
Fauzia K. Musasia
,
Micha Rosenkranz
,
Patricia Njuguna
,
Mainga Hamaluba
,
Melissa C. Kapulu
,
Roland Frank
,
Faith Osier
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.12.14.21267763
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.12.14.21267763
Natural killer cells are potent immune effectors that can be activated via antibody mediated Fc receptor engagement. Using multiparameter flow cytometry, we found that natural killer (NK) cells degranulate and release IFNγ upon stimulation with antibody-opsonized Plasmodium falciparum merozoites. Antibody-dependent NK activity (Ab-NK) was largely strain-transcending and enhanced the inhibition of invasion into erythrocytes. Ab-NK was associated with the successful control of parasitemia following experimental malaria challenge in African adults. In an independent cohort study in children, Ab-NK increased with age, was boosted by concurrent falciparum infections and associated with a lower risk of clinical episodes of malaria. Nine of 14 vaccine candidates tested induced Ab-NK including some less well-studied antigens - P41, P113, MSP11, RHOPH3, and Pf _11363200. These data highlight an important role for ab-NK in immunity against malaria and provide a new mechanism for the evaluation of vaccine candidates One Sentence Summary Antibody-dependent natural killer activation is induced by merozoites and associated with immunity against malaria
Related Topics
Concepts
Antibody
Parasitemia
Immunology
Biology
Malaria
Degranulation
Immunity
Lymphokine-activated killer cell
Immune system
Plasmodium falciparum
Malaria vaccine
Virology
Interleukin 21
Receptor
T cell
Biochemistry
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2021.12.14.21267763
- https://www.medrxiv.org/content/medrxiv/early/2021/12/16/2021.12.14.21267763.full.pdf
- OA Status
- green
- Cited By
- 2
- References
- 57
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4200055056
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4200055056Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2021.12.14.21267763Digital Object Identifier
- Title
-
Antibodies targeting merozoites induce natural killer cell degranulation and interferon gamma secretion and are associated with immunity against malariaWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
-
2021-12-16Full publication date if available
- Authors
-
Dennis Odera, James Tuju, Kennedy Mwai, Irene N. Nkumama, Kristin Fürle, Timothy Chege, Rinter Kimathi, Stefan Diel, Fauzia K. Musasia, Micha Rosenkranz, Patricia Njuguna, Mainga Hamaluba, Melissa C. Kapulu, Roland Frank, Faith OsierList of authors in order
- Landing page
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https://doi.org/10.1101/2021.12.14.21267763Publisher landing page
- PDF URL
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https://www.medrxiv.org/content/medrxiv/early/2021/12/16/2021.12.14.21267763.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.medrxiv.org/content/medrxiv/early/2021/12/16/2021.12.14.21267763.full.pdfDirect OA link when available
- Concepts
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Antibody, Parasitemia, Immunology, Biology, Malaria, Degranulation, Immunity, Lymphokine-activated killer cell, Immune system, Plasmodium falciparum, Malaria vaccine, Virology, Interleukin 21, Receptor, T cell, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
- Citations by year (recent)
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2022: 2Per-year citation counts (last 5 years)
- References (count)
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57Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.Summary | 145 |
| abstract_inverted_index.adults. | 70 |
| abstract_inverted_index.against | 130, 158 |
| abstract_inverted_index.boosted | 83 |
| abstract_inverted_index.control | 61 |
| abstract_inverted_index.induced | 105, 151 |
| abstract_inverted_index.largely | 45 |
| abstract_inverted_index.malaria | 66, 131, 159 |
| abstract_inverted_index.natural | 25, 147 |
| abstract_inverted_index.provide | 133 |
| abstract_inverted_index.release | 31 |
| abstract_inverted_index.vaccine | 102, 141 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Sentence | 144 |
| abstract_inverted_index.activity | 42 |
| abstract_inverted_index.antibody | 13 |
| abstract_inverted_index.antigens | 111 |
| abstract_inverted_index.clinical | 95 |
| abstract_inverted_index.enhanced | 48 |
| abstract_inverted_index.episodes | 96 |
| abstract_inverted_index.immunity | 129, 157 |
| abstract_inverted_index.invasion | 52 |
| abstract_inverted_index.malaria. | 98 |
| abstract_inverted_index.mediated | 14 |
| abstract_inverted_index.receptor | 16 |
| abstract_inverted_index.activated | 11 |
| abstract_inverted_index.challenge | 67 |
| abstract_inverted_index.children, | 77 |
| abstract_inverted_index.effectors | 7 |
| abstract_inverted_index.following | 64 |
| abstract_inverted_index.highlight | 122 |
| abstract_inverted_index.important | 124 |
| abstract_inverted_index.including | 107 |
| abstract_inverted_index.increased | 79 |
| abstract_inverted_index.mechanism | 136 |
| abstract_inverted_index.Plasmodium | 37 |
| abstract_inverted_index._11363200. | 119 |
| abstract_inverted_index.activation | 149 |
| abstract_inverted_index.associated | 57, 89, 155 |
| abstract_inverted_index.candidates | 103, 142 |
| abstract_inverted_index.concurrent | 85 |
| abstract_inverted_index.cytometry, | 21 |
| abstract_inverted_index.evaluation | 139 |
| abstract_inverted_index.falciparum | 38, 86 |
| abstract_inverted_index.infections | 87 |
| abstract_inverted_index.inhibition | 50 |
| abstract_inverted_index.merozoites | 153 |
| abstract_inverted_index.successful | 60 |
| abstract_inverted_index.degranulate | 29 |
| abstract_inverted_index.engagement. | 17 |
| abstract_inverted_index.independent | 73 |
| abstract_inverted_index.merozoites. | 39 |
| abstract_inverted_index.parasitemia | 63 |
| abstract_inverted_index.stimulation | 34 |
| abstract_inverted_index.experimental | 65 |
| abstract_inverted_index.well-studied | 110 |
| abstract_inverted_index.erythrocytes. | 54 |
| abstract_inverted_index.multiparameter | 19 |
| abstract_inverted_index.Antibody-dependent | 40, 146 |
| abstract_inverted_index.antibody-opsonized | 36 |
| abstract_inverted_index.strain-transcending | 46 |
| cited_by_percentile_year.max | 96 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5032797803 |
| countries_distinct_count | 4 |
| institutions_distinct_count | 15 |
| corresponding_institution_ids | https://openalex.org/I223822909, https://openalex.org/I2802164966, https://openalex.org/I2841861, https://openalex.org/I47508984 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8700000047683716 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.49100604 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |