Antidepressant Effect of Crocin in Mice with Chronic Mild Stress Article Swipe
Walaa F. Alsanie
,
Abdulhakeem S. Alamri
,
Osama Abdulaziz
,
Magdi M. Salih
,
Abdulwahab Alamri
,
Syed Mohammed Basheeruddin Asdaq
,
Mohammed H. Alhomrani
,
Majid Alhomrani
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/molecules27175462
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/molecules27175462
This study aimed to investigate the antidepressant property of crocin (Crocetin digentiobiose ester) using a chronic mild stress (CMS)-induced depression model in experimental mice. The tail suspension test (TST) and the sucrose preference test were used to evaluate the antidepressant effect on albino mice of either sex after three weeks of CMS. The period of immobility in the TST and percentage preference for sucrose solution were recorded. By monitoring brain malondialdehyde (MDA) level, catalase (CAT) activity, and reduced glutathione (GSH) level, the antioxidant potential was assessed. Three dosages of crocin (4.84, 9.69, and 19.38 mg/kg) were evaluated. When compared to controls, animals that received crocin administration during three periods of CMS had considerably shorter immobility times during the TST. Crocin treatment also raised the percentage preference for sucrose solution in a dose-dependent manner, bringing it to parity with the conventional antidepressant, imipramine. Animals that received a high dose of crocin had a much greater spontaneous locomotor activity. Furthermore, a high dose of crocin remarkably lowered plasma corticosterone and nitrite levels brought on by CMS. Additionally, high doses of crocin given during CMS greatly enhanced reduced glutathione levels while considerably reducing the brain’s MDA and catalase activities. In conclusion, high doses of crocin may have an antidepressant effect in an animal model through several mechanisms. However, further studies should be carried out to explore the role of neurotransmitters for their antidepressant property.
Related Topics
Concepts
Crocin
Pharmacology
Behavioural despair test
Chemistry
Antidepressant
Imipramine
Tail suspension test
Glutathione
Malondialdehyde
Antioxidant
Medicine
Biochemistry
Endocrinology
Hippocampus
Enzyme
Pathology
Alternative medicine
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/molecules27175462
- https://www.mdpi.com/1420-3049/27/17/5462/pdf?version=1661433613
- OA Status
- gold
- Cited By
- 13
- References
- 78
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4293207186
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4293207186Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/molecules27175462Digital Object Identifier
- Title
-
Antidepressant Effect of Crocin in Mice with Chronic Mild StressWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-08-25Full publication date if available
- Authors
-
Walaa F. Alsanie, Abdulhakeem S. Alamri, Osama Abdulaziz, Magdi M. Salih, Abdulwahab Alamri, Syed Mohammed Basheeruddin Asdaq, Mohammed H. Alhomrani, Majid AlhomraniList of authors in order
- Landing page
-
https://doi.org/10.3390/molecules27175462Publisher landing page
- PDF URL
-
https://www.mdpi.com/1420-3049/27/17/5462/pdf?version=1661433613Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1420-3049/27/17/5462/pdf?version=1661433613Direct OA link when available
- Concepts
-
Crocin, Pharmacology, Behavioural despair test, Chemistry, Antidepressant, Imipramine, Tail suspension test, Glutathione, Malondialdehyde, Antioxidant, Medicine, Biochemistry, Endocrinology, Hippocampus, Enzyme, Pathology, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
13Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 7, 2023: 2, 2022: 1Per-year citation counts (last 5 years)
- References (count)
-
78Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.reduced | 77, 184 |
| abstract_inverted_index.several | 212 |
| abstract_inverted_index.shorter | 113 |
| abstract_inverted_index.studies | 216 |
| abstract_inverted_index.sucrose | 31, 63, 127 |
| abstract_inverted_index.through | 211 |
| abstract_inverted_index.However, | 214 |
| abstract_inverted_index.bringing | 133 |
| abstract_inverted_index.catalase | 73, 194 |
| abstract_inverted_index.compared | 98 |
| abstract_inverted_index.enhanced | 183 |
| abstract_inverted_index.evaluate | 37 |
| abstract_inverted_index.property | 7 |
| abstract_inverted_index.received | 103, 144 |
| abstract_inverted_index.reducing | 189 |
| abstract_inverted_index.solution | 64, 128 |
| abstract_inverted_index.(Crocetin | 10 |
| abstract_inverted_index.activity, | 75 |
| abstract_inverted_index.activity. | 156 |
| abstract_inverted_index.assessed. | 85 |
| abstract_inverted_index.brain’s | 191 |
| abstract_inverted_index.controls, | 100 |
| abstract_inverted_index.locomotor | 155 |
| abstract_inverted_index.potential | 83 |
| abstract_inverted_index.property. | 230 |
| abstract_inverted_index.recorded. | 66 |
| abstract_inverted_index.treatment | 120 |
| abstract_inverted_index.depression | 19 |
| abstract_inverted_index.evaluated. | 96 |
| abstract_inverted_index.immobility | 55, 114 |
| abstract_inverted_index.monitoring | 68 |
| abstract_inverted_index.percentage | 60, 124 |
| abstract_inverted_index.preference | 32, 61, 125 |
| abstract_inverted_index.remarkably | 163 |
| abstract_inverted_index.suspension | 26 |
| abstract_inverted_index.activities. | 195 |
| abstract_inverted_index.antioxidant | 82 |
| abstract_inverted_index.conclusion, | 197 |
| abstract_inverted_index.glutathione | 78, 185 |
| abstract_inverted_index.imipramine. | 141 |
| abstract_inverted_index.investigate | 4 |
| abstract_inverted_index.mechanisms. | 213 |
| abstract_inverted_index.spontaneous | 154 |
| abstract_inverted_index.Furthermore, | 157 |
| abstract_inverted_index.considerably | 112, 188 |
| abstract_inverted_index.conventional | 139 |
| abstract_inverted_index.experimental | 22 |
| abstract_inverted_index.(CMS)-induced | 18 |
| abstract_inverted_index.Additionally, | 174 |
| abstract_inverted_index.digentiobiose | 11 |
| abstract_inverted_index.administration | 105 |
| abstract_inverted_index.antidepressant | 6, 39, 205, 229 |
| abstract_inverted_index.corticosterone | 166 |
| abstract_inverted_index.dose-dependent | 131 |
| abstract_inverted_index.antidepressant, | 140 |
| abstract_inverted_index.malondialdehyde | 70 |
| abstract_inverted_index.neurotransmitters | 226 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5039651839, https://openalex.org/A5028700323 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 8 |
| corresponding_institution_ids | https://openalex.org/I179331831, https://openalex.org/I4391767729 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7699999809265137 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.83988296 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |