Antibody-functionalized MXene-based electrochemical biosensor for point-of-care detection of vitamin D deficiency Article Swipe
Sharat Chandra Barman
,
Yuming Jin
,
Jehad K. El‐Demellawi
,
Simil Thomas
,
Nimer Wehbe
,
Yongjiu Lei
,
Mrinal K. Hota
,
Xiangming Xu
,
Erol Hasan
,
Omar F. Mohammed
,
Osman M. Bakr
,
Dana Alsulaiman
,
Husam N. Alshareef
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s43246-025-00756-9
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s43246-025-00756-9
Clinical studies routinely show that individuals suffer from vitamin D deficiency, which can result in health complications that include cardiovascular disease, autoimmune disorders, neurodegenerative diseases, and different skeletal deformities. Given its integral role in homeostasis and connection to many pathologies, early diagnosis of vitamin D deficiency is crucial. However, monitoring vitamin D levels is challenging, particularly in remote regions, due to the cost, time, and complexity of existing methods. Here, we develop an electrochemical biosensor for vitamin D based on antibody-functionalized MXenes, offering clinically relevant sensitivity, specificity, and amenability for point-of-care testing. Ti3C2Tx MXene nanosheets are amine-functionalized by electrostatically-driven modification with polyethylenimine, whose functionalities are then used for covalent conjugation of anti-vitamin D antibodies via glutaraldehyde chemistry. This platform achieves a detection limit of 1 pg mL−1 with a dynamic range (0.1–500 ng mL−1) that covers clinically relevant deficiency, insufficiency, sufficiency, and toxicity.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s43246-025-00756-9
- OA Status
- gold
- Cited By
- 16
- References
- 60
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4407633467
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4407633467Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s43246-025-00756-9Digital Object Identifier
- Title
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Antibody-functionalized MXene-based electrochemical biosensor for point-of-care detection of vitamin D deficiencyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-02-17Full publication date if available
- Authors
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Sharat Chandra Barman, Yuming Jin, Jehad K. El‐Demellawi, Simil Thomas, Nimer Wehbe, Yongjiu Lei, Mrinal K. Hota, Xiangming Xu, Erol Hasan, Omar F. Mohammed, Osman M. Bakr, Dana Alsulaiman, Husam N. AlshareefList of authors in order
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https://doi.org/10.1038/s43246-025-00756-9Publisher landing page
- Open access
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
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https://doi.org/10.1038/s43246-025-00756-9Direct OA link when available
- Concepts
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Biosensor, Point of care, Antibody, Electrochemistry, Medicine, Point-of-care testing, Materials science, Chemistry, Nanotechnology, Immunology, Nursing, Electrode, Physical chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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16Total citation count in OpenAlex
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2025: 16Per-year citation counts (last 5 years)
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60Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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